N Molecular Systems
@Nth_step
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Recent advances reveal architecture of energy transduction systems in pathogens. Heme transporter CydDC promotes assembly/maturation of cytochrome bd (target for development of novel therapeutics). Cover depicts CydDC/heme embedded in bacterial bioenergetic membrane milieu.
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(1/3) Molecular defense systems: bacteria deploy motorized spindles to entangle & degrade viral DNA. Checkout this intriguing work!! Structure and mechanism of Zorya anti-phage defence system. Nature (2025) Image for: @NMITaylorLab Created by: N Molecular Systems | @Nth_step
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(2/3) Molecular defense systems: bacteria deploy motorized spindles to entangle & degrade viral DNA. Checkout this intriguing work!! Structure and mechanism of Zorya anti-phage defence system. Nature (2025) Image for: @NMITaylorLab Created by: N Molecular Systems | @Nth_step
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(3/3) Molecular defense systems: bacteria deploy motorized spindles to trap & degrade viral DNA. Checkout this intriguing work!! Structure and mechanism of the Zorya anti-phage defence system. Nature (2025) Image for: @NMITaylorLab Created by: N Molecular Systems | @Nth_step
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Molecular mechanism of substrate recognition and cleavage by human γ-secretase ▼ Science https://t.co/uQ9EU23ANR
science.org
Successive cleavages of amyloid precursor protein C-terminal fragment with 99 residues (APP-C99) by γ-secretase result in amyloid-β (Aβ) peptides of varying lengths. Most cleavages have a step size...
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"Dissecting the conformational complexity and mechanism of a bacterial heme transporter" | A passage for heme | Nature Chemical Biology, August 2023 Vol. 19 No. 8 Open Access pdf: https://t.co/a83WaFUVIh EMD-14640 | 7ZDB, ... https://t.co/BE4DBrZ9pq
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HEME TRANSPORTER. Decades-old enigma in bioenergetic membrane biogenesis. Max Planck's @MPIbp @SafarianSchara et al resolved CydDC in 23+ states/conditions 2.7-3.9Å by cryoEM, probing heme structural dynamics via mutations, 20 MD simulations. Image (2021, version B): @Nth_step
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Thank you to Max Planck @MPIbp and to Nature @nchembio for selecting the cover. It looks great in print! Congrats to all for the great work @MPIbp @ALIFE_VU @UGent @UniKent @MiChAeL_900922 @AhmadRezaMehdi1 @franziska_f1nke @sonjawelsch @ShepherdLabKent @HummerLab @SafarianSchara
The role of CydDC, a potential target for new antibiotics, in the bacterial energy metabolism has remained nebulous for decades. Scientists from our Institute, @ALIFE_VU, @UGent, @UniKent solved the riddle: CydDC is a heme transporter👉 https://t.co/qqkC21S97a
#biophysics #cryoEM
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Congratulations to Safarian lab at Max Planck @MPIbp !! It was a real pleasure working with you! @SafarianSchara @MiChAeL_900922
https://t.co/gmt8HdEOMT
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Congrats to @NogalesLab @Yildiz_Lab on insights into MAP7 & Kinesin-1 https://t.co/wJW8uNF0XB A warm flashback to our formative model (vis-a-vis 2018 "Microtubules: From Atoms to Complex Systems", EMBL) in collab with Ori-McKenney lab. #MAPs #kinesin #microtubules #cellpolarity
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Our collaboration on PYRD 310-helical element implicated in human disease & conserved in kinesin superfamily molecular motors, with McKenney/@ucdavisbiology @GennerichLab/@EinsteinMed Niwa/@TohokuUniPR
#AccelerateResearch, please read https://t.co/YP6zURj3rI
@KIF1A #KAND #KIF1A
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Intriguing aspect of the work @A_Amunts is 20Å gap between exit / insertase, providing for additional factors and #proteinfolding milieu (which differs from bacteria that favor early compaction of TM helices). We visualize 32 AA of #MTATP6 here (red) in place of poly-Ala in 6zm5.
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If a machine could talk to us, what would it say? #beautifulmachine #code #recursion #dance
https://t.co/PSjofuJalF
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