Paul Talbert
@PaulTalbert10
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Chromatin geneticist HHMI at Fred Hutchinson Cancer Center
Joined March 2019
Our recent review on genome packaging in giant viruses:.
pubmed.ncbi.nlm.nih.gov
Giant viruses (Nucleocytoviricota) have a largely conserved lifecycle, yet how they cram their large genomes into viral capsids is mostly unknown. The major capsid protein and the packaging ATPase...
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Human satellite centromere expansions and contractions can be measured in ~20 cell generations and depend on RAD52 and PIF1, suggesting break-induced replication.
biorxiv.org
Human centromeres are located within α-satellite arrays and evolve rapidly, which can lead to individual variation in array lengths. Proposed mechanisms for such alterations in lengths are unequal...
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RT @dinokaryon: Excited to share our manuscript about how we studied the function and evolution of giant viral histones to understand the o….
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For anyone who follows me or otherwise happens to read my tweets, it appears that my account was hacked in April. I apologize for the resultant spam, and have changed my password. I am not on here often and was not aware until now.
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Genuinely curious: do the Texas republicans have a rationale for why voting after midnight is okay if the rules say they can't? #UniswapScam.
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Just lost a bunch of USDC an hour ago cause there was an exploit on @Uniswap from when I bought magic earlier today. #UniswapExploit #UniswapHack.
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🚨#UniswapHack #UniswapExploit🚨 If you have interacted with UniSwap recently, please revoke any token approvals.
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My review of the centromere drive model 20 years after it was proposed is out in Current Opinions in Genetics and Development.
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Check out our investigation of Marseillevirus chromatin in Molecular Cell.
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Metagenomic projects have uncovered a wealth of viral histones. What do they do?.
epigeneticsandchromatin.biomedcentral.com
The common histones H2A, H2B, H3, and H4 are the characteristic components of eukaryotic nucleosomes, which function to wrap DNA and compact the genome as well as to regulate access to DNA for...
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Interesting story of episodic duplication, loss and replacement a fundamental enzyme across all three domains of life.
My paper with University of Iowa UG research assistant Oliver Vickman just came out at PLoS ONE! #NADK #LUCA #LECA #metabolism #Nematoda
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