Matthias P. Wymann
@MatthiasWymann
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Need a chemical probe from @DepBiomedicine @UniBasel to explore PI3K signaling? See @ChemicalScience our newest article on a highly cell permeable covalent PI3Kalfa inhibitor: "Rapid, potent, and persistent covalent chemical probes to deconvolute PI3Kα signaling".
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Covalent Proximity Scanning of a Distal Cysteine to Target PI3Kα - congrats Chiara Borsari, your paper made > 10000 article views!
pubs.acs.org
Covalent protein kinase inhibitors exploit currently noncatalytic cysteines in the adenosine 5′-triphosphate (ATP)-binding site via electrophiles directly appended to a reversible-inhibitor scaffold....
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Post-doc positions in Medicinal Chemistry, 100% for more info see and apply at https://t.co/GeRpEzUC1E Project relevant, recent publication of our lab see https://t.co/WbqyCfRNAP
pubs.acs.org
Covalent protein kinase inhibitors exploit currently noncatalytic cysteines in the adenosine 5′-triphosphate (ATP)-binding site via electrophiles directly appended to a reversible-inhibitor scaffold....
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The role of PI3Kγ in the immune system: new insights and translational implications @NatRevImmunol by @lucasite_lab & @MatthiasWymann covers #Genetics and #drugdiscovery of #PI3K Now online at https://t.co/kQbSBUOFMz
nature.com
Nature Reviews Immunology - This Review discusses the immunomodulatory properties of phosphoinositide 3-kinase-γ (PI3Kγ) in health and in the context of various diseases, ranging from...
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Novel roadmap to target distal cysteines in kinases disclosed: covalent PI3Kalfa inhibitor in @BorsariChiara et al. @MatthiasWymann @DepBiomedicine@UniBasel_en @J_A_C_S #MedChem #CovalentProbes #StochasticApproach #rationaldrugdesign is online at
pubs.acs.org
Covalent protein kinase inhibitors exploit currently noncatalytic cysteines in the adenosine 5′-triphosphate (ATP)-binding site via electrophiles directly appended to a reversible-inhibitor scaffold....
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