Michael Lohse
@LohseNeuro
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Neuroscientist. Sir Henry Wellcome Postdoctoral Fellow at the Sainsbury Wellcome Centre/UCL, Champalimaud Centre for the Unknown, and Stanford University
London, UK
Joined July 2018
Proud to share our paper in @Nature that Andrei and I co-first authored with @TFlogel @SWC_Neuro We recorded ~15000 neurons across the brain while mice made perceptual decisions to reveal how sensory evidence controls actions through global neural dynamics
nature.com
Nature - Brain-wide recordings in mice show that learning leads to sensory evidence integration in many brain areas simultaneously, allowing sensory input to drive global movement preparatory...
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Thrilled to see our work published in Science today! Grateful for the opportunity to collaborate with an amazing team at @SonjaBHofer Lab and @SWC_Neuro . Years of effort went into this project—excited for what’s ahead! :)
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“Where was I again?” Our study published today https://t.co/SssPQUDv7l reveals brain cells can form a coordinate system for our behaviours. Instead of locating where we are in the world, this coordinate system tells us “where we are” in a sequence of behaviours: 🧵below:
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Neuroscientists at SWC (@UCL) and @NDCNOxford (@UniofOxford) reveal how brain cells form a coordinate system for behavioural sequences. Read the news ⬇️ https://t.co/lA4Sl8Xb22
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📢 Opportunity Alert! We have two open PhD positions in our lab at @PDN_Cambridge starting in Autumn 2025. Exceptional candidates may have the opportunity to join earlier as RAs and receive PhD funding if scholarship applications are unsuccessful. Advert: https://t.co/fFdNGTqqQk
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Come by our poster today at SfN (board U7). I’ll be there all afternoon to take you through our findings showing a frontal corticostriatal mechanism for cognitive control of sensorimotor transformations.
Come and hear about our research! Today, @LohseNeuro, @lijingjiepoi and Yaara Lefler are all presenting posters at #SfN24
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Come and hear about our research! Today, @LohseNeuro, @lijingjiepoi and Yaara Lefler are all presenting posters at #SfN24
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Will you be at #SfN24? Stop by our posters and talks! Stay tuned for more details 👀 @SfNtweets
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Here it is! A huge milestone in neuroscience – the complete connectome of the fly brain from the FlyWire team (@FlyWireNews). In this special issue, we have 9 research articles. I’ll try to summarize them in a couple threads starting here 🧵
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Applications now open! Join the SWC PhD Programme 2025 🧠 World-class training in systems neuroscience 💰 Fully-funded 4-year programme 💂 Based in London with close links to @GatsbyUCL Learn more and apply by 11 Nov: https://t.co/8g0atYhP2g
#PhD #Neuroscience
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@orsoliva This work could not have been done without the funding from @wellcometrust and the Gatsby Charitable Foundation, and the supportive, collaborative, and inspiring environment @SWC_Neuro
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This has been a highly collaborative effort, and we thank @orsoliva, Ryan Low, Tadej Bozic, Paige Windmill for invaluable help with discussions, insights, behavioural design, animal training, preprocessing, and modelling to make this paper what it is!
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This allows evidence integration and motor planning to happen without causing movement. The commitment to action results in a rapid state transition that translates the accumulated evidence into movement, which we show occurs almost instantaneously throughout the brain.
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By adopting a framework from the motor control field that describes neural dynamics surrounding movement, we show that evidence integration and preparatory activity across the brain exist in a population subspace that is orthogonal to movement execution activity.
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We reveal that sensory evidence integration and preparatory activity preceding movement are coupled processes, taking place within specific subpopulations of neurons across distributed premotor circuits.
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By comparing neural responses in naïve and expert mice across the brain, we show that the existence and dynamics of sensory evidence integration is established by learning.
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We find that integration of visual evidence is a surprisingly widespread process, taking place in the majority of brain areas outside the visual system.
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What is the nature of sensory prediction error signals in the neocortex? Our research published in @Nature reveals that these error signals are amplified responses to unexpected inputs, mediated by a cooperative thalamocortical circuit mechanism! 1/4 https://t.co/fS9ztjB1St
nature.com
Nature - Experiments in mice show that a cortico-thalamic circuit generates prediction-error signals in primary visual cortex that amplify visual input that deviates from animals’ expectations.
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@ShoheiFurutachi's heroic study on sensory prediction errors in visual cortex is out at @Nature now, including a lot more exciting data:
nature.com
Nature - Experiments in mice show that a cortico-thalamic circuit generates prediction-error signals in primary visual cortex that amplify visual input that deviates from animals’ expectations.
Prioritising the unexpected: SWC researchers reveal how the brain responds to unexpected events 🧠 Read the news ⬇️ https://t.co/V2eiCKbSJp
#Neuroscience 1/3
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Are you working with in vivo optogenetics? Ever wondered what the impact of shining laser light within the brain in the absence of exogenous opsins has on neuronal activity? PLEASE SEE https://t.co/XS4TV867KE & READ 🧵👇 work done @SWC_Neuro, thx Mateo Velez-Fort & Troy Margrie
biorxiv.org
Genetic engineering of exogenous opsins sensitive to a wide range of lightwavelengths allows the interrogation of brain circuits to an unprecedented temporal and spatial precision. In particular,...
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