Alexis Vallée-Bélisle
@LaboAVB
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Prof. Chimie @UMontreal; Titulaire @CRC_CRC en Bio-ingénierie et Bio-nanotechnologie; Co-founder Anasens #startup #Nanotechnology #Biosensors #Chemistry
Université de Montréal
Joined October 2022
RT @J_A_C_S: Programming the Kinetics of Chemical Communication: Induced Fit vs Conformational Selection | Journal of the American Chemical….
pubs.acs.org
Life on Earth depends on chemical communication and the ability of biomolecular switches to integrate various chemical signals that trigger their activation or deactivation over time scales ranging...
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3) Thanks to Carl-Prévost Tremblay, Achille Vigneault, and @DomLauz for their hard work on the project. Thanks also to the funding agencies: @NSERC_CRSNG, @FRQ_NT and @ProteoQuebec.#DNA #RNA #ChemicalBiology #protein #sensor #Nanotechnology #SyntheticBiology #Nanomachines.
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1) Latest work from the lab (in @J_A_C_S): : how nature programs the kinetic of its molecular systems and to use this information to build better nanotechnology. Link to article:
pubs.acs.org
Life on Earth depends on chemical communication and the ability of biomolecular switches to integrate various chemical signals that trigger their activation or deactivation over time scales ranging...
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3) Merci à Carl-Prévost Tremblay, Achille Vigneault et @DomLauz pour leurs contributions à ce projet. Un grand merci aux organismes subventionnaires: @NSERC_CRSNG, @FRQ_NT et @ProteoQuebec.
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1) Les derniers travaux du labo (dans @J_A_C_S): comment la nature programme la cinétique de ses systèmes moléculaires et comment utiliser ces stratégies pour développer de meilleures nanotechnologies. Lien vers l’article:
pubs.acs.org
Life on Earth depends on chemical communication and the ability of biomolecular switches to integrate various chemical signals that trigger their activation or deactivation over time scales ranging...
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Congrats @DomLauz and thanks to the funding agencies: @NSERC_CRSNG, @FRQ_NT, @ProteoQuebec, @NSERC_PROMOTE, @TIPS_SPIIE #CRC (3/3).
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Briefly, using simple DNA-based models, we illustrate how molecular assemblies may have evolved to create complex self-regulating functions ranging from improved cooperativity to self-inhibition while demonstrating the thermodynamic framework to create such nanosystems. (2/3).
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Life is sustained by thousands of different self-assembled nanomachines. How were these systems created, programmed, and fine-tuned to support life? See our latest paper in @angew_chem, which may also inspired the design of new nanotechnologies: (1/3).
onlinelibrary.wiley.com
Molecular assembly can be designed by fusing binding domains. A precise optimization of the level of compaction of the assembly using linker of different lengths or compositions can provide a simple...
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Félicitation à @DomLauz et merci aux organismes subventionnaires: @NSERC_CRSNG, @FRQ_NT, @ProteoQuebec, @NSERC_PROMOTE et @TIPS_SPIIE #CRC. (3/3).
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Petit résumé. Avec des modèles simples d'ADN, on montre comment ces assemblages moléculaires ont pu évoluer pour créer des fonctions autorégulatrices complexes allant de la coopérativité à l'auto-inhibition, le tout, en expliquant le cadre thermodynamique pour les créer. (2/3).
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La vie est soutenue par des milliers de nanomachines auto-assemblées, mais comment ces systèmes ont-ils été créés, programmés et réglés pour soutenir la vie ? Voir notre dernier article dans @angew_chem : (1/3).
onlinelibrary.wiley.com
Molecular assembly can be designed by fusing binding domains. A precise optimization of the level of compaction of the assembly using linker of different lengths or compositions can provide a simple...
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RT @angew_chem: Design and Thermodynamics Principles to Program the Cooperativity of Molecular Assemblies (Alexis Vallee-Belisle and co-wor….
onlinelibrary.wiley.com
Molecular assembly can be designed by fusing binding domains. A precise optimization of the level of compaction of the assembly using linker of different lengths or compositions can provide a simple...
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(5/5) Un gros merci à @AlexGelle d’avoir si bien vulgarisé nos travaux. Merci (thanks) aux organismes subventionnaires: @NSERC_CRSNG, @FRQ_NT, @ProteoQuebec & @NSERC_PROMOTE.
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(4/5) Pour lire l’article original publié dans / To read the main article published in @J_A_C_S:
pubs.acs.org
The emergence of life has relied on chemical communication and the ability to integrate multiple chemical inputs into a specific output. Two mechanisms are typically employed by nature to do so:...
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(2/5) Our @J_A_C_S paper was selected among the top 10 discoveries of 2023 in @QuebecScience! Dive into the secrets of chemical communication and molecular languages:
nouvelles.umontreal.ca
Université de Montréal scientists recreate and compare molecular languages at the origin of life – opening new doors for the development of novel nanotechnologies.
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(1/5) Les travaux de doctorat de @DomLauz réalisé à @UMontreal se retrouvent parmi les 10 découvertes de l'année 2023 de @QuebecScience! Plongez dans les secrets de la communication chimique et des langages moléculaires:
nouvelles.umontreal.ca
En 2023, parmi les 10 découvertes québécoises mises à l’honneur par le magazine «Québec Science», 3 sont le fait d’équipes de l’Université de Montréal dans les domaines de la chimie et de la médecine.
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Congrats again to @DomLauz and thanks to the funding agencies: @NSERC_CRSNG, @FRQ_NT, @ProteoQuebec, @NSERC_PROMOTE, @TIPS_SPIIE and to editor @SleimanHanadi at @J_A_C_S (3/3).
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