The Prince Lab
@PrinceLab_UofC
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Prince Lab @UChicago. Vertebrate #development with a focus on zebrafish: patterning and migration of neurons, neural crest and placodes + education and outreach
Chicago, IL
Joined December 2020
Had such a great time working with the best undergrad this summer! So proud of Rachel’s impressive new HCR skills (below)! Sad she’s going back to class/can’t be in lab full time this fall, but am very lucky she’s going to continue working with me on our pronephric adventures 🐟
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Adult zebrafish cranial nerves, courtesy of Prince lab wondergrad Theresa Christiansen. #biologyisbeautiful
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Congratulations Noel and Marco! Onward and upward :)
Phenomenal honors thesis on lateral lines and neural crest by @PrinceLab_UofC wondergrad Noel and amazing work on shark lateral lines by Coates lab wondergrad Marco! An honor to have worked with these two. Go #teamlateralline
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And thank you @MadS100tist and @LabPiotrowski for getting us started with these gorgeous fish in the first place!
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Fantastic talks by Prince lab wondergrads Noel McGrory and Theresa Christiansen on the development and innervation of #zebrafish lateral lines!
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Congratulations to Prince Lab postdoc @parahsaramore on her latest publication looking at how Vangl works in the pulmonary mesenchyme to form lung sacculi! Another great reminder that development is beautiful :)
So pleased to announce that the first chunk of my graduate work is out now in @Dev_Cell 🫁🐭🔬 here we investigated the role of the planar cell polarity complex in lung sacculation, identifying a PCP-independent role for Vangl in the pulmonary mesenchyme https://t.co/UgEFcqxLT9
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Neighbour/partner lab (the Coates lab) wondergrad Marco Lopez from #teamlateralline talking about his amazing work on #shark lateral lines and eco morphology at #SICB2024
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Neural crest, placodes, sharks and cephalopods- Prince and Coates labs wrapping up an incredible #sicb2024!
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Next Prince lab wondergrad Noel McGrory talked about his fascinating findings on the relationships between #zebrafish neural crest and cranial placodes at #SICB2024
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Prince lab debuts at #SICB2024 with wondergrad Theresa Christiansen talking about her amazing work on lateral line innervation and development- at her first ever conference presentation!
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New folks, new updates, same old Chicago fall and same old #zebrafish!
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I'm excited to announce that @InSDB_79 will be the official guest society of @SocDevBio at the 2023 SDB meeting. Don't forget abstract submission closes April 10th https://t.co/hdC7MIshi4.
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And it’s a wrap! @UChicago and @MBLScience’s first Mini embryology course, led by our very own @Lab_VPrince and Nipam Patel finished its two week debut today. Here’s to our amazing instructors and all flies, butterflies, zebrafish, squids, chicks and anemones!
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n/n in summary, this work shows that in #zebrafish (like other vertebrates) the head is not like the trunk, and it’s specification and migration are controlled by distinct genes- like cdx4!
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6/n the environment matters, but only sometimes, it seems. Elegant cell transplantation studies showed that Cdx4 activity was not required in the somitic mesoderm for proper crest migration
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4/n some lovely bioinformatics analyses- spearheaded by lab undergrad Clare Booth- followed up on seminal work from @TSS_Lab and @leonard_zon showed that Cdx4 regulates downstream specifier genes!
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5/n: confocal microscopy reminded us that development is beautiful, but also revealed that Cdx4 deficient zebrafish show aberrant trunk crest migration. Specifically, the ‘leader’ cells lose their identities (politics much?):
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