Could tolerance to DNA be broken in the gut in systemic lupus erythematosus?. In our latest review we explore whether tolerance to DNA can be broken when undigested DNA from microbiota in GALT directly encounters B cells unrestricted by T cell dependence.

RT @JExpMed: Immature B cell homing shapes human lymphoid tissue structure and function. A new Perspective by Jo Spencer & Chiara Dionisi @….

RT @JExpMed: After leaving the bone marrow, transitional B cells split into subsets w/ biased expression of homing receptors and different….

Our latest perspective piece is out now in @JExpMed! Here we propose that recruitment of immature B cells could contribute to human lymphoid tissue structure and function.

Lots of amazing work on display at Spatial Biology Research @ King’s symposium, a pleasure for our postdoc @michaeljpitcher to showcase our work with the Spatial Biology Facility, using @nanostringtech CosMX to study B cells in gut lymphoid tissue. @KCLcancer_pharm @JelmarQuist

RT @JoSpencerLab: Our latest paper is out now in @NatureComms! . Lucia Montorsi and @michaeljpitcher from our lab and collaborators identif….

RT @CellPressNews: Gut-associated lymphoid tissue: a microbiota-driven hub of B cell immunity. Check out this review by @BemarkMats & @josp….

*Link corrected*.

Huge thanks to our collaborators including @gibbonslab @fcicca @KCLImmunoMicro @KingsCollegeLon @GSTTresearch @BemarkMats and others.

Normal functions of DN2 B cells, DNASE1L3 and C1q in the gut likely relate to bacterial recognition, bacterial killing and disposal of bacterial debris including DNA. Failure of this system could result in persistence of bacterial DNA that could stimulate an autoimmune response.

By a combination of spatial transcriptomics and multiplexed single-cell technologies, DN2 B cells (previously known to be expanded in blood in lupus) were found to interact in GALT with dendritic cells co-expressing lupus autoantigens DNASE1L3 and C1q, adjacent to bacteria.

Our latest paper is out now in @NatureComms! . Lucia Montorsi and @michaeljpitcher from our lab and collaborators identified characteristics of autoimmune diseases as normal components of the immune system in human gut:.

Big thanks to all our collaborators including @gibbonslab @BemarkMats @fcicca @GSTTresearch @gsttnhs @KCLImmunoMicro @KingsCollegeLon and others.

Normal functions of DN2 B cells, DNASE1L3 and C1q in the gut likely relate to bacterial recognition, bacterial killing and disposal of bacterial debris including DNA. Failure of this system could result in persistence of bacterial DNA that could stimulate an autoimmune response.

By a combination of spatial transcriptomics and multiplexed single-cell technologies, DN2 B cells (previously known to be expanded in blood in lupus) were found to interact in GALT with dendritic cells co-expressing lupus autoantigens DNASE1L3 and C1q, adjacent to bacteria.

RT @TrendsImmuno: Gut-associated lymphoid tissue: a microbiota-driven hub of B cell immunity #immunology https://t.….

RT @BemarkMats: Our review for Trends on the current knowledge of GALT is now out. We discuss its organisation, the role of GALT in B cell….

Our review of the current knowledge of GALT is out now in @TrendsImmuno ! In collab with @BemarkMats, we discuss GALT organisation, B/T cell interactions, responses to microbiota, and links between GALT and autoimmunity

RT @Inst_of_Hep: Thank you so much Prof Jo Spencer @JoSpencerLab for a fascinating exploration of how #imc #imaging #masscytometry in tissu….

RT @gibbonslab: Delighted to say our latest paper has just come out .Huge thanks to all those involved