
Matteo Carandini
@MatteoCarandini
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Neuroscientist at UCL. My opinions. No longer tweeting. Moved to @[email protected] and https://t.co/cEI15ESd79
London, UK
Joined June 2016
I plan to close my Twitter account on 31 December 2022. People who follow me please find me at
mastodon.social
713 Posts, 650 Following, 1.94K Followers · Neuroscientist at UCL (#UniversityCollegeLondon). Opinions my own. Posting mostly about #Neuroscience.
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Does cortex use the same neurons across tasks?. Task specificity in mouse parietal cortex. by @synapticlee with Michael Krumin and @kennethd_harris .
The brain meets a myriad behavioral demands with a limited number of neurons. Does it use the same neurons across behaviors? We addressed this question in mouse parietal cortex, where neurons are thought to be multitaskers. The results surprised us… 1/n.
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Out today!. Neural correlates of blood flow measured by.ultrasound.
Functional ultrasound imaging (fUSI) reveals large fluctuations within & across brain regions. @anwarnunez and Michael Krumin found that these fluctuations accurately reflect the underlying neural spikes. With @charureddy @opto_brain_imag @kennethd_harris .
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This was exactly 1.5 years ago, and it worked: @NeuroCellPress is now Open Access (a Transformative Journal in @cOAlitionS_OA lingo). This battle is won. Next: Article Processing Charges, which are too high at some journals. Easiest way to lower them is for funders to set limits.
A letter to Elsevier from 79 members of the Board of Neuron. We urge Neuron to transition to full Open Access. @ElsevierConnect @NeuronCellPress @cOAlitionS_OA.
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Functional ultrasound imaging (fUSI) reveals large fluctuations within & across brain regions. @anwarnunez and Michael Krumin found that these fluctuations accurately reflect the underlying neural spikes. With @charureddy @opto_brain_imag @kennethd_harris .
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Congratulations to Mika Diamanti! Her PhD work is now all published. 1/2 in 2018 . 2/2 today! . Spatial modulation of visual responses arises in cortex with active navigation. w @charureddy @sylvia_schroed @Aman_sal & al.
elifesciences.org
Spatial modulation along the visual pathway arises in the cortex and strengthens with active navigation and experience.
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So, @synapticlee discovered that neurons in parietal cortex are specialists, active only in specific physical contexts. The brain allocates different neurons to different tasks, even where neurons were thought to multitask. Read all about it: .
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So, is it the physical context that determines specificity? To this this rigorously, @synapticlee trained mice in a THIRD, hybrid task: mice steer a wheel to rotate their view in virtual reality. The answer was unequivocal: specificity depends on physical context. 6/n
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While mice performed the tasks, @synapticlee recorded from hundreds of neurons in parietal cortex. To our surprise, neurons were specialized! Neurons that responded in one task were largely silent in the other, and vice versa. 3/n
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Congratulations to @ggFedericoRossi for discovering a circuit for selectivity in the cortex! . Out today in @nature (. With @kennethd_harris @UCLBrainScience @UCLeye @UCLIoN . Funded by @wellcometrust and @fightforsightUK.
nature.com
Nature - In the mouse visual cortex, the excitatory and inhibitory presynaptic neurons of individual layer 2/3 pyramidal neurons are spatially offset to generate direction-selective responses.
(1/n) What circuit generates selectivity in L2/3 cortical neurons? We answer this question in our paper:. Spatial connectivity matches direction selectivity in visual cortex . out today in @nature with @kennethd_harris and @MatteoCarandini.
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Lecture 3.2 - Combining Neuropixels with imaging - by Andrew Peters @flickerfusion @UCLeye @UCLBrainScience . Lecture 3.3 - Combining Neuropixels with optogenetics – by Maxime Beau @maxime_beau @NeuralCompLab @uclmedsci 7/n.
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Lecture 2.4 - Using Kilosort's graphical user interface - by Nick Steinmetz @SteinmetzNeuro @UW . Lecture 2.5 - Curating sorted spikes with Phy - by Nick Steinmetz @SteinmetzNeuro @UW 6/n.
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Lecture 2.2 - Practicalities of Neuropixels recordings 2 – by Nick Steinmetz @SteinmetzNeuro @UW . Lecture 2.3 - Spike sorting with Kilosort – by Marius Pachitariu @marius10p @HHMIJanelia 5/n.
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Lecture 1.6 - Practicalities of Neuropixels recordings – by Sylvia Schröder @sylvia_schroed @SussexNeuro Lecture 1.7 - Planning a Neuropixels trajectory – by Andrew Peters @flickerfusion @UCLeye @UCLBrainScience 4/n.
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Lecture 1.4 - Recording across the brain with Neuropixels - by Nick Steinmetz @SteinmetzNeuro @UW . Lecture 1.5 - Science with large recordings - by Kenneth Harris @kennethd_harris @UCLIoN @UCLBrainScience 3/n.
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Lecture 1.2 - Introduction to Neuropixels – by Matteo Carandini @UCLeye @UCLBrainScience . Lecture 1.3 - The technology in Neuropixels – by Carolina Mora Lopez @imec_int 2/n.
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We have posted an updated preprint, with some cool new results. (1/3).
biorxiv.org
During navigation, the visual responses of neurons in primary visual cortex (V1) are modulated by the animal’s spatial position. Here we show that this spatial modulation is similarly present across...
We are excited to share our latest work: “Spatial encoding in the visual pathway arises in cortex and depends on active navigation”. Now on bioRxiv: Summarised in the series below.
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