Our latest work has been published in @BioinfoAdv ProCogGraph, the spiritual successor of PROCOGNATE. This graph database provides a linkage between proteins domains (SCOP/CATH/Pfam) and cognate ligands for #enzymes in the #PDB.

🚨🚨Paper out! 🚨🚨 Delighted to share our work, now published in @NatureGenet 🧬! https://t.co/7KJpQBsLWq We identified a targetable, chromothripsis-associated genetic event in blast phase (BP) MPN, a particularly poor prognostic subtype of acute leukaemia. 1/n 🧵👇

I am no longer active on this platform, you can find me where the sky is bluer under the same handle.

Proud to announce we're working with @Lenovo and @Logicalis to deliver the new Higgs high-performance computing (HPC) cluster to put Northumbria at the forefront of technological innovation and further boost research excellence. 🖥️Discover more: https://t.co/sNsvQlJab7

If you find this work interesting I'm currently looking for a new PhD student, see the Add here

Interestingly if we look at promiscuous superfamilies' (those binding multiple ligands) we find they can fall into "generalised" - binding a wide range of chemically diverse ligands or "specialised" - binding some very chemically similar ligands, categories.

This the work of my PhD student Matt Crown, one of the nice things he did was this t-SNE plot of cognate ligand space within the PDB, in which we see some nice clusters of related compounds.

⚙️ "ProCogGraph: A graph-based mapping of cognate ligand domain interactions" advances protein-ligand studies w/ a robust graph database, enhancing protein docking & design by mapping cognate ligand interactions. https://t.co/6PzBO8l7cL #ProteinInteractions #LigandMapping

Are you interested in studying above and belowground interactions and the allotment-soil-microbiome? Then why not apply for this great PhD opportunity @NorthumbriaUni https://t.co/5QFK8DxtVC

See our latest paper in Angewandte Chemie where we use microbial division of labor to enhance photocatalysis @ReisnerLab @RahamanM_Chem

This work builds on our latest publication in Bioinformatics Advances

Please RT, come do a PhD with me as part of an industrial collaboration with P&G using metagenomes and AI to design new enzymes https://t.co/IWjD6NqCxL #pLMS #AI #enzymes #Bioinformatics

Academics will have a 2 hour conversation about how busy they both are that ends in them agreeing to co-write something new

📃 New research from @cjrIllingworth & colleagues found that having Air Cleaning Units in place was associated with a 22% lower risk of hospital-acquired #COVID19 virus infection, during a hospital stay of typical duration. More info: https://t.co/x6uaIjJ3y5 @MRC_BSU @CUH_NHS

Friendly reminder that if you want to contribute to science, release your code/models. Not (just) a server with 10 daily jobs. A system like AlphaFold —built on "public goods" provided for free— must be equally open to the scientific community in response https://t.co/KMqobl1Bnm

💰 We are very proud to receive funding from @UKRI_News as part of its work to tackle infections. The "One Health Computational Network" will focus on predicting, detecting, and preventing viral diseases that threaten humans, animals and plants. More: https://t.co/1JNABxrsTd

Morning

Can’t hope for better than this in October! Pint? You’ll have to carry it to your table yourself mind!

So @JeremyFarrar asked for an "explainer thread" on Noble Prizes in Chemistry around AlphaFold and Protein design, so here goes.

We are so proud of our city 🖤 There was a lot of concern across the city that we would experience disorder and violence tonight. Instead we saw a Newcastle united by love, hope and pride in our city. This is our City. A City of Sanctuary 🤝 https://t.co/c1oIz2UEtx