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Jonathan Repple Profile
Jonathan Repple

@JonathanRepple

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Professor for Predictive Psychiatry Frankfurt, Germany. Interested in Affective Disorders, Neuroscience, Networks, CBASP Psychotherapy, Neurostimulation

Frankfurt am Main, Germany
Joined April 2013
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@JonathanRepple
Jonathan Repple
10 months
📣Highlights in Network Science and Mental Disorders! I’ve been fascinated by the application of network analysis in mental disorder research, particularly in exploring brain connectivity networks and symptom networks.
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@JonathanRepple
Jonathan Repple
2 months
Looking for a 3-year 100% postdoc position at the intersection of mental health, neuroimaging and biological markers? Come join our team:
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@KemtrupTweets
Kemtrup
9 months
An important point that the anti-psych folks like Moncrieff get wrong. There isn’t some straightforward, easy to draw distinction between masking a feeling, being distracted from a feeling, reducing the feeling, gaining more autonomous control and capacity for insight despite
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@JonathanRepple
Jonathan Repple
10 months
I probably missed a lot. What were your favorite ones?
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@JonathanRepple
Jonathan Repple
10 months
And finally, @LeaSchumacher20, Elisabeth Schramm, Levente Kriston and others showed in World Psychiatry that person-specific symptom networks strongly improved the accuracy of the prediction of psychotherapy response:
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onlinelibrary.wiley.com
Psychotherapies are efficacious in the treatment of depression, albeit only with a moderate effect size. It is hoped that personalization of treatment can lead to better outcomes. The network theory...
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@JonathanRepple
Jonathan Repple
10 months
Employing data from @enigmabrains, Foivos Georgiadis, @MMG_Kirschner and many others showed that the heterogeneous pattern of cortical alterations can be traced back to common brain circuits:
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nature.com
Molecular Psychiatry - Connectome architecture shapes large-scale cortical alterations in schizophrenia: a worldwide ENIGMA study
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@JonathanRepple
Jonathan Repple
10 months
Back to brains, a study by @miklosargyelan, @ZhiDeDeng, Chris Abbott and many others from the @BergenGEMRIC showed that changes in causal depression networks after electroconvulsive therapy relate to treatment outcome in MDD patients. This was published in Molecular Psychiatry:
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@JonathanRepple
Jonathan Repple
10 months
For an overview of symptom network analysis, please read this great piece by @giovbriganti @BorsboomDenny @EikoFried Tessa Blanken, Richard McNally and others published in the International Journal of Methods in Psychiatric Research: https://t.co/PmAoGQ3H2X
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onlinelibrary.wiley.com
Network approaches to psychopathology have become increasingly common in mental health research, with many theoretical and methodological developments quickly gaining traction. This article illustr...
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@JonathanRepple
Jonathan Repple
10 months
Back to symptom networks, Omar Ebrahimi, @BorsboomDenny, @And_Cipriani and colleagues demonstrated most MDD patients within the same depressive symptom severity group displayed differential symptom dynamics. This was published in the British Journal of Psychiatry:
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@JonathanRepple
Jonathan Repple
10 months
In line, a new approach to study the extent of involved regions in functional brain networks based on repeated measurements showed marked differences in salience network regions in MDD. This work by Charles Lynch, Conor Lyston and others was published in Nature Medicine:
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@JonathanRepple
Jonathan Repple
10 months
Next, a study on different brain subnetworks by @LeonardoTozzi1 @LMWilliams_PhD and colleagues on brain subnetworks that relate to different symptom dimensions and treatment outcomes in major depressive disorder (MDD) published in Nature Medicine:
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nature.com
Nature Medicine - Personalized brain circuit measures quantified using a new imaging technology in 801 patients with depression and anxiety identify six biotypes with unique symptoms, behaviors and...
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@JonathanRepple
Jonathan Repple
10 months
First, a two-part review on the theory and application of A Dynamical Systems View of Psychiatric Disorders written by Marten Scheffer, Barnaby Nelson, @clbockting, @BorsboomDenny and others in JAMA Psychiatry:
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@JonathanRepple
Jonathan Repple
10 months
With that in mind, I wanted to share some of the most exciting papers I read in 2024 that explore brain or symptom networks in some capacity.
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@JonathanRepple
Jonathan Repple
10 months
Currently, we’re part of a large consortium called DYNAMIC https://t.co/RtdsD3eKfd focuses on leveraging changes in dynamic network properties across these levels to improve our understanding and treatment of mental disorders.
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@JonathanRepple
Jonathan Repple
10 months
Great international speakers here in Frankfurt
@ecnptweets
ECNP
10 months
The #ECNP Roadmap Meeting 2025 has just started! ECNP President @MartienKas opens the meeting with an introduction to the #PrecisionPsychiatry Roadmap Initiative. A warm welcome to all participants joining virtually and in-person in Frankfurt, Germany! #Neuroscience #Psychiatry
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@JonathanRepple
Jonathan Repple
10 months
This is exactly how you push back against biased articles based on outside opinions (!) in psychiatry. Great job, again, @awaisaftab. This is a must-read not only for journalists in UK, but everyone interested in the debate worldwide:
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psychiatrymargins.com
British journalists and editors, this is for you
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