RO TRIAD
@RoTriad
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*Unofficial* Stylized Dr. Ro triads from 2pm lectures | tweets ≠ medical advice | #Pathology simplified in 1-2-3 | #AtTheScope #pathologists #pathology
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Joined January 2015
Helpful features in yolk sac tumor: eosinophilia hyaline globules, basement membrane-like material, Schiller-Duval bodies.
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Nots of Spermatocytic Tumor: not assoc with ITGCN, not assoc with undescended testis, not seen outside testis.
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Spermatocytic Tumor: Small lymphocyte-like cells, large cells with, soccer ball-like chromatin, intermediate cells.
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Beware of testis germ cell tumor cells hiding in prominent granulomatous inflammation. OCT3/4 can help highlight them.
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Choriocarcinoma: two cell population (mononuclear/multinucleated giant cell), hemorrhage, spatial arrangement (vague villous configuration).
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Intratubular germ cell neoplasia: clear cytoplasm, nuclear enlargement, prominent nucleolus. Use OCT3/4 to diff btw ITGCN (+) vs other (-).
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Reporting lymph node metastasis: number of positive nodes, extranodal extension present/absent, size of largest tumor deposit.
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Extension of urothelial cancer to prostate: within prostate gland only = T2, with stromal invasion through prostate gland = T4.
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Remember the 2 types of noninvasive carcinoma in bladder: Ta = noninvasive papillary carcinoma, Tis = carcinoma in situ; give low/high grade.
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Inverted urothelial papillary lesions: inverted papilloma/PUNLMP, inverted papillary urothelial carcinoma, carcinoma associated w/ papilloma.
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Urothelial papillary neoplasm: 2) low vs high grade carcinoma; use worst component, high with pleomorphism, inc nuclear size, >10 mit/10 hpf.
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