McGinley-lab
@McGinleyLab
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Joined October 2018
1/9 New preprint on the strategic allocation of processing recourses in mice, and the role of pupil-linked arousal (. Led by @jwdegee. A thread.
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9/9 Thus, increases in task utility motivate mice to pay more attention, helped by the stabilization of arousal. Shoutout to @bcm_neurosci, @TCHResearchNews and @NIH for support.
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8/9 Crucially, after increases in task utility, mice do not stereotypically up- or down-regulate arousal but stabilize their arousal state towards its optimal (intermediate) level.
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7/9 Corroborating our earlier findings, we show that optimal signal detection behavior occurs at intermediate levels of arousal.
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6/9 By applying quantitative modeling we show that during high utility, mice accumulate perceptual evidence across longer timescales (lower leak), more efficiently (higher drift rate), and more reliably (lower attentional lapse rate).
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5/9 We report that after increases in task-utility, mice lick more, but especially during signals vs. noise sounds – a behavioral hallmark of attention.
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4/9 We developed a feature-based “attentional intensity task” with non-stationary task utility for head-fixed mice and report behavioral and pupillary signatures of strategic attentional intensity allocation in a large cohort (N=88 mice; n=1983 total sessions).
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3/9 Neuromodulatory systems control the cortical arousal state and shape information processing. Pupil size at constant luminance tracks arousal. We asked if mice regulate attentional intensity to exploit increases in task utility, and what role pupil-linked arousal plays.
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2/9 Attentional intensity describes the intuition that students in a classroom setting will be motivated to “pay more attention” when the instructor indicates the next section will be on the exam, which should lead to improved behavioral performance.
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RT @bcm_neurosci: Dr. Matthew J. McGinley & team in the Dept. of Neuroscience at BCM & Duncan Neurological Research Institute at TCH featur….
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RT @donner_lab: 1/ How do modulatory neurotransmitters such as catecholamines and acetylcholine influence large-scale cortical activity cor….
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RT @donner_lab: If you're interested in brainstem imaging, neuromodulators, and cognition, come watch the #OHBM2021 presentation by @jwdege….
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RT @DrAxonHunter: I’m proud to present our work on vagus nerve stimulation in mice, now online in @CurrentBiology! Check it out and let me….
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RT @kahn_martin: Cool new preprint on interactions between Locus Coeruleus , sleep spindles and infraslow oscillations. Especially cool how….
biorxiv.org
The continuity of non-rapid-eye-movement sleep (NREMS) is essential for its functions. However, many mammalian species, including humans, show NREMS fragility to maintain environmental vigilance. The...
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RT @SFB_936: Choices 🍏🍎are less biased in high arousal (👁️pupil-linked) states. Seems to be a general principle.across species👤🐭.for direc….
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New paper from the lab on mechanisms and biosensors of vagus nerve stimulation, out now in @natcomms. Great team effort! @bcm_neurosci @BCMFromtheLabs @TCHResearchNews.
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RT @ctenigmavar: Thanks to @McGinleyLab for this nice preview of our recent Current Bio paper!
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RT @andermann_mark: New Dispatch from @McGinleyLab ( on studies of arousal-related modulation of activity in retin….
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RT @tania_barkat: Super proud of our new study reporting the effect of attention, arousal, reward and movement in 4 different nuclei along….
biorxiv.org
Sensory processing varies depending on behavioral context. Here, we asked how task-engagement modulates neurons in the auditory system. We trained mice in a simple tone-detection task, and compared...
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