Mayo Amyloid
@MayoAmyloid
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Twitter account for the Mayo Clinic amyloidosis group
Joined September 2018
RT @Myeloma_Doc: #Myeloma Paper of the Day: Mayo Clinic Consensus Statement on heart transplantation for #amyloidosis (including AL/light c….
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By @MattReesMD.
New in @Haematologica: early post-chemo AL BM amyloid plaques of pts in >=vgpr show ↓ immunoglobulins & ↑ complement + SAP. Anti-fibril mAbs may lose efficacy post-FLC clearance. Complement activation may worsen toxicity. #Amyloidosis 1/.
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RT @Taxkourel: Very disappointed to see a second antibody fail in #amyloidosis. Interested to see the subset that b….
astrazeneca.com
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RT @RahulBanerjeeMD: Great @BloodCancerJnl RW data from US #MMsm consortium, led by @DimaDanai @leshune et al!. BCMA bsAbs can work in BCMA….
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🧬 Large multi-center study (n=572) shows >=VGPR at 6 months post-ASCT predicts superior OS & PFS in AL #amyloidosis. Early CR = best outcomes. Pre-ASCT dFLC ≤10 mg/L also linked to longer PFS. Supports using early response to guide post-ASCT strategy.
pubmed.ncbi.nlm.nih.gov
Autologous stem cell Transplant (ASCT)-related mortality (TRM) in AL amyloidosis remains elevated. AL amyloidosis patients (n = 1718) from 9 centers, transplanted 2003-2020 were included. Pre-ASCT...
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🫀 In AL #amyloidosis, deeper cardiac responses (CarR) drive survival—but what predicts them? High BM plasma cells ≥20%, kappa isotype, & HR FISH → faster, deeper CarR—independent of hematologic response. Suggests light-chain toxicity matters.
pubmed.ncbi.nlm.nih.gov
Cardiac response (CarR) is associated with survival in AL amyloidosis, but substantial variation exists in response kinetics. We investigated variables associated with deep CarRs to characterize the...
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Real-world data confirms: adding daratumumab to CyBorD in AL amyloidosis improves outcomes. ✅ Higher VGPR+ (78% vs 60%).✅ Fewer early deaths (6-mo: 8.8% vs 16.3%).✅ Better 2-yr OS (82% vs 70%).Best OS boost in stage II. #amyloidosis #mmsm
pubmed.ncbi.nlm.nih.gov
In the ANDROMEDA phase 3 trial, the addition of daratumumab to cyclophosphamide, bortezomib, and dexamethasone (Dara-CyBorD) as frontline therapy significantly improved hematological and organ...
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In a study of 130 AL #amyloidosis patients with liver involvement, hepatic response rose from 28% at 6 mo to 48% at 24 mo. High baseline ALP (≥4× ULN), deeper hematologic response, kappa type, and frontline ASCT were key predictors of response
pubmed.ncbi.nlm.nih.gov
The degree of baseline ALP elevation and HemR are reliable predictors of HepR.
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RT @LadanZand: The Mayo MGRS Prediction Tool calculates the risk of finding monoclonal gammopathy of renal significance in a kidney biopsy….
kidney-international.org
Monoclonal gammopathy of renal significance (MGRS) is increasingly recognized as an important cause of kidney failure. A kidney biopsy remains an important diagnostic measure. However, a kidney...
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RT @JLRosenthal: Please share this exciting and interactive Amyloid case based seminar w/your fellow Amyloid champions and trainees. @Bre….
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RT @Cornerstone_CME: IT'S TIME! The 2nd Annual #ATTR Early-Career Research Forum abstract submission window is open!. Submit here for a cha….
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RT @rajshekharucms: Lack of RCT data on ASCT in AL Amyloidosis (+ ⬆️ TRM vs myeloma) makes decisions tough when VGPR/CR post-DaraVCd. This….
nature.com
Bone Marrow Transplantation - A model for predicting day-100 stem cell transplant-related mortality in AL amyloidosis
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RT @Taxkourel: Great work by @MattReesMD on proteomic determinants of renal response in AL #amyloidosis (need inst….
pubmed.ncbi.nlm.nih.gov
Proteomic determinants of renal organ response in light-chain amyloidosis
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We are accepting applications for the #Amyloidosis Fellowship @MayoAmyloid. Supported by @Amyloidosis_ARC , with the goal of training expert clinicians while fostering opportunities for clinical and translational research. @Taxkourel @MorieGertz @myelomaMD @ADispenzieri.
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RT @Taxkourel: Now accepting applications for the #Amyloidosis Fellowship @MayoAmyloid. Supported by @Amyloidosis_ARC , with the goal of tr….
college.mayo.edu
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RT @abouezzeddine: Most excited bout this long awaited collab! A unique, first of kind opportunity to leverage AI-powered quantum imaging t….
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RT @MelissaLyleMD: Excited to share @MayoClinic experience with #amyloid and🫀transplant.📌 Post tx survival #amyloid = non-amyloid pts .📌….
onlinelibrary.wiley.com
Background The prognosis in patients with advanced cardiac amyloidosis (CA) remains poor. Objectives We sought to describe survival post heart transplantation (HT) in amyloid compared with non-amy...
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