Jeff Freiberg, MD, PhD
@JeffFreiberg
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ID physician scientist studying S. aureus and antibiotic failure. Here mostly for the ID. Views my own.
Joined April 2020
🆕💫(STOP-Vanc) RCT protocol @VUMC_ID @JeffFreiberg Swab Testing to Optimize Pneumonia treatment with empiric Vancomycin The study will provide the 1st RCT data regarding the use of MRSA nasal swab PCR testing to guide antibiotic de-escalation #idxposts
https://t.co/HZu0M5RzhF
trialsjournal.biomedcentral.com
Background Vancomycin, an antibiotic with activity against methicillin-resistant Staphylococcus aureus (MRSA), is frequently included in empiric treatment for community-acquired pneumonia (CAP)...
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The study protocol for STOP-Vanc, our RCT looking at the use of MRSA nares PCR testing in an ICU, is finally published! We are hoping to be done with enrollment soon and excited to see what we learn from this study! @VUMCLHS
https://t.co/gcxO5ncaI6
trialsjournal.biomedcentral.com
Background Vancomycin, an antibiotic with activity against methicillin-resistant Staphylococcus aureus (MRSA), is frequently included in empiric treatment for community-acquired pneumonia (CAP)...
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Free scientific illustrations for biologists! 😍 @NIH has released a library of 500+ free scientific illustrations to create figures, presentations, and illustrations! all freely available in the public domain. Retweet and spread the message! https://t.co/p1bD1kxO7H
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I am excited to announce that my work on antibiotic treatment failure in Staph is now funded through a K08 from @NIAIDNews! A big thank you to @VUMC_ID @VUMC_MedPSTP @EFSInsideScoop and especially my mentor @EricSkaar to help get me to this point!
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We have an open #TID fellowship position @VUMC_IDFellows. @VUMCTransplant is a high-volume transplant center ( lung, heart, kidney, pancreas, liver) with a diverse patient population and pathology. The program has expanded to 6 faculty members and APRN.
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I appreciate the work that went into this study, but if your prediction, absent a new mechanism or major change, looks like this, I’m worried your conclusions follow from assumptions and not evidence
🆕 Antimicrobial resistance poses an important global health challenge in the 21st century. A new in-depth global analysis suggests more than 39 million deaths from antibiotic-resistant infections could occur between now & 2050. Explore the data: https://t.co/MWXNRrUDuz
#AMR
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🚨My favorite event of the year is here 🚨 - the @VI4Research DEI Symposium is highlighting Immigrant scientists (so timely, huh?)!! Talks from @mraffatellu , Sophie Helaine and Yi-Wei Chang. Open to VU/VUMC community! Link to register: https://t.co/uA155Y4OId - Please, RT!
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📢📢📢📢📢 Calling all ID educators and learners: Check out the newly published #IDChalkTalks from the @IDSAMedEdCOP following peer review. https://t.co/eVwfb4HsT5 These are open-access and available for teaching or learning ID content 1/
idsame.notion.site
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Honored to have our recent paper included as a @NatureComms Microbiology and Infectious Diseases Editor’s Highlight! Thanks for featuring our work on antibiotic tolerance in S. aureus! @EricSkaar @VUMC_ID @VUMCPathology @VI4Research
https://t.co/I6FqW6FbKB
nature.com
This page highlights recent articles on all aspects of bacteriology, mycology, parasitology and virology, covering the biology of pathogens, host-pathogen ...
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Get out of the lab and join the 2024 International Conference on Gram Positive Pathogens! Hosted by @UNMC_PathMicro Center for Staphylococcal Research (CSR). Early registration is ending on August 24. 📅 October 13-16, 2024 🏙️ Omaha, NE ✍️Register at https://t.co/iSMoEFekuh
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New publication from @EricSkaar Lab including confocal microscopy from the @zeiss_micro LSM880. 3D imaging shows complexity of extracellular matrix of biofilms. Thanks for using and acknowledging the CISR!
Antibiotic tolerance in Staph aureus biofilms is induced by arginine depletion by @JeffFreiberg in @NatureComms opens up possible new ways to treat challenging Staph infections 🦠 💉 💊
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Surreal I get to present with these inspiring women! Can’t wait to interact with you all. Thanks to @scrippsresearch for the invitation.
Join our virtual immunology symposium @scrippsresearch on Wed, Sept 18 featuring @zurisullivan, @alexwellsies, @DjenetBousbaine, @ValeriaMReyes, @CicaCanesso, Dr. Delconte, @Liwen_Deng811, & @NZanluqui. Register: https://t.co/YQ9eegfgjJ
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I am grateful for all the mentoring I received from @EricSkaar throughout this project & for all the members of the Skaar lab & @CassatLab who helped with this work. I also want to thank @VUMC_ID for the opportunity to continue my work to find solutions for abx txt failure
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Incredibly proud to share the latest publication to result from my research furthering our understanding of why antibiotics fail, now out in @NatureComms! The surprise contributor to antibiotic tolerance in S. aureus? Arginine metabolism!
nature.com
Nature Communications - Utilising proteomic and transposon sequencing screens, Freiberg et al. identified arginine metabolism enzymes that impact tolerance to antibiotics in Staphylococcus aureus,...
Antibiotic tolerance in Staph aureus biofilms is induced by arginine depletion by @JeffFreiberg in @NatureComms opens up possible new ways to treat challenging Staph infections 🦠 💉 💊
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Imaging of gangliosides during Staph infections. New paper from Katerina Djambazova and the @SpragginsLab. Happy to be involved in this beautiful work. @J_ASMS 🔬 🦠
pubs.acs.org
Gangliosides play important roles in innate and adaptive immunity. The high degree of structural heterogeneity results in significant variability in ganglioside expression patterns and greatly...
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Transplant ID Fellowship #TxID at Vanderbilt @VUMCTransplant is accepting applications for 1-year fellowship (2025-2026). Learn from our growing section of 6 faculty in 🎵City! @TxID_Fellows @ID_fellows @AST_IDCOP @maricar_malinis @VUMC_ID
https://t.co/dVgVcubydP
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Thrilled to be @IDSAMedEdCOP’s featured educator for July for my work in founding @TxID_Fellows. Thanks to @TMcCarty2010 for nominating me! And be sure to follow @TxID_Fellows for #TxIDChat events and other #TxID content 🤓
Congrats to @GorslineChelsea on being selected as this month’s #featurededucator @IDSAMedEdCOP. SO SO SO well-deserved https://t.co/dVrUFwYm66
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Congrats to @GorslineChelsea on being selected as this month’s #featurededucator @IDSAMedEdCOP. SO SO SO well-deserved https://t.co/dVrUFwYm66
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Broad spectrum antibiotics are the refuge of the poor diagnostician!
This is why only true experts should be allowed to make these decisions. So they aren't driven by irrational panic. And are instead driven by cold, hard facts. What bugs, cause what infxns, resistant to what abx? Start with that. Then you move to, ok, what abx cover those bugs.
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