Really cool new paper "The tRNA-GCN2-FBXO22-axis-mediated mTOR ubiquitination senses amino acid insufficiency" at @Cell_Metabolism ! An entirely new way in which mTOR senses AA deficiency Thanks @pak_heidi for pointing out this one. Tweet added by Lamming Lab @LammingLab

Lamming Lab

7 months

Really cool new paper "The tRNA-GCN2-FBXO22-axis-mediated mTOR ubiquitination senses amino acid insufficiency" at @Cell_Metabolism ! An entirely new way in which mTOR senses AA deficiency Thanks @pak_heidi for pointing out this one.

The tRNA-GCN2-FBXO22-axis-mediated mTOR ubiquitination senses amino acid insufficiency

Ge et al. unravel a novel mechanism of amino acid sensing by mTORC1, in which amino acid depletion-caused accumulation of uncharged tRNAs stimulates GCN2 to phosphorylate FBXO22, which in turn...