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Plevka Lab

@PlevkaLab

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blsk: plevkalab structural virology โ˜ฃ๏ธ, #cryoEM #cryoET #Lightsheet ๐Ÿ”ฌ at @CEITEC_Brno | Tweets by students.

Brno, Czech Republic
Joined October 2017
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@PlevkaLab
Plevka Lab
7 months
โ„๏ธ Enjoying the first and, hopefully, not the last, snow of this winter โ„๏ธ
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@PlevkaLab
Plevka Lab
8 months
Stay tuned for more insights into viral entry mechanisms! ๐Ÿงซ.If you liked this #tweetorial, please retweet the first tweet. Endosome rupture enables enteroviruses from the family Picornaviridae to infect cells.#CEITECScience.9/9.
@PlevkaLab
Plevka Lab
8 months
โœจ๐—ก๐—˜๐—ช ๐—ฃ๐—”๐—ฃ๐—˜๐—ฅ ๐—”๐—Ÿ๐—˜๐—ฅ๐—งโœจ.We are happy to announce that the paper by Aygul Ishemgulova @IshemgulovaA and members of our group, describing the novel mechanism of cell invasion by enteroviruses is now published in @CommsBio! ๐Ÿฆ .Letโ€™s break it down! .๐Ÿงต .1/9
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@PlevkaLab
Plevka Lab
8 months
๐—ช๐—ต๐˜† ๐—ฑ๐—ผ๐—ฒ๐˜€ ๐˜๐—ต๐—ถ๐˜€ ๐—บ๐—ฎ๐˜๐˜๐—ฒ๐—ฟ?.This study brings us closer to the fundamental understanding of the infection process. 8/9
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@PlevkaLab
Plevka Lab
8 months
๐— ๐—ฒ๐—บ๐—ฏ๐—ฟ๐—ฎ๐—ป๐—ฒ ๐˜„๐—ฎ๐—ฟ๐—ฝ๐—ถ๐—ป๐—ด ๐—ฎ๐—ป๐—ฑ ๐—ฒ๐—ป๐—ฑ๐—ผ๐˜€๐—ผ๐—บ๐—ฒ ๐—ฟ๐˜‚๐—ฝ๐˜๐˜‚๐—ฟ๐—ฒ.Actin filaments observed at membrane protrusions, along with actin polymerisation inhibition results suggest cellular actin can drive endosome rupture. 7/9
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@PlevkaLab
Plevka Lab
8 months
On the contrary, inhibition of endosome acidification didnโ€™t stop genome-containing particles from exiting the endosomes. 6/9
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@PlevkaLab
Plevka Lab
8 months
๐—–๐—ฎ๐—ป ๐—ฐ๐—ฒ๐—น๐—น๐˜‚๐—น๐—ฎ๐—ฟ ๐—บ๐—ฒ๐—ฐ๐—ต๐—ฎ๐—ป๐—ถ๐˜€๐—บ๐˜€ ๐—ฏ๐—ฒ ๐—ถ๐—ป๐˜ƒ๐—ผ๐—น๐˜ƒ๐—ฒ๐—ฑ? ๐Ÿฆ .Inhibition of the actin polymerisation led to genome release within the endosomes, hindering the virus replication. 5/9
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@PlevkaLab
Plevka Lab
8 months
๐—›๐—ผ๐˜„ ๐—ฑ๐—ถ๐—ฑ ๐˜๐—ต๐—ฒ๐˜† ๐—ฑ๐—ผ ๐—ถ๐˜?.Using advanced #cryoET @cemcof to visualise cell entry of rhinovirus 2, echovirus 18, echovirus 30, and enterovirus 71 โ€“ right in action! ๐Ÿ”Ž.4/9
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@PlevkaLab
Plevka Lab
8 months
๐—ž๐—ฒ๐˜† ๐—™๐—ถ๐—ป๐—ฑ๐—ถ๐—ป๐—ด๐˜€.This study reveals that enterovirus-containing #endosomes can deform and rupture, enabling the release of genome-containing particles into the cytoplasm. 3/9
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@PlevkaLab
Plevka Lab
8 months
#Enteroviruses, members of the Picornaviridae family, cause illnesses ranging from the common cold to encephalitis ๐Ÿ˜ท However, the infection process was never observed ๐˜ช๐˜ฏ ๐˜ท๐˜ช๐˜ท๐˜ฐ - until now. 2/9
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@PlevkaLab
Plevka Lab
8 months
โœจ๐—ก๐—˜๐—ช ๐—ฃ๐—”๐—ฃ๐—˜๐—ฅ ๐—”๐—Ÿ๐—˜๐—ฅ๐—งโœจ.We are happy to announce that the paper by Aygul Ishemgulova @IshemgulovaA and members of our group, describing the novel mechanism of cell invasion by enteroviruses is now published in @CommsBio! ๐Ÿฆ .Letโ€™s break it down! .๐Ÿงต .1/9
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@PlevkaLab
Plevka Lab
8 months
Great news from Portugal! #phageTherapy.
@azeredo_joana
Joana Azeredo
8 months
๐Ÿ“ข Historic day for Portugal and phage therapy! ๐Ÿ‡ต๐Ÿ‡น A framework was approved, allowing magistral preparation of personalized phage products. ๐Ÿ™Œ Grateful to Jean-Paul Pirnay, my group @AzeredoLab Portuguese patients, and doctors who signed a petition inspired by the Belgium model.
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@PlevkaLab
Plevka Lab
8 months
RT @paulynamagana: #AlphaFold3 code & weights are now open-source for academics! ๐ŸŽ‰.Looking forward to seeing what new research this unlocksโ€ฆ.
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@PlevkaLab
Plevka Lab
9 months
ฤŒlรกnek s rozhovorem na @Radiozurnal1:.
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@PlevkaLab
Plevka Lab
9 months
๐Ÿ‡จ๐Ÿ‡ฟ Naลกe Dr. Lucie Valentovรก popsala svลฏj vรฝzkum bakteriofรกga JBD30 pro @CRozhlas ๐Ÿ“ข. V rozhovoru se dozvรญte, jakou novou, nรกmi popsanou, strategii pouลพรญvรก fรกg JDB30 na lov svรฉ koล™isti - Pseudomonas aeruginosa ๐Ÿฆ . Odkaz nรญลพe๐Ÿ‘‡
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@PlevkaLab
Plevka Lab
10 months
If you are interested, find the tweetorial and the link to her paper below ๐Ÿ‘‡.
@PlevkaLab
Plevka Lab
11 months
๐Ÿ“ข Publication alert ๐Ÿ“ข.Congratulations to Lucie Valentovรก on her debut paper! ๐Ÿ‘.*Structure and replication of ๐˜—๐˜ด๐˜ฆ๐˜ถ๐˜ฅ๐˜ฐ๐˜ฎ๐˜ฐ๐˜ฏ๐˜ข๐˜ด ๐˜ข๐˜ฆ๐˜ณ๐˜ถ๐˜จ๐˜ช๐˜ฏ๐˜ฐ๐˜ด๐˜ข phage JDB30* recently published in The EMBO Journal! #PhageResearch.@CEITEC_Brno .๐Ÿงต1/12.
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@PlevkaLab
Plevka Lab
10 months
๐ŸŽ‰ Congratulations to freshly minted doctor Lucie Valentovรก #PhDone ๐ŸŽ“. We wish you all the best in your next chapterโ€”your passion and dedication will continue to inspire! ๐ŸŒŸ. #PhD #PhDlife #NextChapter
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@PlevkaLab
Plevka Lab
11 months
12/12.Thanks to our amazing collaborators for making this work possible - kudos especially to @Ceitec_CellimCF and @cemcof !. #CEITECScience #cryoEM #virus #AntibioticResistance.
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@PlevkaLab
Plevka Lab
11 months
11/12.Weโ€™ve walked you through JBD30โ€™s epic journey: from its flexible tail and high-tech docking system to taking over P. aeruginosa cells, assembling DNA-packed heads, and building the ultimate phage army. ๐Ÿš€โœจ
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@PlevkaLab
Plevka Lab
11 months
10/12.Once inside, the phage takes control, turning the cell into a phage factory๐Ÿญ.๐Ÿ› ๏ธ Capsid proteins snap together into procapsids, which then expand - making room for the precious genome๐Ÿ“ฆ.๐Ÿงฉ With their heads full, they team up with the tails, creating the perfect phage squad!
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@PlevkaLab
Plevka Lab
11 months
9/12.The next move in JBD30โ€™s screenplay: The tripod and baseplate spring open, unleashing three copies of the tape-measure protein! ๐Ÿ“.These proteins then unfold into whatโ€™s likely a trans-membrane channelโ€”a perfect escape route for the DNA to make its grand exit.๐Ÿš‡
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