OK, here's today's video. Guided tour of diffusion MRI + tractometry in lots of brain diseases - a bit scary in front of an audience of diffusion MRI experts who know tons more about this than I do ! .(start at 15 min to skip the ENIGMA intro)

[1] Explainable AI Methods for Neuroimaging: Systematic Failures of Common Tools, the Need for Domain-Specific Validation, and a Proposal for Safe Application Nys Tjade Siegel 1, 2 , James H. Cole 3, 4, 5 , Mohamad Habes 6 , Stefan Haufe 7, 8, 9, 10 ,

HOW DO YOU VALIDATE explainable AI - an AI method giving you a "heat map" of features it used to make a decision?.🔥 Cool new paper [1] says many famous methods (Grad-CAM, LRP) behave oddly if you apply them to brain MRI - they sometimes highlight regions that do not really make

[1] Predicting Regional Cerebral Blood Flow Using Voxel-Wise Resting-State Functional MRI.Hongjie Ke †, Bhim M. Adhikari † , Yezhi Pan , David B. Keator, Daniel Amen, Si Gao , Yizhou Ma, Paul M. Thompson, Neda Jahanshad, Jessica A. Turner, Theo G. M. van.

🔥CAN YOU MAP BLOOD FLOW in the brain from resting state fMRI? .🔥Ingenious new method [1] learns from jointly collected ASL (arterial spin labeling), SPECT, and rsFMRI to infer blood flow from fMRI.💡Cool as you can now estimate perfusion from 10000s of scans, of people who

New way of raising money for the lab :)

My daughter made the mistake of asking me what happens in Vergil’s Aeneid and after 20 minutes we only made it as far as Book 6 … :)

[1] recent paper [2] me attempting to explain it

🔥ATAXIA includes rare, inherited neurodegenerative diseases characterised by progressive deterioration in motor coordination + cognitive function. 🔥Ian Harding has been leading global efforts to pool data + expertise on these disorders + categorize these ataxias by age of

Sunset in Redondo Beach, strangely high humidity

[1] [2] Genetic risk in Parkinson's disease and epilepsy:

🔥How does GENETIC RISK FOR DEPRESSION affect your brain?.🔥Extraordinary paper, out today [1], examines genetic risk for depression and brain MRI in 50,975 participants pooled from 11 studies within the ENIGMA Major Depressive Disorder Working Group.🔥People with higher genetic

OK done with grant writing for the day. I may just retire and play the piano in a bar .

BBC once interviewed me at 3 AM*.🤯Probably could’ve used less caffeine.*well they are on UK time

RT @PTenigma: @JasonSynaptic So sorry to hear that Jason, it's completely insane. We also have a 3rd percentile R21, 12th percentile R01, a….

RT @adeelrazi: Have a look at our new preprint where Aswin proposes a (active inference based) generative model informed by the DishBrain e….

Interactive: [1] "A Scalable Toolkit for Modeling 3D Surface-based Brain Geometry" @yanghee_im Yanghee Im, Leila Nabulsi, Melody J.Y. Kang, Sophia I. Thomopoulos, Ana M. Diaz Zuluaga, Anders M. Dale, Andriana Karuk, Annabella Di.

🔥BEAUTIFUL IN-DEPTH analysis of the BIPOLAR BRAIN [1], led by @Yanghee_Im in Chris Ching's lab, + bipolar disorder experts from 64 worldwide sites .🧠Surface-based toolkit -> Deep mapping of subcortical brain structure (N=3,373 people, 14 sites), w. interactive visualizations.🔥

OK heading home to LA

“THE whole sky had been overcast with rain-clouds from early morning; it was a still day, not hot, but heavy, as it is in grey dull weather when the clouds have been hanging over the country for a long while, when one expects rain and it does not come.”

Made it home to Yorkshire for my mother’s 88th birthday !