Marlen Knobloch
@KnoblochLab
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Laboratory of Stem Cell Metabolism, Lipid droplets in neural stem cells during development and adulthood, Glial metabolism in health and Alzheimer's disease
Lausanne, Switzerland
Joined March 2022
We are finally moving to Bluesky as well! Hopefully seeing many of you from here over there too! I’m looking forward to exciting science posts and discussions. @knoblochlab.bsky.social
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Dear #LipidDroplet friends, we just launched the website for the next #EMBOLipidDroplets Workshop in September 2025. Check out the amazing lineup of speakers. Abstract submission deadline is 10 June 2025. Hope to see many of you there! #organelles
meetings.embo.org
Lipid droplets are master regulators of nutrient and energy homeostasis, but their functions go far beyond these classical roles: They are important in cellular differentiation and various stress res…
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🚨#JobAlert🚨 Join us in Geneva @unige_en! We have an open #postdoc position starting in 2025. If you are interested in studying chromatin regulation and working with brain organoids, apply now! #sciencejobs More info: https://t.co/sX4ANFzRCu
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Our Faculty Position Opportunity in Metabolism in the school of Life Sciences at EPFL is still open...If your main research topic is metabolism (wet or dry lab), have a look and apply! Women, please also apply 😉, we need you here!💪 https://t.co/MtYbUP5RVy
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#Job alert! Are you searching for a #PhD position? Are you a #microglia lover and want to study these cells in #neurodegeneration? Join our team in the beautiful #Lausanne! Send me your CV, a motivation letter and two reference letters by Sept 28: rosachiara.paolicelli@unil.ch
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We can now detect them (almost) as good as in the tdTom-Plin2 mouse with commercially available reagents! And we found an absolutely stunning number of #LipidDroplets in the normal aged mouse brain! Have a look at Figure 6/Suppl. Fig.5/6!
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After seeing so many #LipidDroplets in the healthy young brain with our fluorescent LD reporter mouse ( https://t.co/bc0VFBheHQ), we wondered why they have not been seen in young brains from wildtype mice.
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https://t.co/16MKBFz9fh Check out our newest manuscript on #BioRxiv, where we provide an optimized method to visualize lipid droplets in wildtype mouse brain tissue! A special congrats goes to the shared first authors @PhDPetrelli and @Alicia__Rey!
biorxiv.org
Lipid droplets (LDs) are cellular stores for lipids. These organelles have recently gained interest in neuroscience because they accumulate in various cell types in neurodegenerative diseases....
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@DoetschLab @denisjabaudon @LudovicTelley 5.) We also show that LDs in the developing mouse brain are abundant and react dynamically to exogenous lipids, using ex vivo live imaging. In summary, a great tool to study the role of LDs in the brain, from development, adult to aging! This will keep us busy for years!! 😊
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@DoetschLab @denisjabaudon @LudovicTelley 4.) We demonstrate that this approach can be combined with subsequent scRNA Sequencing and show that there is a population of microglia that already contain many LDs at 2 month of age.
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@DoetschLab @denisjabaudon @LudovicTelley 2.) We show that LDs are abundant in various cell types in the healthy developing and adult brain to a much larger extent than previously thought! 3.) We took advantage of this model, crossed to several GFP reporter lines, to FACS cells according to the presence/absence of LDs
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@DoetschLab @denisjabaudon @LudovicTelley 1.) We generated a fluorescent LD reporter mouse by tagging endogenous Plin2 with tdTomato, resulting in red LDs in all the tissues expressing Plin2. We validated this model extensively under normal and short high fat diet.
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Congratulation again to all the authors and especially to Sofia Madsen! Great collaborations with the @DoetschLab, @denisjabaudon and @LudovicTelley labs 👏🍾 Short summary below:
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https://t.co/bc0VFBheHQ Excited and proud to see the final version of our manuscript out @NatureComms, describing a new lipid droplet reporter mouse, which allows staining-free fluorescent visualization of #LipidDroplets!! Check out how numerous they are in the brain!
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Eurogenesis is back! 🔥 Join us in Bordeaux, France from June 12th-14th for Eurogenesis 2024 - an immersive experience in adult neurogenesis research. Save the date for groundbreaking discoveries and insightful discussions! Register at: https://t.co/VTygyt7Uhv
#Eurogenesis2024
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Are you looking for a #postdoc position in #microglia biology? Interested in understanding how #TDP43 controls microglial function and #lipid handling in models of #demyelination and #remyelination? Consider applying to our lab and join us in #Lausanne! https://t.co/8w6UVnNPM8
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Please re-tweet! We're searching for a Drosophila lab technician! Interested in Drosophila as a model to study metabolism & lipid biology? Please DM for details. Ideal position for recently graduated undergraduates interested in research experience prior to grad school.
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#JobAlert We are recruiting a laboratory technician for an #Innosuisse funded academia-industry project! Check out the details and how to apply here: https://t.co/YA3wTmqbMd
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#JobAlert Post-doctoral positions in the field of neural stem cell metabolism available in my lab! Check here for more details and how to apply: https://t.co/6kTLnl90j2 Looking forward to meeting highly motivated candidates, please spread the word and RT! #lipiddroplets #brain
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📢Job alert! 🚨 Postdoc position between @CHUVLausanne and @hug_ge, on the exciting topic of mapping the #glymphatic system at #7T in the human brain, and translation to #CognitiveDecline. With: @GiovanniFrisoni @VGaribotto & myself @CIBM_ch @hnp_geneva
https://t.co/vM5eUXpgio
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