Peritoneal Surface Oncology Group International
@PSOGI_EC
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Official twitter account of the Peritoneal Surface Oncology Group International (PSOGI) Views expressed are those of the SoMe head of PSOGI @writeslkpushkin
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Joined August 2021
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HIPEC After iCRS Prospective study from🇰🇷
-All 👩🦰<1cm residual disease
-75 Cisplatin & 34 Paclitaxel HIPEC
-similar morbidity
-25% maintenance therapies
🎯 CC-0 not known …
Interesting subgroup analyses- see the thread 👇
@JAMASurgery
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Cytoreductive surgery with/without HIPEC should be standard of care of patients with resectable
#colorectalPM
In this month's case we will highlight some grey areas & controversies in the mx of
#colorectalPM
Here is a short series of polls
@kturaga
@alarjosan
@AndreasBrandl8
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OVHIPEC-1 final results
-Median follow-up 10.1y
-Benefit in PFS and OS persists
HIPEC
➡️Less platinum resistance (26% vs 40%)
➡️Less peritoneal recurrence (central radiology review)
➡️Cost effective
➡️No negative impact on QOL
@BatistaTP
@TDellingerMD
@bakrinna
NOW OF: In the final 10-yr survival analysis of the OVHIPEC-1 ph 3 RCT of cytoreductive surgery w/o vs w/ HIPEC in pts with adv ovarian cancer, median PFS was 10·7 months (95% CI 9·6–12·0) vs 14·3 months (12·0–18·5); HR 0·63 [95% CI 0·48–0·83], p=0·0008).
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The 2022 PSOGI consensus on HIPEC regimens - Colorectal cancer
Why should you follow this consensus??? ⬇️⬇️⬇️
'The expert panel consisted mainly of surgical oncologists and providers of CRS and HIPEC. This bias explains, to a certain extent, the surprisingly high degree of
@PSOGI_EC
@SPeritoneum
@ISSPP1
@MartinHbner3
@KurtSpeeten
@govaerts_kim
@glehenolivier
et al
Sound consensus : CPM & CRS HIPEC option 👍
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The recording for those who missed it!
U may have to register (free) to watch
@LanaBijelicMD
@oliviawriting
@FarazKh65499316
@SeguraJuanJ
@marjo_koskela
@RafaelSeitenfus
@docswapnil01
@DrFloresAyala
@BatistaTP
@Bhandoria
@JayrajAarthi
@NewsJellybelly
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Warming up for another interesting discussion
#PSOGICASE
@alarjosan
@AndreasBrandl8
@kturaga
@DeliaCortesGuir
@oliviawriting
@FarazKh65499316
@DrFloresAyala
@MrUmarShariff
@nabsansari
@jeetrohila
@anik0411
@RazaSayyed12
@RupenShahMD
@ISSPP1
@APeritoneum
@MISIRG1
@SPeritoneum
2
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Here we go
#PSOGICASE
M/45 years; no comorbidities
H/O right sided lower abdominal pain
Ultrasound: a RIF mass-with free fluid in the pelvis
Contrast CT: omental and peritoneal mets
Tumor markers –not tested
@MISIRG1
@SPeritoneum
@WimCeelen
@ISSPP1
@alarjosan
@FaheezM
1
12
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A procedure as rare as the disease itself- thoracic CRS for PMP
Join us for this interesting session
@LanaBijelicMD
@alarjosan
@DrFloresAyala
@DeliaCortesGuir
@drarturreis
@vivekanandkem
@paulo_sutt
@azizosurgeon
@nabsansari
@ChiaClaramae
@ClaEveno
@AT_surgery
@kturaga
0
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The customary poll before the discussion
@kturaga
@FaheezM
@LanaBijelicMD
@FarazKh65499316
@alarjosan
@AndreasBrandl8
@RafaelSeitenfus
@nabsansari
@MrUmarShariff
@RazaSayyed12
@sukumar_vivek
@RupenShahMD
@DeliaCortesGuir
@MISIRG1
@SPeritoneum
@vivekanandkem
@ChiaClaramae
1
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Microsatellite and RAS/RAF Mutational Status as Prognostic Factors in Colorectal Peritoneal Metastases Treated with Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (HIPEC)
@AnnSurgOncol
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A great day for the Twitter peritoneal oncology community
#PaulSugarbaker
@PSugarbaker
is now on Twitter
Stay tuned for some exciting discussions and deliberations on this subject!
@APeritoneum
@AssocAmarape
@PMPSurvivor
@acpmpresearch
@GynMe4
@indepso
@RENAPE_Network
@me4_so
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Read the results of the PSOGI consensus on HIPEC regimens for ovarian cancer ⬇️
🤝b/w gynec and surgical oncologists
🔸What indications?
🔸What regimens?
🔸Technical aspects of HIPEC
🔸What regimens to be used in clinical trials?
@zivanovicmd
@donalb5
@BatistaTP
@annafagottimd
Latest PSOGI Consensus on HIPEC for EOC peritoneal metastasis
Essential clinical decision support tool & basis for designing future trials
@glehenolivier
@writeslkpushkin
Oliver Zivanovic Donal Brennan Cédric Nadeau
@wvdriel
@bakrinna
➡️ (full text access)
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0
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Some relaxation after a long day of presentations and discussions!!
@dr_mohammadyami
@Hosni52Hosni
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The effect of intraperitoneal administration of BromAc on blood parameters: phase 1 study
@alarjosan
@VahanKepenekian
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1st results of the PSOGI consensus on HIPEC regimens have been published in
@AnnSurgOncol
#peritonealmesothelioma
#DMPM
@SPeritoneum
@ESSOnews
@AssocAmarape
@NoInvisibles
@SocSurgOnc
@KurtSpeeten
@VahanKepenekian
@oliviawriting
@kturaga
@RichardalexMD
@BatistaTP
@WimCeelen
Last PSOGI Consensus on HIPEC Regimens for Diffuse Malignant Peritoneal Mesothelioma
@AnnSurgOncol
➡ Robust methodology (GRADE, PICO)
➡ Almost 70 international experts
➡ 2 Delphi voting rounds
✔ Clear recommendations
👉
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Just a few days left
Join the discussion
@BatistaTP
@FranciscoMPerr1
@RupenShahMD
@DrFloresAyala
@Dr_Jamie_Murphy
@MPEngbersen
@sukumar_vivek
@FarazKh65499316
@AndreasBrandl8
@JohnnyOngCA
@yipjeremy
1
8
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Warming up for the last case of 2022!
Despite the rapid progress in💉💊, surgery continues to hold its ground in ovarian🦀& is still the🎯changer
The 1⃣time is the best time to treat ovarian🦀
#hitithard
A short series of polls..
@gyncsm
@IJGConline
@IJGCfellows
@SPeritoneum
2
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Revised schedule: 9th Dec Fri
10-11am EST
4-5pm CET
3-4pm GMT
8.30-9.30pm 🇮🇳
1-2pm 🇧🇷
@gyncsm
@Bhandoria
@IndiraRosero
@drsadiejones
@dr_ray2
@Elizabeth_Tremb
@Some4SurgeryIT1
@CNevrez
@BatistaTP
@AT_surgery
@docswapnil01
@SPeritoneum
@cascalescirugia
@ghanim_khatib
@alarjosan
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The DESTOP-3 trial published in the NEJM
“Habemus
#DESKTOP3
! Congrat to all authors; amazing effort to run a
#RCT
on surgical issues. 👉🏻 , via
@NEJM
.
@sbco_oficial
@br_gynoncgroup
@IGCSociety
@SGO_org
@ESGO_society
@ESSOnews
@SocSurgOnc
@OneBotSurgery
@Bhandoria
@glaucobaiocchi
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Here we go..
#PSOGICASE
@PSugarbaker
41y lady; asymptomatic
h/o rheumatoid arthritis
Incidental diagnosis of advanced EOC :Pelvic masses+ peritoneal spread
Bx-low grade serous carcinoma (ovarian origin)
CA-125: 36.0 IU/L
Gynec oncology consult➡️NACT for extensive pelvic dz
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Very pertinent question!
31% occult disease is high. That itself merits routine omentectomy. Stratification according to PCI would help - is these a subgroup where it’s not needed?
Authors conclusions very valid!!
Recurrence rate of 20% in residual omentum high: consider
Q3. Of 43 pts w/residual omentum, 24 (55.8%) recurred, including 9 (20.9%) with omental recurrence. Do you believe that routine omentectomy can help prevent recurrence and improve survival?
Is there a role for omentectomy in patients in which a CC0 during CRS can't be achieved?
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#KELIM
a new and robust biomarker for ovarian cancer to predict the outcomes of first line therapy
@benoityoulyon
@RENAPE_Network
@CHUdeLyon
@IJGConline
@BatistaTP
@agz_eriksson
@JayrajAarthi
@Bhandoria
@gyncsm
@GynMe4
@esragbilir
@AndreasObermair
@uppals
KELIM; ELIMination rate constant K
The KELIM score was indeed discussed at the GCIG Meeting 2023 in Chicago.
The introduction of this paper described the history of KELIM well.
@OncologyAdvance
#KELIM
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Poll
#1
For limited resectable colorectal PM (PCI<20) what is the preferred line Mx at your centre
@DeliaCortesGuir
@oliviawriting
@RupenShahMD
@almogby2
@AGangiMD
@nabsansari
@MrUmarShariff
@Hosni52Hosni
@mssalshahrani
@jeetrohila
@FranciscoMPerr1
@FaekJ
@GabrielleVanRam
Surgery upfront
16
NACT foll by surgery
20
Could be either
11
Surgery is not performed
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Just a day to go..
The customary polls before tomorrow's discussion
(🐤polls have limitations); tweetorial to follow!
@LanaBijelicMD
@alarjosan
@MrUmarShariff
@FarazKh65499316
@AndreasBrandl8
@vivekanandkem
@Dr_Jamie_Murphy
@DrFloresAyala
@CNevrez
@sukumar_vivek
@paulo_sutt
2
7
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Just a few hours to go!!!
Join the discussion right here on Twitter
With
@PSugarbaker
Follow
#PSOGICASE
@LanaBijelicMD
@kturaga
@alarjosan
@AndreasBrandl8
@FarazKh65499316
@RazaSayyed12
@DeliaCortesGuir
@oliviawriting
@ISSPP1
@SPeritoneum
0
5
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Time to replace IDS with ICS
Agree or disagree?
@gyncsm
@GynMe4
@ENYGO_official
@IJGCfellows
@IJGConline
@Bhandoria
@HsuMd
@BatistaTP
@gefcintra
@FlorenciaNoll
@agz_eriksson
@annafagottimd
@wvdriel
@bakrinna
@dchimd
@zivanovicmd
@TeamOvary_MSK
@indepso
One more study presented Today showing significant OS and PFS benefit of HIPEC in ICS+ HIPEC ca ovary
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Join us today with
@glehenolivier
5-6 pm CET
11-12 pm CET
9.30-10.30 pm IST
Right here on Twitter
Follow
#PSOGICASE
@LanaBijelicMD
@kturaga
@alarjosan
@AndreasBrandl8
@BatistaTP
@AGangiMD
@DeliaCortesGuir
@oliviawriting
@ISSPP1
@SPeritoneum
@jeetrohila
@Dr_Jamie_Murphy
0
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