Fagan Lab at the University of Sheffield
@RobFagan
Followers
2K
Following
4K
Media
5
Statuses
109
We are the Clostridial Cell Biology Group at the University of Sheffield @sheffielduni @MM_Sheffield Clostridial cell biology & phage structure and function.
Sheffield
Joined December 2010
More info on the MSCA schemes here:.and you can see a few of our current projects here:.
sites.google.com
We are interested in all aspects of Clostridial cell biology. Current projects focus on Antimicrobial Resistance in C. difficile, the structural transitions in spore germination, and the structure of...
0
0
1
The Marie Skłodowska-Curie Actions Fellowships support applicants up to 8 years post-PhD from anywhere in the world who want to spend 1-2 years working in Europe (incl. UK!). These can be a fantastic stepping stone to longer term fellowships and establishing independence.
1
0
1
The 2025 round of the MSCA Postdoc Fellowships launches soon, with a deadline of September 10th. If you're interested in Clostridial cell biology and looking for a host lab for your fellowship please get in touch to discuss possible projects
1
0
2
There is still a huge amount of work to do but this is a fascinating first look at an S-layer penetrating phage!.
0
0
1
Interestingly the tail contracts less than in other characterised phages (& related contractile structures). This seems to be a feature of phage infecting bacteria that have an S-layer - given that these are likely the majority of bacteria, this is probably really common
1
0
0
Our structures reveal the conformational changes that lead to the contraction of the phage tail. Unfortunately the videos won't upload here - but go look at them in the paper!.
1
0
0
phiCD508 is a 23 MDa contractile phage that specifically recognises the major C. difficile S-layer protein SlpA and that can penetrate the cell envelope via a seemingly non-enzymatic mechanism.
1
0
0
It's been a really fun project, led by Jason Wilson in collaboration with Per Bullough and Louis-Charles Fortier at the Université de Sherbrooke - now published in @LSAjournal.
life-science-alliance.org
The molecular details of phage tail contraction and bacterial cell envelope penetration remain poorly understood and are completely unknown for phages infecting bacteria enveloped by proteinaceous...
1
0
0
New paper alert 🚨 We've solved the complete structure of a C. difficile-infecting phage using cryo-EM, in both extended and contracted conformations - published today in Life Science Alliance
1
16
70
The 2nd round of our Yorkshire Biosciences PhD programme is now open for applications - deadline March 14th. Both of our C. diff phage projects are also available in this round - details in the thread below. More info and expressions of interest here:.
0
8
10
RT @ellieevolves: No2. Predicting pathogen evolution: using experimental evolution to understand the impact of phage therapy on Clostridio….
findaphd.com
PhD Project - Predicting pathogen evolution: using experimental evolution to understand the impact of phage therapy on Clostridioides difficile at University of Sheffield, listed on FindAPhD.com
0
1
0
RT @ellieevolves: PhDs avaliable in the lab! No1. what are rhizobia up to OUTSIDE the symbiosis? with Prof Tim Da….
0
3
0
Project 2: Led by Per Bullough and in collaboration with @Sheffield_AFM we will study the structural basis of #phage infection of #Cdiff cells at unprecedented resolution. #cryoEM #AFM.
findaphd.com
PhD Project - Mechanism of phage infection in the C. difficile pathogen- towards effective phage therapy at University of Sheffield, listed on FindAPhD.com
0
1
3
Project 1: Led by @ellieevolves, we will study the evolutionary interplay between #Cdiff and #phage and impact of sporulation on this relationship.
findaphd.com
PhD Project - Predicting pathogen evolution: using experimental evolution to understand the impact of phage therapy on Clostridioides difficile at University of Sheffield, listed on FindAPhD.com
1
0
2
We have 2 fully funded PhD studentships available through the new Yorkshire Biosciences DTP (starting Oct 25) - please share! Both projects are focussed on #phage that infect #Cdifficile
2
42
122