Michele Curatolo, MD, PhD
@MicheleCuratolo
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Physician, scientist, teacher, and leader in pain medicine. Professor at the University of Washington. Italian and Swiss. https://t.co/wyC5dMSkpp.
Seattle
Joined March 2019
The biggest enemy of knowledge is not ignorance, but the illusion of knowledge - Stephen Hawking
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Chronic pain after surgery: why it happens so frequently. #ChronicPain #Surgery @UWAnesthPainMed
https://t.co/AUEmGRvDca
michelecuratolomd.com
Surgery can lead to chronic pain, likely due to persistent nerve damage, inflammation, and alteration in the processing of pain signals in the spinal cord and brain.
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Impressive work by Sylvanus Toikumo, revealing cell-type-specific genetic architecture of human chronic pain across the nervous system. The C2 DRG from our patients with neck pain undergoing surgery displayed enrichment of pain-specific genes. https://t.co/aqoSPyWs2c
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The first paper from our project, which identifies gene expressions in the human DRG associated with neck pain. Fantastic collaboration with Ted Price's @UTDPainCenter, @Hofstetter_MD Neurosurgery, and a stellar team. Thanks @NIH_NIAMS @UWAnesthPainMed
https://t.co/pgE8t4lThw
academic.oup.com
Arendt-Tranholm et al. use surgically resected sensory ganglia to investigate the mechanisms underlying chronic neck pain. They produce a molecular map of
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A very exciting conference that brings together top scientists, clinicians, and biotech/industry experts to present emerging therapeutic targets for #ChronicPain. Learn more here: https://t.co/sX9dOvDFze.
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On #Biomarkers for #ChronicPain: Recent research shows that it not only about biological measures https://t.co/X6SRr3gE3e
michelecuratolomd.com
New research highlights the benefits of combining biological and psychosocial measures when identifying biomarkers for pain. This supports the biopsychosocial model and urges a holistic approach to...
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Dear X Friends, breakthrough: finally a treatment that works for patients with chronic #pain following #whiplash! Cost-effective treatment + reduced disability & symptoms immediately after treatment + at 1y follow-up: 🔓: https://t.co/9WWm02XlHo
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A short read on how #steroid #injections can help managing #ChronicPain, why they may be ineffective, and a frequently overlooked side effect they cause. @UWAnesthPainMed
https://t.co/zeHo0R7f9Z
michelecuratolomd.com
Steroids are commonly administered via injection to help manage chronic pain. But how do they work, and why do they often seem ineffective?
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Our study finding associations of cerebrospinal fluid metabolites with #ChronicPain in spinal muscle atrophy #SMA #metabolites #metabolomics @UWAnesthPainMed Cerebrospinal fluid metabolomics of pain in patients with spinal muscle atrophy
academic.oup.com
Dear Editor,
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The protocol of our multi-omics study in #LowBackPain and #Fibromyalgia. With Daniel Raftery's lab and Darrell Henze at @Merck . Aims: to identify molecular pathways potentially involved in these conditions, and identify #biomarkers. @UWAnesthPainMed
https://t.co/IQelnibkZ8
journals.plos.org
Background Chronic low back pain (CLBP) and fibromyalgia (FM) are leading causes of suffering, disability, and social costs. Current pharmacological treatments do not target molecular mechanisms...
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Chronic pain in older adults: Previous studies raised concerns about gabapentin + opioids causing death. New research sheds light on this. #chronicpain #opioids #overdose @UWAnesthPainMed @theclearcenter
https://t.co/fUUQ0CrXjK
michelecuratolomd.com
Gabapentin may not increase the risk of death when used with opioids, but its safety profile warrants cautious use.
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A great opportunity to learn about #mechanisms of #pain from the intervertebral disc at#USASP2025. #LowBackPain #ChronicPain #Research @UTDPainCenter
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The FDA approval of @VertexPharma #suzetrigine is a groundbreaking development. Hopes for patients with pain, and a lesson to pain researchers. #PainManagement #DrugDevelopment @UWAnesthPainMed
https://t.co/EPtuquTG6x
michelecuratolomd.com
In a groundbreaking development, the FDA has approved Vertex's suzetrigine for the treatment of moderate to severe acute pain. This approval marks the introduction of a pain medication to the market...
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Review: Chiu, @LesnakJoe, @_KatherinG18, @pavlosbob, @UTDPainLab @Arendt_Nielsen, & @MicheleCuratolo conducted a scoping review on the human mechanisms of discogenic #LowBackPain — Identified an inflammatory-nociceptive feedback loop Full:
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Our scoping review on the mechanisms of #LowBackPain from the intervertebral disc, focusing only on human studies with pain outcome data, has identified an inflammatory-nociceptive feedback loop. @pavlosbob @UTDPainLab @Arendt_Nielsen
https://t.co/uxHTp8qs62
jpain.org
The limited understanding of the mechanisms underlying human discogenic low back pain (DLBP) has hampered the development of effective treatments. While there is much research on disc degeneration,...
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I have been skeptical about the effectiveness of muscle relaxants in chronic pain, but a new study changed by mind. #ChronicPain #Medications
https://t.co/aAkM4cxJ5c
michelecuratolomd.com
Muscle relaxants can help manage chronic pain, but not reliably and not in all types of chronic pain.
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For those who cannot access the New York Times, here a short summary of the outstanding article on #ChronicPain with contributions from @robgereau and other great colleagues. https://t.co/F24D8LHTro
michelecuratolomd.com
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https://t.co/ELQ2OMhnPG Extremely well written article by Jennifer Kahn in the @nytimes, highlighting challenges and hopes in #ChronicPain. Grateful for the opportunity to contribute. @UWAnesthPainMed @uwmnewsroom
nytimes.com
As many as two billion people suffer from it — including me. Can science finally bring us relief?
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Great paper indeed, thanks for leading @JoNijsBE and happy to have contributed!
Dear X Friends, our 2021 @TheLancetRheum paper received the ‘highly #cited paper’ label from @Clarivate Essential Science Indicators, as it received enough citations to place it in the top 1% of the academic field of Clinical #Medicine: https://t.co/wCGzzlwFUw
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Gabapentin and pregabalin prescriptions have skyrocketed in the last years. New data challenge their widespread use. #ChronicPain #Pain #Medication
https://t.co/kNtayCGE3u
michelecuratolomd.com
Gabapentin and pregabalin are likely overprescribed for pain. They offer pain relief in some patients ,but often cause adverse effects.
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Our latest study in @TheJournal_Pain identifies key inflammatory pathways, like TNF-α and NF-κB signaling, as targets for future therapies. A big step towards personalized pain management. @MicheleCuratolo
Human molecular mechanisms of discogenic low back pain: A scoping review 👇👇👇 https://t.co/R3F2W3m7WE
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