Jurgen Claassen
@J_C_MD_PhD
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Geriatrician, scientist, Radboudumc, Alzheimer,Hypertension-Brainbloodflow, Donders Institute. Author ‘Wat kun je doen aan dementie?’
Netherlands
Joined December 2010
“My sister was killed by my ‘nurse’ mum’s twisted conspiracy theories: nobody else should go through this”
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RT @_JCBFM: Congrats for your paper and thanks for choosing.@_JCBFM!. #StrokeResearch #Neuroscience #Ischemia #Neuroprotection #DrugDiscove….
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RT @TokyoTom2020: 📌I saw a Japanese commentator this morning—a learned scholar specializing in American government and politics—who noted t….
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RT @ProfRobHoward: This. Blood-based biomarkers for Alzheimer's disease should only be used in the context of a specialist dementia diagnos….
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Interesting study; I’m mostly intrigued by the 10% of centenarians who have no AD pathology, and by the 5 centenarians with high amyloid load yet normal cognition.
Amyloid-beta accumulation in centenarians is associated with reduced cognitive performance and is not a benign aspect of aging.
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‘As I get older I want to be seen in terms of doors that might still open for me, not ones that have already closed.’.This is something I hope I’m doing in my outpatient clinic. For example in patients with dementia: ‘focus on what you can stil do well’.
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RT @SageJournals: Don’t miss the new @_JCBFM editor’s choice collection! Browse articles on blood transit time, cerebral perfusion, and hem….
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RT @Pat_Brassard: Here is the latest work from @LawrenceLabrecq (PhD paper #4) related to cerebral pressure-flow relationship directional s….
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Useful diagnostic imaging tips for acute onset neurological symptoms suggestive of autoimmune encephalitis:T1-Weighted Spin Echo Sequence and Encephalitis
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RT @physiolrev: #OpenAccess: Review from @physiolrev, Biomarkers of #aging: from molecules and surrogates to physiology and function. @regu….
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Dame Judi Dench Backs Call For Government Action On Dementia Diagnosis
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RT @westernuFHS: New 📄 collaboration with @smpeters9, @LbhhNvrl in @_JCBFM: ‘Dynamic cerebral autoregulation in people with mild cognitive….
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Malnutrition in Older Adults | New England Journal of Medicine
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Nice to see more indirect research on #cerebral #autoregulation confirming our experimental findings that autoregulation is preserved in many circumstances.
Diffusion-weighted imaging lesion frequency and volume were unaffected by intensive antihypertensive therapy in patients with sub-acute intracerebral hemorrhage.
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This research challenges several widespread assumptions about treating #hypertension in #frail older people… I am now convinced we have under treated rather than over treated older people. Time for a paradigm shift! #geriatrics.
🆕 Open🔓 Access Article.Intensive antihypertensive treatment does not lower cerebral blood flow or cause orthostatic hypotension in frail older adults by Ralf W. J. Weijs & Jurgen A. H. R. Claassen (@J_C_MD_PhD) et al. #frailty #geriatrics #longevity
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It took the dementia field a while but they are finally accepting the vascular hypothesis of dementia, including #Alzheimer. I still remember the ‘no you stupid, Alzheimer’s is amyloid, or has nothing to do with vascular disease ’ responses to my papers 15 years ago 😀.
Most viewed this week from @JAMANeuro: . Between 22% and 44% of dementia cases by age 80 are attributed to midlife and late-life vascular risk factors, according to this cohort study.
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#memoryclinic #diagnosis Biomarker-Driven Diagnosis in Neurocognitive Disorders | Neurology Clinical Practice
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