Fagan Lab at the University of Sheffield
@RobFagan
Followers
2K
Following
4K
Media
8
Statuses
114
We are the Clostridial Cell Biology Group at the University of Sheffield @sheffielduni @MM_Sheffield Clostridial cell biology & phage structure and function.
Sheffield
Joined December 2010
🚨 Fully funded PhD studentships 🚨 We have 3 fully funded PhD studentships available for Oct 26 start. Funded by the MRC DiMeN programme & the BBSRC Yorkshire Biosciences DTP. Details below as they are advertised. Contact me here or via email for more details or to discuss
1
1
0
Project 3: Predicting pathogen evolution: using experimental evolution to understand the impact of phage therapy on Clostridioides difficile. https://t.co/inUqeiMp9W
0
0
0
Project 2: Doubling down: determining the dual function of VanT in C. difficile antibiotic resistance. https://t.co/JotkIpjT6X
1
0
0
Project 1: Life and death in the age of vancomycin: visualising how Clostridioides difficile survives antibiotic treatment at the single cell level. https://t.co/KmUEwZH4kc
1
0
0
You can find out more about our group and our research here: https://t.co/U6cY9UZVk1
sites.google.com
We are the Clostridial Cell Biology Group at the University of Sheffield. We study all aspects of cell biology, including the architecture and biogenesis of surface structures on both vegetative...
1
0
0
🚨 Fully funded PhD studentships 🚨 We have 3 fully funded PhD studentships available for Oct 26 start. Funded by the MRC DiMeN programme & the BBSRC Yorkshire Biosciences DTP. Details below as they are advertised. Contact me here or via email for more details or to discuss
1
1
0
More info on the MSCA schemes here: https://t.co/dncYfULb3I and you can see a few of our current projects here: https://t.co/6IrZGzScdy
sites.google.com
We are interested in all aspects of Clostridial cell biology. Current projects focus on Antimicrobial Resistance in C. difficile, the structural transitions in spore germination, and the structure of...
0
0
1
The Marie Skłodowska-Curie Actions Fellowships support applicants up to 8 years post-PhD from anywhere in the world who want to spend 1-2 years working in Europe (incl. UK!). These can be a fantastic stepping stone to longer term fellowships and establishing independence
1
0
1
The 2025 round of the MSCA Postdoc Fellowships launches soon, with a deadline of September 10th. If you're interested in Clostridial cell biology and looking for a host lab for your fellowship please get in touch to discuss possible projects
1
0
2
There is still a huge amount of work to do but this is a fascinating first look at an S-layer penetrating phage!
0
0
1
Interestingly the tail contracts less than in other characterised phages (& related contractile structures). This seems to be a feature of phage infecting bacteria that have an S-layer - given that these are likely the majority of bacteria, this is probably really common
1
0
0
Our structures reveal the conformational changes that lead to the contraction of the phage tail Unfortunately the videos won't upload here - but go look at them in the paper!
1
0
0
phiCD508 is a 23 MDa contractile phage that specifically recognises the major C. difficile S-layer protein SlpA and that can penetrate the cell envelope via a seemingly non-enzymatic mechanism
1
0
0
It's been a really fun project, led by Jason Wilson in collaboration with Per Bullough and Louis-Charles Fortier at the Université de Sherbrooke - now published in @LSAjournal
https://t.co/FPVARdAvX8
life-science-alliance.org
The molecular details of phage tail contraction and bacterial cell envelope penetration remain poorly understood and are completely unknown for phages infecting bacteria enveloped by proteinaceous...
1
0
0
New paper alert 🚨 We've solved the complete structure of a C. difficile-infecting phage using cryo-EM, in both extended and contracted conformations - published today in Life Science Alliance
1
16
70
The 2nd round of our Yorkshire Biosciences PhD programme is now open for applications - deadline March 14th. Both of our C. diff phage projects are also available in this round - details in the thread below. More info and expressions of interest here: https://t.co/6SiwWk7YOP
0
8
10
No2...Predicting pathogen evolution: using experimental evolution to understand the impact of phage therapy on Clostridioides difficile with @RobFagan
https://t.co/Bo8IcVlhbK
#microbialevolution #pathogenevolution #PhDposition
findaphd.com
PhD Project - Predicting pathogen evolution: using experimental evolution to understand the impact of phage therapy on Clostridioides difficile at University of Sheffield, listed on FindAPhD.com
1
1
2
PhDs avaliable in the lab! No1....what are rhizobia up to OUTSIDE the symbiosis? https://t.co/wd9YfptMag with Prof Tim Daniell. Come along to our project info session Tues 10th at 2pm. register here https://t.co/kWLsCx2Ztl
#microbialevolution #symbiosis #PhDposition
1
3
5
Project 2: Led by Per Bullough and in collaboration with @Sheffield_AFM we will study the structural basis of #phage infection of #Cdiff cells at unprecedented resolution. #cryoEM #AFM
https://t.co/Dkutq9Immp
findaphd.com
PhD Project - Mechanism of phage infection in the C. difficile pathogen- towards effective phage therapy at University of Sheffield, listed on FindAPhD.com
0
1
4
Project 1: Led by @ellieevolves, we will study the evolutionary interplay between #Cdiff and #phage and impact of sporulation on this relationship. https://t.co/UkjV2MRS1K
findaphd.com
PhD Project - Predicting pathogen evolution: using experimental evolution to understand the impact of phage therapy on Clostridioides difficile at University of Sheffield, listed on FindAPhD.com
1
0
3