Nathan Owens
@NathanEqualsOne
Followers
2K
Following
2K
Media
335
Statuses
5K
Engineer and problem solver with an interest in nutrition and n=1 personal experimentation in diet, exercise and lifestyle. Alter-ego of @VirtuallyNathan
Redmond, WA
Joined June 2018
Love the window seat
The window seat on a plane is an incredible modern blessing. Imagine our ancestors getting to take in such a view. They would have been stunned, speechless. And yet, some close the shade and do what? My God. I can't understand those who shut the shade, and shut out the world.
1
0
8
Got my VO2Max as measured by indirect calorimeter over 60ml/min/kg!
0
0
7
“Commercial methionine restriction (MR) diets contain 0.17% methionine compared with normal levels of 0.86%, but notably, the MR diets also lack cystine” … what?!
1
0
2
Another Nature paper on Cysteine this week! “Cysteine depletion triggers adipose tissue thermogenesis and weight loss” https://t.co/4Q3tLnn3cw
@anabology @Joeb_AD
nature.com
Nature Metabolism - The authors describe how reduced dietary availability and systemic loss of cysteine leads to adipose tissue browning and rapid weight loss in mice and humans.
"Unravelling cysteine-deficiency-associated rapid weight loss" "conditional cysteine restriction resulted in the most substantial weight loss [...] amounting to 30% within 1 week. We found that cysteine deficiency activated the integrated stress response [...] leading to the
1
0
4
Human data: N = 59 participants with overweight or obesity (73% women) were randomized stratified by sex to an 8-week plant-based dietary intervention low (~ 2 g/day, SAAR) or high (~ 5.6 g/day, control group) in sulfur amino acids. SAAR led to a ~ 20% greater weight loss
pubmed.ncbi.nlm.nih.gov
gov/study/NCT04701346.
2
0
4
CoA scarcity stalls β‑oxidation and the TCA cycle, forcing a wasteful spill‑over of glycolytic and TCA intermediates into urine, amplifying the integrated‑stress‑response that drives GDF-15 and FGF21 transcription; more details in:
1
0
2
"Unravelling cysteine-deficiency-associated rapid weight loss" "conditional cysteine restriction resulted in the most substantial weight loss [...] amounting to 30% within 1 week. We found that cysteine deficiency activated the integrated stress response [...] leading to the
4
3
31
The list goes on. Am I missing something? This seems like totally useless nonsense?
1
0
5
I don’t really drink much anymore, nor do people in my family. I drank in college, but that’s about it.
1
0
3
Polygenic score time! Wow, 100%ile for migraines. Never had one, nor has anyone in my family.
1
0
2
I have even bigger plans
I have plans that I cannot share with you right now because the haters will sabotage me
1
0
4
If I order “whipped cream” and you give me “whipped topping” - straight to jail, no trial.
3
0
11