José David Jarmell
@JarmellJose
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“It is the first responsibility of every citizen to question authority.” - Benjamin Franklin
Joined January 2020
1. La placa de la V16. Antena, moden y diversos Chips. Uno de ellos es una controladora. Han descubierto que la Baliza ya esta en alimentación tan pronto se le colocan las pilas. El pulsador solo activa las Luces LED. Si señores, es un rastreador de seguimiento en toda regla.
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This is me speaking personally as a patient. I know people are cautious about believing in new projects and I share that caution. BC007, efgartigimod, ampligen and others all fell through and I had hope in each of them, so I fully understand the hesitation. But I do want to
@scott_scientist @RenegadeRes Completely agree and understand. I was in the same loop when I first got ill. Expected so many projects to succeed and then nothing came from it 5 years later, can only imagine what it is like for those who have seen decades of this. We will continue pushing forward until our
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If you are in any Long COVID or ME groups, please feel free to share. We’re looking to get this moving as fast as possible.
Excited to share. We are offering 20 funded spots for the @amaticahealth 31 marker protein panel to adolescents (under 18 years of age) UK residents mainly, but global can apply in case we don’t reach 20 UK Apply here: https://t.co/YwzQ7ZSj5o Please share everywhere for reach!
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This is why our @amaticahealth RNA sequencing test will be so powerful. ~ 2500 altered markers in women ~ 1500 altered markers in men Astronomical more insight compared to started tests that show no differences.
RNA-seq - strong separation of patients vs controls and by sex. Females had 1,088 genes up and 1,522 down vs female controls. Males had 662 up and 749 down vs male controls.
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Excited for the end of 2025 and upcoming 2026. 2025 proved the concept - we’ve shown biomarker subgroups that match symptom patterns. markers vs tinnitus, markers vs PEM, etc. Now it’s time to scale and start truly solving this disease. Follow along @amaticahealth
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New from Ron Davis team: Virus Genome Sequences in the Blood of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients https://t.co/z3AkNJomLN "Surprisingly, more viruses were found in the healthy controls than in the ME/CFS patients" #MEcfs #CFS
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I get many DMs asking if I think there’s hope for severe ME & LC patients Short answer: yes Long: I’ve seen many severe patients become mild in hours after finding the right treatment. I believe precision medicine will help identify that for each person and that era is coming
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You truly don’t understand how sick a human can be until you’ve seen an ME/CFS patient. Nothing compares.
“Most of the people I’ve seen with #MECFS are so much sicker than my cancer patients.” Dr. Fridbjörn Sigurdsson, a former medical oncologist now focused on ME/CFS, speaking at the 2025 @Invest_in_me conference. Thanks to @mecfsskeptic for finding the clip.
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“Most of the people I’ve seen with #MECFS are so much sicker than my cancer patients.” Dr. Fridbjörn Sigurdsson, a former medical oncologist now focused on ME/CFS, speaking at the 2025 @Invest_in_me conference. Thanks to @mecfsskeptic for finding the clip.
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These two images show the importance of subgroup analysis. Combined you may assume no difference against control. But when you seperate by severity potential findings exist. Overlap with control doesn’t negate meaning. Even a 10-20% reduction/increase of interval proteins can
New exploratory @amaticahealth data: Reduced DRP1 protein in mild patients, shifting to raised in severe and very severe patients with ME/CFS and Long COVID. DRP1 regulates mitochondrial fragmentation - this may reflect changes in mitochondrial health across severity.
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Elevated HIF1a in Severe/Very Severe ME/CFS & Long COVID patients compared to mild/moderate patients.
Thank you to all our patients who submitted form data Comparing Mild/Moderate vs Severe/Very Severe patients, we found elevated HIF-1α in more severe Long COVID + ME/CFS This could reflect a combination of worse tissue hypoxia, mitochondrial dysfunction or a metabolic shift
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Super interesting finding. BH2 & BH4 both reduced during PEM for ME/LC patient. As a disease no major difference were seen against control, but this PEM finding could indicate a wider PEM specific mechanism that isn’t seen during rest.
PEM series preview BH2 + BH4 decreased after PEM in our patient These cofactors are crucial for neurotransmitter synthesis and blood vessel dilation Depletion suggests oxidative stress overwhelms the system, possibly contributing to vascular, cognitive, and immune dysfunction
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ACE reduction in patient POST PEM triggering
Coming soon we have a series on our first PEM findings. Below: one patient's ACE levels before and after PEM Despite being for many patients the single symptom that prevents them from returning to life, PEM is not well understood. Our goal is to add much needed resolution
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🔬We looked at HPA axis gene levels - a neuroendocrine system that regulates the body's stress response We found 4 ME/CFS & Long COVID subgroups showing different patterns of stress signaling, brain chemistry, & inflammation-related activity (Preliminary @amaticahealth results)
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Ok, I looked into this because sometimes claims that "China invents Y" can be somewhat exaggerated. But this is real, and completely insane. This technology called "Bone 02" (inspired by the well-known "502 glue" in China) has been developed for the past 9 years by a team of
researchgate.net
Xianfeng Lin is an Orthopedic surgeon and currently working in the SIR RUN RUN SHAW hospital affiliated to Zhejiang university school of medicine. Dr. Lin is mainly engaged in the application and...
🚨🇨🇳 BREAKING: CHINA has invented a new 'BONE GLUE' that repairs bone fractures in just 3 minutes — no surgery or metal plates needed
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RNA drugs are super interesting. Unlike standard drugs that only try to mimic or prevent protein effects, often only accounting for a portion of their effects, RNA therapies can restore proteins or reduce harmful ones. AMT-130 for Huntington’s lowers huntingtin.
🚨 The first disease-modifying therapy for Huntington's disease was just announced this morning. 75% reduction in symptoms over 36 months. This isn't hype. It's field-changing. And it uses RNA. Here's what you need to know about $QURE AMT-130 🧵
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🚨 The first disease-modifying therapy for Huntington's disease was just announced this morning. 75% reduction in symptoms over 36 months. This isn't hype. It's field-changing. And it uses RNA. Here's what you need to know about $QURE AMT-130 🧵
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If you are able to and interested in funding research into ME/CFS, Long COVID, Lyme, MCAS, and alike diseases - we want to talk. Please send me a DM or email (team@amaticahealth.com) Funding strategically used with a high research/£ ratio is integral to solving this disease.
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Received more results today for batch 2 31 marker and already some very close to significant findings (p = 0.067). Which has grown in strength on the trend from the previous results and may grow further with batch 3. Lots of results in the next month!
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1) Interesting presentation by Dr. David Fajgenbaum. He suffered from a rare and life-threatening inflammatory disorder (Castleman disease) and found a FDA-approved drug (Rapamycin) that helped him go into remission. He's now looking to repurpose drugs for other diseases.
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