Schellenberg Lab
@LabSchellenberg
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DNA repair lab at the Mayo Clinic
Joined September 2019
This was an awesome collaborative team effort by scientists from @MayoClinic @mayoclinicbmb @MayoGradSchool @MayoCancerCare @newcastleuni and the faculties of Pharmacy and Medicine at Charles University.
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Topobexin is an inhibitor that targets Topoisomerase IIβ's ATPase domain—protecting the heart from anthracycline chemo damage without reducing anticancer power. Read our article about this potentially game-changer in cardio-oncology @natcomms.nature.com
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RT @mpgoetz: Endoxifen is known to be a more potent inhibitor of ER alpha compared to tamoxifen. Based on an unbiased proteomic screen, we….
pubmed.ncbi.nlm.nih.gov
Endoxifen, a secondary tamoxifen metabolite, is a potent antiestrogen exhibiting estrogen receptor alpha (ERα) binding at nanomolar concentrations. Phase I/II clinical trials identified clinical...
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RT @AmandaRiccioPhD: We are so excited to present “Structural insight and characterization of human Twinkle helicase in mitochondrial disea….
pnas.org
Twinkle is the mammalian helicase vital for replication and integrity of mitochondrial DNA. Over 90 Twinkle helicase disease variants have been lin...
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RT @AmandaRiccioPhD: Alpha fold definitely has its uses, it’s great starting model, but then there’s oligomerization, conformational change….
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RT @GregDodge9: One of my fav lab hacks: store your E coli pellets in freezer bags. They freeze in 5 mins, resuspend in under 3 mins (in th….
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Excited to have a preprint of my labs first paper out. Who says protein preps have to be boring and clear? Add some colour! It’s about more than just how it looks.
biorxiv.org
Mammalian cell lines are important expression systems for large proteins and protein complexes, particularly when the acquisition of post-translational modifications in the protein’s native environ...
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Happy to be part of this really cool project that was made possible by the diverse expertise and collaborative environment at the Mayo Clinic. We are very proud of this!
biorxiv.org
Despite extensive research, the specific factor associated with SARS-CoV-2 infection that mediates the life-threatening inflammatory cytokine response in patients with severe Covid-19 remains...
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RT @Freudlab: New PI Lesson #508 - be very clear when providing the title of your seminar. 🤦♂️ #needmoresleep #sicktoddler .
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DNA science at Mayo!.Yes, it’s Lit and has a major groove on!
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RT @zha_lab: We are excited to welcome the 2022 Spring Speakers for the Social DNAing Webinar! Let us the Science continue! Thank you for a….
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3/4 one person in a position of power decided these #scientists and #engineers were not worthy of being trusted to follow the rules of their visa??? It’s OK, I’m sure their decision had nothing to do with the spouse’s brown skin.
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2/4 to block their spouse from joining them in this country? We force this brilliant scientist to choose between family and their research, and they end up leaving for another county, which is a loss for our institution, the State of Minnesota, and the United States. All because.
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