Jacobs Lab
@JacobsLabUCLA
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Lab of Dr. Jonathan P. Jacobs | #UCLAGI @dgsomucla | Translational approach to study the role of the intestinal microbiome in human disease | Microbiome Core
Los Angeles, CA
Joined June 2023
@JulianneCYang Many thanks also to the UCLA Microbiome Core, Goodman-Luskin Microbiome Center, UCLA Technology Center for Genomics & Bioinformatics, and the National Gnotobiotic Rodent Resource Center at UNC! Proud to be @UCLAGIHep @dgsomucla !
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Many thanks to @JulianneCYang and co-authors for the hard work that went into this study!
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This study highlights the importance of selecting relevant intestinal regions for studies of diseases with region-specific dysbiosis, and the results warrant further investigation into alternative approaches to fecal microbiota transplantation in microbiome studies.
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Region specific patterns in bacterial composition and function were perturbed or partially recapitulated in germ-free mice colonized with mouse or human feces (a tool commonly used to infer microbiome causality)
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Various aspects of bacterial metabolism were also generally SI enriched, including simple carbohydrate degradation, lipid fermentation, and cross-feeding, while butyrate production was colon-enriched.
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In line with previous reports, small intestine (SI) - enriched bacteria were largely aerotolerant or facultative anaerobes, while colon- enriched bacteria were obligate anaerobes. Surprisingly, the genus Akkermansia was enriched in the SI lumen relative to the colon lumen.
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Leveraging luminal and mucosal samples meticulously collected and sequenced from the duodenum, jejunum, ileum, proximal colon, and distal colon, we highlight region - specific bacteria and metabolic functions robust across 3 cohorts of SPF mice.
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Excited to share our new work in @ISMEJournal exploring the biogeography of the gut microbiome in SPF and germ-free mice colonized with mouse or human feces (a common tool for inferring microbiome causality). https://t.co/2pU9tqeQmZ
academic.oup.com
Abstract. Fecal microbiota transplantation has been vital for establishing whether host phenotypes can be conferred through the microbiome. However, whethe
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In @Gut_BMJ, a study supports that microbiota "dysbiosis exists as a pre-disease state detectable by faecal and serum biomarkers for #IBD risk prediction." @JacobsLabUCLA @pedsIBDdoc @grahambiota @JoanaTo62523004 @JeanFredericCo1 @jeremiahfaith1
#Microbiota👇
#GUTImage from the paper by Jacobs et al entitled "Age-related patterns of microbial dysbiosis in multiplex inflammatory bowel disease families" via https://t.co/8UdzLRBZa4
#IBD
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Dr. Jesús A. Araujo & @JacobsLabUCLA 🔖in @IJMS_MDPI - Ambient Particulate Matter Induces In Vitro Toxicity to Intestinal Epithelial Cells without Exacerbating Acute Colitis Induced by Dextran Sodium Sulfate or 2,4,6 Trinitrobenzenesulfonic Acid 👉
mdpi.com
Inflammatory bowel disease (IBD) is an immunologically complex disorder involving genetic, microbial, and environmental risk factors. Its global burden has continued to rise since industrialization,...
Dr. Jesús Araujo and Dr. Jonathan Jacobs’ new study investigates air pollution’s impact on colitis and cardiovascular health. While pollution doesn’t exacerbate colitis in their models, it may influence cardiovascular risk through gut bacteria. Read more: https://t.co/sYkQu8J4NS
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Dr. Elaine Hsiao (@pipethero) named among the🌎most influential researchers in sciences & social sciences for 2023 by @Clarivate. Authored studies rank in top 1% in number of scholarly citations worldwide! #UCLAMicrobiome 👉Full @UCLA faculty list https://t.co/krJCWTBGbF
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Microbiota-Dependent Upregulation of Bitter Taste Receptor Subtypes in the Mouse Large Intestine in High-Fat Diet-Induced Obesity 🔖@Nutrients_MDPI 🖊️F Caremoli J Huynh V Lagishetty D Markovic Jonathan Braun @TienDongMD @JacobsLabUCLA Catia Sternini 👉 https://t.co/AO0rt4Hwct
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A Video Byte describing the lab's recently published IBS multi-omics study is now posted on Research Square. Check out the video: https://t.co/OI4u0y7fW4 Read the initial paper: https://t.co/ILP7od1yDD
#microbiome #IBD #ibs
researchsquare.com
Irritable bowel syndrome (IBS) is a common and painful gastrointestinal disorder that is difficult to treat. IBS pathogenesis likely involves the gut microbiome, but no consistent changes have yet...
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🙌@DanRWangMD (@uclaCVfellows) receives #UCLAMicrobiome Seed Fellowship Award! 🔹Racial/ethnic disparities in cardiovascular risk amidst discrimination: A lipidomics, gut #microbiome & neuro-imaging analysis 🔹Mentors: @AGuptaCNS @TienDongMD @GilbertGee6
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🏆Naomi Gancz (@NGancz) & Fran Querdasi (@fquerdasi) receive #UCLAMicrobiome Seed Fellowship Award! 🔹Early adversity and internalizing in middle childhood to adolescence: Gut #microbiome and inflammatory mechanisms 🔹Mentor: @Dr_BCallaghan (@UCLAPsychology @BABLab_UCLA)
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Ruth, our summer intern and a participant in the Bioscience Scholars Program, presented her research on brain activation in mice colonized with microbiota from IBD patients today! We are proud of her! #research #trainee #earlyincareer #ibdresearch #microbiome
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