GloverLab
@LabGlover
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We study the regulation of cell division, focusing on centrioles, centrosomes and MTOCs. Lab news from @Caltech
Pasadena, USA
Joined August 2017
This predicts that the counterpart protein functions the same way in human cells and may have relevance to human cancer, where centriole duplication goes out of control. [3/3].
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Our research in the fly, suggests that the Ana1 adopts different structures for each of these processes. We show this by generating different variant proteins that could restore centriole duplication to ana1 mutants, but not centriole elongation required to make flagellae. [2/3].
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Centrioles are tiny cellular structures that have dual lives, they form the core of the two bodies that enable chromosomes to be shared between dividing cells or they move to the cell surface to template formation of cilia or flagella. [1/3].
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š¢** New Paper Alert**."Interactions of N- and C-terminal parts of Ana1 permitting centriole duplication but not elongation".
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Adelaide was a world expert in Drosophila meiosis and the best fly geneticist in the Department. She left a technicianās position in the Ashburner lab to join us as research associate and made pioneering contributions to our genetic studies of Greatwall kinase and its substrates.
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We are very sad to hear of the passing of Adelaide Carpenter, who had been in Genetics at Cambridge for over 30 years working mainly in our lab. A former full professor at UCSD, Adelaide came to Cambridge on sabbatical and never returned. Continued below.
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š¢ ** New Paper Alert**. We show that centriole 9-fold microtubule symmetry is not essential for centriole elongation, correct distribution of the centrioleās components along its length, and in initiating aspects of centriole duplication. @NatureComms.
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RT @AlexisLSperling: I have a new parthenogenesis paper with @LabGlover!. We found that aneuploidy arises during development in natural Droā¦.
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RT @CytoLabKoc: Just got a sneak peek at the group photo from #Centrosomes2023 in Taksim Square! 240 brilliant scientists from around the gā¦.
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RT @ManuelTHERY: Pallavi Panda broke my heart @centrosomes2023 by showing that centrioles work just fine even without their beautiful nine-ā¦.
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**New Paper**.
I am excited to share the final version of our work on the genetic basis of virgin birth (parthenogenesis) in fruit flies! It was a joy working with @DK_Fabian @erikgarrison @LabGlover on this understudied phenomenon.
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RT @AlexisLSperling: Prepare to be amazed: some parthenogenetic flies reproduce as larvae and the offspring burst forth from their mother iā¦.
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RT @CSHANews: It was nice meeting everyone at the #CSHAsia #Cilia & #Centrosomes Meeting. We hope everyone had a good time with us and haveā¦.
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RT @CytoLabKoc: Centrosome tweeps, "Centrosomes in Development, Disease and Evolution" hybrid meeting will be in Istanbul on 26-29 Septembeā¦.
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RT @focalplane_jcs: Happy #FluorescenceFriday!. This is a captivating image from @Levente87 @LabGlover @Caltech. Their work discusses the eā¦.
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Farewell to our fabulous summer students, Hanna & Buraq! Happy that they had an enriching Summer in the lab exploring centrosomes/cilia, as much as we enjoyed their curious, youthful spirit!
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Such beautiful clarity of the microtubule triplets and 9-fold symmetry š.
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