Many conserved exons in the heart and brain utilize weak 5 ′ splice sites, yet they are accurately spliced. But how? https://t.co/8pIpyxS9v4 https://t.co/7L3IafZBjD

And special thanks to @jakub-zeman.bsky.social who did the tough part of winding up the paper from our side. Digging out all old data and finishing up the last parts while rebuilding the lab

Very thankful to our collabortors especially the labs of Michael Sattler, Arjun Ray, Dumbovic lab, and Christian Münch @MuenchLab @goetheuni @CPI_ExStra @SCALE_Uni_FFM

Two outstanding first authors—one African American, one Chinese national - led by an Indian-German PI and an American PI. A glimpse of what diverse backgrounds can do for discovery.

This study is an equal partnership between my good friend and better scientist, Eric Van Nostrand’s lab at Baylor, and my lab. https://t.co/X3PublRh8h https://t.co/RuTCumbqUm

Mechanistically, we define a U6-complementarity rule that predicts QKI dependence, establishing a U6-anchored splice-fidelity checkpoint at weak 5'SS. QKI binds donor-proximal introns, directly engages U6, and, with U4/U6·U5 tri-snRNP, secures exon inclusion

V asked 2 fundamental Qs: How does the spliceosome achieve precision and specificity when confronted with insufficient/weak splice sites? how widely expressed RBPs, which recognize widely present motifs, are able to exert specific control in the right place and at the right time?

Sargent is a transformation- and cluster-free cell-type annotation method that operates at individual cell resolution by applying a scoring system to scRNA-seq data based on sets of marker genes associated with cell types. https://t.co/KqM9GC0qxP from my colleague Nima.

There is a lack of general terminology for translated regions that does not depend on the properties of their products or their sequence. Spearheaded by Pavel (Pasha) Baranov, this primer provides a unifying nomenclature for translation units: *Translon* https://t.co/G78Tmgc21e

Excited to have 3i Intelligent Imaging Innovations @3i_inc on board as a sponsor for #GEF25, celebrating 10 years of Expansion Microscopy. Great to team up with cutting-edge imaging specialists as we look ahead. 🔗 https://t.co/A8ujv01ugZ

Check this beauty from @incaRNAtolab

@BerndPulverer @Magda_Skipper @kaythaney @jimmy_wales One of the issues I had hoped to raise in the panel I was in was that misconduct is done by people, not because people are inherently bad, but because of the pressure to publish, the pressure of a demanding/bullying PI, from universities or even the government. #FutureSciPub

Architectural RNAs: blueprints for functional membraneless organelle assembly: Trends in Genetics

When sanity of Science is questioned without evidence by political decision makers, darkness looms over humanity.... If u can speak up, do so. If not, your children could LIVE The Handmaid's tale https://t.co/63Fwqz1blT

Unfortunately I have to delete the original thread (screenshot) because the "Pacmanoid" depiction of our discoveries - despite of course being completely original artwork - apparently could lead to copyright concerns. Full thread with different image: https://t.co/Mc2mmcl8Gn

What a human! https://t.co/Y1qBtCY9hD

We just wrapped up the NCBS-@jkscientists internship, a program designed to provide hands-on experience & mentorship to aspiring scientists. This year, we had 10 students from Kashmir join us in different labs @NCBS. We wish them all the best for their journeys ahead! @NeuroSeq

Thanks @NCBS_Bangalore ,for providing this life-changing opportunity to these trainees. It is a great feeling to see them get started and grow! I look forward to meeting them in person on March 18th! More details soon! @jkscientists

1/2 Early development requires fit cells. Following @MTorrescnic & T. Rodriguez, led by @JoshiFrenster we've developed a #gastruloid model #CellCompetition https://t.co/RPgCDrmdOe that recapitulate cell competition as in the embryo & open up experimental possibilities

After decades of destroying the environment, humans are back to destroying each other.