At least two beautiful new studies out this month show very compelling evidence for a direct role of Systemic Genomic Instability (SGI) in cancer development (thread)

New #GENETICS paper from @GusWaneka, @SloanEvoLab et al shows UV damage produces #mitochondrial DNA of specific length occurring at characteristic locations. Read more about how this work can unravel new mitochondrial DNA degradation & repair mechanisms: https://t.co/wNtaIYTKJd

Amazing science and traditional hike at FASEB "Genetic Recombination and Genome Rearrangements 2024" conference in Tucson, AZ. Such a beautiful location!!!

During #eukaryotic sexual reproduction large segments of homologous chromosomes cross over.  In a new #GENETICS study, researchers identified an interaction between Dmc1 recombinase and endonuclease complex required for crossover resolution in 🍞 yeast: https://t.co/70jMCPeidF

Olá #eshg2024 ! We have a postdoc position open to study #structuralvariation in #rarediseases! Please contact me directly or apply here

Celebrating with the lab: 3 DECLINED NSF-GRFPs, 9+ PhD program admission offers, 1 PostDoc job offer. Ups and downs, all part of the journey!

Also Saturday night: PosBac Joy Love (Poster 622S) will show her work to redevelop and optimize our bioinformatic pipeline for precise LOH detection from yeast WGS data.

Saturday night: PhD student Joey Stewart (Poster 1726S) will show his super cool phylogenetic analysis of single cell lineages that directly demonstrates the occurrence of LOH bursts in diploid yeast.

Friday night: PostBac Camryn Schmelzer (Poster 1697F) will present her work on developing a powerful new experimental system to study half-crossover cascades in S. cerevisiae.

Super bummed out to be absent at #TAGC24... I will miss them, but YOU can check out 3 great posters from our lab. All 3 from fantastic soon-to-be-former lab members; all 3 are headed to fabulous grad school or postdoc training by fall.

Do you work on chromosome biology and cell cycle in yeast? Join us for an exciting meeting! https://t.co/XYoaI8TEg0 Please RT

They explained to me that, a “good noodle” star is given in recognition for high academic achievement, in Mrs. Puff’s classroom in SpongeBob Square Pants. I’m so honored to finally receive this prestigious award!

I requested a translation to one of the undergraduate researchers working in my lab, who of course, knew exactly the meaning.

Yesterday I received the course evaluations from the students who took the freshman-level course I taught in Fall 2023. It contained the following feedback gem from an anonymous student: “Professor Argueso is a good noodle.”

We have postdoctoral positions open (see ad below). Projects involve DNA damage signaling mechanisms and development of novel approaches to interrogate kinase/phosphatase action in cells. Come join our lab! Please share / apply.

I am so excited to read this new work on mutational bursts and systemic genomic instability in yeast! Congratulations @G__Fischer and team!

Here is our latest work in which we developed a method to map ssDNA contacts during DNA break repair in yeast. Homology search is not uniform along the ssDNA, the genome, and over time. We could define the mechanisms of its uneven expansion genome-wide🧵 https://t.co/yepXyA8f7N

Happy holidays from the JL Argueso lab! Celebrating successful defenses and grad school applications submitted! 🤞

Exciting news: Hot off the press is the work of @lara_alz and Marine S on genome instability and LOH in intestinal stem cells @institut_curie funded by @WorldwideCancer, FRM, and @AgenceRecherche Cell Reports

Glad to share our @emboreports review about break-induced RNA-DNA hybrids (BIRDHs) where we discuss results, what we can learn and question remaining. @unisevilla @CancerCSIC @CSIC https://t.co/6S93c1zicr

The week has arrived! It is finally here! The week all scientists wait for all year long! #FatBearWeek ! Let's all vote 151 Walker - This is our year! https://t.co/5wQYuwnksx