Gregory Wu
@MS_ResearchDoc
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Physician-scientist. Neuroimmunologist. Multiple Sclerosis specialist. @WUSTLmed
St Louis, MO
Joined October 2018
🚨 Paradigm shift in #MultipleSclerosis 🚨 New study in Nature Medicine shows MS is not fixed subtypes but a dynamic continuum of states across 4 dimensions: disability, brain damage, relapses & silent inflammation. 📖 Read: https://t.co/MYvAAI6AiV
#MS #Neurology #AI
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CSF cell analysis is key to understanding neurological diseases but has been limited by cell fragility. Millet Wallisky et al. introduce a rapid, one-step method for efficient CSF immune profiling Check out the paper below 👇 https://t.co/loCOZF1gVX
jni-journal.com
Flow cytometry analysis of the cerebrospinal fluid's immune cell subset profiles can be used to help in the diagnosis and prognosis of nervous system pathologies. However, the cells need to be...
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Murphy Lab Bay #2: proving that science and chaotic shenanigans can coexist. 🙌 @SunnyKimNov2016
Scientists have found that C/EBP⍺ activates an IRF8 #enhancer, driving its expression in early myeloid progenitors and specifying type I conventional #DendriticCell lineage. @washu_pathology @JingNeticist Read more in Science #Immunology: https://t.co/stvtqL9ZPb
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Pleased to write this editorial with Larry Steinman about a potential novel antibody in MS https://t.co/pSkJlvM9OU Original manuscript here: https://t.co/LzndcCZ6SA
neurology.org
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Happy to share this collaborative work looking at long term results of a high efficacy DMT in early #MS #ocrelizumab @OMRF @AaronBosterMD @drbarrysinger @Brandon_Beaber @MSViewsandNews
neurology.org
Background and ObjectivesPatients with multiple sclerosis (MS) may demonstrate better disease control when treatment is initiated on high-efficacy disease-modifying therapies (DMTs) from onset. This...
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So proud of this collaborative work! Thanks to all involved, including @Clodida @BrianEdelson2 @maxim_artyomov @mzhlab @jsabatino37
1/ I am thrilled to share our latest paper: A single-cell compendium of human cerebrospinal fluid identifies disease-associated immune cell populations, @jclinicalinvest! Thanks to @MS_ResearchDoc, @BrianEdelson2, @maxim_artyomov, and co-author Roma for this collaborative effort!
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@mzhlab I am proud to share our manuscript published in @ANA_journals today. 🥳 https://t.co/Ho4jcUhqhv We used data-driven approaches to analyze paired #CSF and blood #FlowCytometry of 8,790 (discovery) + 3,201 (validation) patients. A #tweetorial 🧵1/16
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Exciting news! Our new paper is published at Annals of Neurology! Check it out to see how large-scale CSF and blood flow cytometry can reveal disease clusters to improve diagnosis and understanding https://t.co/JzIIUSuKVn
onlinelibrary.wiley.com
Objective Cerebrospinal fluid (CSF) provides unique insights into the brain and neurological diseases. However, the potential of CSF flow cytometry applied on a large scale remains unknown. Method...
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Using sc-RNA-Seq to delineate T cell changes in AD, demonstrates an up regulation of exhaustion markers in CD8+ T RM cells within 5xFAD mouse brain. Check the link below 👇 https://t.co/64Zjm72BSj
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I'm excited to announce that Jennifer Lawrence's thesis work is now out! Check it out here: JCI Insight - Microglia drive diurnal variation in susceptibility to inflammatory blood-brain barrier breakdown
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Post-mortem MS brain display PD1+ Granzyme B+ tissue-resident memory (Trm) T cells in MS lesions, in contact with EBV infected B cells promoting local CNS inflammation. Check out👇 this 2023 interesting study from @FrancescaAloisi
https://t.co/1TfrE0xwiG
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@MS_ResearchDoc @KateSadlerPhD Another super important TRP paper that I just came across because of a new paper on how fever impacts CD4 T cell responses by @DarrenHeintzman. Linking the TRPV paper here to add it to this thread: https://t.co/cRlW1sNuk4
pubmed.ncbi.nlm.nih.gov
Fever is a conserved and prominent response to infection. Yet, the issue of how CD4 T cell responses are modulated if they occur at fever temperatures remains poorly addressed. We have examined the...
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Excessive and repetitive Ampicillin treatment alter the gut-brain axis. Ampicillin induce neuroinflammation through NfL, NOS2 and GFP release. Check out 👇 the work by @TouilBoukoffa team. https://t.co/aB17x8K8fY
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Incredibly excited to share our latest work exploring the antigen specificity of clonally-expanded CSF-enriched CD8+ T cells in MS #multiplesclerosis #Tcells #EBV 🧵1/ https://t.co/8modGjmFBY
biorxiv.org
CD8+ T cells are the dominant lymphocyte population in multiple sclerosis (MS) lesions where they are highly clonally expanded. The clonal identity, function, and antigen specificity of CD8+ T cells...
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Incredibly excited to announce that the program will be growing. For 2025, we will be matching 13 applicants (From 11) to a categorical @WashUNeurology PGY-1 position. Ultimately, the program will expand from 44 to 52 residents! @TheNRMP #match2025 #neurotwitter #MedTwitter
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Soluble NCAM-1 and VCAM-1 as potential biomarkers for cognitive decline in inactive primary progressive MS. #CognitionDecline #MultipleSclerosis #PPMS #Biomarkers #Onestepforward #CarloscamaralemarroyLab
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Please RT! My lab is recruiting a Specialist to join us on several exciting new projects related to T cells in MS and novel therapeutic targets. Ideal applicants should have flow cytometry experience. Apply here:
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