Ligandal
@Ligandal
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Ligandal creates AI-driven peptide sequences capable of targeting specific cells/tissues and is developing bioinspired nanomaterials for non-viral gene therapy.
Brooklyn, New York
Joined August 2013
Andre Watson, CEO of Ligandal (@nanogenomic), presents at @PMWCintl 2025 to discuss AI-driven predictive, personalized, and preventative therapeutic delivery of next-generation biomedical technologies.
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This technology is poised to transform the industry and the future of medicine by integrating diagnostics with therapeutics. Ligandal separates the "where" (target) from the "what" (function) to design targeted drug and gene delivery systems.
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Predictive Interactomics® integrates with single-cell RNA sequencing and proteomics data to give insights into how diseases impact organs and tissues, and create custom-tailored targeting approaches.
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Targeting: Target Identification: Ligandal can target approximately 1,000 receptors using 360,000 predicted targeting ligands. Customizable: You can submit a query on Ligandal's website to receive customized cellular targeting approaches.
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Delivery: • Delivery Modality Agnostic Technology: Ligandal's technology can be linked to lipid nanoparticles, biologics, or drugs. • Payload Agnostic: It can deliver mRNA, DNA, CRISPR, and silencing RNA.
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Key aspects of Ligandal's Predictive Interactomics®: • Generative AI: Ligandal employs an internal generative AI to design peptides that accurately target specific cellular markers. • Physics-Based AI Model: The AI model is physics-based and resistant to hallucinations.
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Targeted Delivery: Current drug and gene delivery methods resemble "carpet bombing," while Ligandal enhances them to be "laser precise."
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Ligandal develops LigandAI®, using Predictive Interactomics® and its advanced delivery technologies, to accurately target cells and tissues for research and enhance therapeutic delivery. This is akin to the invention of shipping routes and GPS.
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The ribosome lowers the entropic penalty of protein folding https://t.co/ytlD7Hvawk
nature.com
Nature - Structures of the growing peptide chain on and off the ribosome reveal that the ribosome destabilizes the unfolded nascent chain, promoting the formation of partially folded intermediate...
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Ligandal is at the forefront of genetic medicine, focusing on oncology, rare disorders, and biodefense with our non-viral gene therapy platform. With Tushar's leadership, we're set to amplify our mission of bringing transformative therapies to world. #FutureOfMedicine
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Tushar's achievements speak volumes: spearheading transactions exceeding $2 billion and launching impactful products across the industry. His roles, spanning from Pfizer to Novartis, highlight a legacy of strategic vision and innovation. #DrivingInnovation
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📢 Exciting times at Ligandal! We welcome Tushar Nuwal as our Chief Operating Officer and Chief Business Officer. With 20 years of experience in the biopharmaceutical sector, Tushar is poised to strengthen our endeavors in genetic medicine. #LigandalLeadership
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