Klann Lab
@KlannLab
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Neuroscience lab investigating the molecular mechanisms of memory and how these mechanisms are disrupted in a variety of cognitive disorders.
New York University
Joined July 2019
Check out @prerana123's exciting paper on sex-specific differences in anxiety-like behaviors in TSC. Amazing amount of work using multiple approaches. Many thanks to all of our collaborators!.
Thrilled to share our new work on the neural mechanisms underlying pathological anxiety in Tuberous Sclerosis complex. Great teamwork from @neuro_living, @Lawdex01, @RodrigoTrianaD2, @ksanagustinr, @Mauricio_Neuro +others in @ShresthaLab & @KlannLab. (1/n)
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So happy for @Mauricio_Neuro, whose paper was published over the weekend. He shows how eIF2alpha becomes dephosphorylated in response to neuronal stimulation, answering a long-standing question in the field. Congratulations Mauricio!.
cell.com
Oliveira et al. demonstrate that sharp increases in protein synthesis resulting from neuronal activation require GADD34-induced eIF2α dephosphorylation. GADD34 expression is tied to the regulation of...
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Big week for @Muhaned711 and the lab. On Monday, his first, first author paper was published in PNAS. Today, he gave an outstanding presentation and successfully defended his Ph.D. thesis. Muhaned rocks - we are all proud to have had the opportunity to do neuroscience with him!
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Excited to share @Muhaned711's now published work describing the impact of epilepsy- and ASD-associated mutations in EEF1A2 on de novo translation, elongation, tRNA-binding, and actin bundling. Congratulations Muhaned!
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Delighted to share @DrJessicaAlapin's exciting work on an optogenetic tool that can be used to block eIF4E-dependent translation in specific cell types in the brain. Many thanks to all former/current lab members for their help in pushing this through!
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Thrilled to share @fran_longo17's latest work describing cell type-specific disruption of striatal circuitry in FXS. Many thanks to our collaborators in the labs of @CarterAG, @BagniLab, & @NicTritsch - sometimes it takes a village!
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Really excited to share @Mauricio_Neuro's latest work, where he describes a novel mechanism for eIF2alpha dephosphorylation in response to plasticity-inducing stimulation, answering a long-standing question in the field of neuronal translation. Congrats!
biorxiv.org
Neuronal protein synthesis is required for long-lasting plasticity and long-term memory consolidation. Dephosphorylation of eukaryotic initiation factor 2α is one of the key translational control...
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RT @BagniLab: Two open postdoc positions at @BagniLab @DNF_neuro! We are seeking for motivated candidates to investigate the mechanisms und….
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Excited to share @Muhaned711's work, where he describes how three separate ASD- and epilepsy-associated mutations in the gene encoding eEF1A2 alter translation elongation, neuronal morphology, tRNA binding, and actin bundling.
biorxiv.org
Protein synthesis is a fundamental cellular process in neurons that is essential for synaptic plasticity and memory consolidation. Here, we describe our investigations of a neuron- and muscle-speci...
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Happy to share @fran_longo17's work describing how cell type-specific changes in striatal MSNs drive repetitive behaviors in FXS mice. Many thanks to @CarterAG, @NicTritsch, & @BagniClaudia labs for sharing their expertise!
biorxiv.org
Individuals with fragile X syndrome (FXS) are frequently diagnosed with autism spectrum disorder (ASD), including increased risk for restricted and repetitive behaviours (RRBs). Consistent with...
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RT @DirkTrauner: Check out our paper on the optical control of translation with a puromycin switch - in neurons! A collaboration with @tong….
pubs.acs.org
Translation is an elementary cellular process that involves a large number of factors interacting in a concerted fashion with the ribosome. Numerous natural products have emerged that interfere with...
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RT @prerana123: Thrilled to share our review on the modulation of emotional and social behaviors by oxytocin.signaling in limbic network!!….
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RT @EmoryGenetics: Stephen T. Warren Memorial Symposium Nov 29-30, 2022 @EmoryMedicine -- honoring giant in #fragilex + repeat disorders fi….
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Today at @NYU_CNS, @erin_schuman gave the Valle Foundation Visiting Professor Lecture, where she discussed her groundbreaking work on local neuronal translation. Erin's talk was amazing - we are very excited to host her for an entire month here in NYC!
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The EMBO Workshop on RNA Localization and Local Translation held in Sant Feliu De Guixols, Spain concluded today. What a great meeting! Many thanks to @BassellLab, @ChaoLabFMI, Anne Ephrussi, and Geraldine Seydoux for organizing!
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Congratulations to Harrison Evans, who was awarded a Research Fellowship from @alzassociation to fund his exciting work on translation dysregulation in neurodegenerative disease!.
Yesterday I was thrilled and extremely grateful to find out that I had been awarded the @alzassociation. Research Fellowship. This funding will support my work within the @KlannLab exploring how impairments in protein synthesis contribute to various forms of dementia. #ENDALZ.
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RT @tongil_ko: Excited to share our work on the optical control of translation and monitoring of newly synthesized proteins in neurons with….
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Excited for former postdoc Magda Kalinowska, whose work was published online today! With help from @fran_longo17 & @Mauricio_Neuro, she found that deleting Fmr1 in PV neurons alters translation and causes selective ASD-related behaviors. #fragileXsyndrome.
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RT @NYU_CNS: We are excited to announce that Dr. Anders Nelson (@andersmnelson) will join the Center for Neural Science at NYU, with his la….
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