Peter Kobalka
@PeterKobalka
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Pathologist, teacher. Training and interests in neuropathology, cytopathology, thoracic, and general surgical pathology
Joined July 2022
Yes, this is Paraganglioma! Key point is to consider other GATA-3+ entities
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70 F periaortic mass, hx of breast cancer. GATA-3 is shown. Do we have enough to make the diagnosis? #pathx #pathtwitter #cytology #cytopath #cytopathology #pathology
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What is this? Glioma in a CSF! This can be challenging to recognize, as they look nothing like their appearance in surgical specimens! #cytology #cytopath #cytopathology #neuropath #neuropathology #pathx #pathtwitter
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Oh cool! Placenta strongly expresses PD-L1! (Makes sense; you don’t want Mom to attack it…) #immunohistochemistry #pathology #pathtwitter #pathx #ihc
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It's an open secret that #Scientific #publishing is a joke! 😢 If you ever need a funny explanation for a friend who is not familiar with the publish or perish game, here it is - by the brilliant "Dr Glaucomflecken"
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Significance of Medical history- Station 7 lymph node FNA of a 73 years old, large single cells with plasmacytoid and oncocytic features, TTF-1, NapsinA, SOX10 negative, and AR positive DX: metastatic salivary duct carcinoma #CytoPro @AmerSwid @JHUPath @IACytology @IAPCentral
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Mass of spine 32M. Malignant Melanotic Nerve Sheath Tumor (MMNST). Heavily pigmented tumor. Note the frequent psammoma bodies here, a clue to the correct diagnosis. Syndrome/molecular? Other features of this syndrome? #pathx #pathtwitter #neuropath #neuropathology #cnspathology
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What pathologies can be seen in these two photos? In what clinical scenario are these changes typically observed? #neuropath 🧠🔬
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Two, glial markers will be NEGATIVE if all you have is the PNET or sarcoma component of a glioma/gliosarcoma!
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3rd ventricle mass. glial markers negative. SYN+ as is TTF-1 (shown). Molecular signature is GBM. Two important points: TTF-1 is sometimes positive in the PNET component of a glioma! #pathx #pathtwitter #pathology #cnspath #neuropath #neuropathology
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🧠 Medulloblastoma with muscular differentiation (medullomyoblastoma) — practical review 🧾 Definition Medulloblastoma with muscular differentiation (historically “medullomyoblastoma”) is a histologically defined medulloblastoma that shows frank or focal myogenic
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Tylenol causes autism? Maybe we should have Andrew Wakefield weigh in… #Autism #vaccineswork
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CAM5.2 and SMARCA4 shown below. Now, what’s do you think?
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Other considerations included a met SCC (not likely, given histology) NUT Carcinoma and other poorly differentiated entities.
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60s male Hx tonsilar SCC, s/p RT. Now with large ant mediastinal mass. Stains? What’s your diagnosis? Poll below #thoracicpath #pathology #pathtwitter #pathx
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CSF with tumor cells from lobular breast carcinoma. Clues to look for (not all seen in this image): • Single cells & loose clusters • Indian file–like linear arrangement • Cytoplasmic blebs • Semilunar nuclear contour #PathTwitter #MedTwitter #CytoPath #PathResidents
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