Wyllie lab @dundee
@LabWyllie
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We determine the mode of action of compounds with potential to treat neglected tropical diseases. Opinions are my own.
University of Dundee
Joined May 2019
Delighted to be awarded the 2023 CA Wright medal for outstanding contribution to parasitology by the @BSPparasitology. Huge thanks to all my mentors and collaborators. Extra special thanks to group members (past and present) - 100% a group award. @WCAIRDundee @UoDLifeSciences.
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RT @ByDonkeys: While we’re talking about politicians and tax, a reminder that Nigel Farage works for a company that exists to help rich peo….
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Today's paper writing sound-track is Neil Diamond! What have I become??.
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New paper alert! Oldie but goodie from the Fairlamb lab. Thanks to @FairlambAlan for coordinating! @UoDLifeSciences @WCAIRDundee
journals.plos.org
Author summary Over 75 years have passed since the discovery of “ Crithidia factor” – biopterin – as an essential cofactor involved in several important metabolic functions in mammalian cells....
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RT @Ariel_Lab: Very interesting paper on the pterines in Tryps. In my TODO list for the weekend! Well done @LabWyllie and @FairlambAlan htt….
journals.plos.org
Author summary Over 75 years have passed since the discovery of “ Crithidia factor” – biopterin – as an essential cofactor involved in several important metabolic functions in mammalian cells....
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RT @ScienceTM: A new series of #quinazoline compounds can neutralize #Tcruzi and related parasites by targeting the enzyme KRS1 and has par….
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RT @DrBhambra: A true testament to collaboration in science with @LabWyllie and many more wonderful colleagues - our work in drug developme….
science.org
Quinazolines targeting Trypanosoma cruzi lysyl-tRNA synthetase show partial efficacy in a mouse model of acute Chagas disease.
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Delighted our latest paper is now published in Science Translational Medicine. Fantastic collab with @DrBhambra and his team. Our studies reveal promising quinazolines selectively target KRS in T. cruzi. @DundeeLifeSci @WCAIRDundee .
science.org
Quinazolines targeting Trypanosoma cruzi lysyl-tRNA synthetase show partial efficacy in a mouse model of acute Chagas disease.
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Fantastic paper from MoA group alumni Richard Wall and colleagues. 🙌
nature.com
Nature - The validation of inhibitors targeting PurF, a novel drug target for tuberculosis drug discovery, is described.
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RT @CombatNTDs: Well done to Papua New Guinea 🇵🇬 on eliminating trachoma as a public health problem. This success is a powerful example of….
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New paper alert! Our work to determine the molecular target of a thienopyrimidinone demonstrating anti-malarial activity. Congrats to Natalie Wiedemar who led this work.
pubs.acs.org
Chemotherapy remains a key component of the arsenal of tools to fight malaria. Specifically, new drugs with diverse mechanism(s) of action are required to combat existing drug resistance. Here, we...
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RT @RollingStone: A new study models the impact of the implosion of U.S.-funded disease treatment and prevention in the developing world —….
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Fantastic evening listening to the inspiring @dmac68 in St Andrews last night. Amazing stories and science.
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RT @goldenpipette: I'm excited to share that the lab has been awarded a Career Development Award from the @wellcometrust . £2.9 million for….
pawlowiclab.org
Dr. Mattie Christine Pawlowic Dr. Mattie Christine Pawlowic is a Principal Investigator and Sir Henry Dale Fellow. Her group is a member of the Wellcome Centre for Anti-Infectives Research at the U…
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PubMed website is down. Does anyone know if this is a technical issue or due to the lunatics at DOGE?.
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RT @mariellaf1: Can’t wait to see the tsunami of bile this will induce. Ready steady GO bots and the inarticulate…
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