Joachim Wittbrodt
@JWittbr
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Joined February 2016
At #GfE2022, Kaisa Pakari @kaisa_pakari from @WittbrodtLab @_ThomThum_ presents recently developed genome editing wizardry, enabling her to engineer #medaka mutants of human diseases that would be out of reach for regular #CRISPR approaches. Check out https://t.co/rFITWAkEcI
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@kaisa_pakari shows how to modulate PMM2 (activity) levels on the protein or genetic level. Using Base editing with a trick broadens the targeting range when baseeditors are used sequentially https://t.co/U9foGqruAW
#medaka #baseediting #GfE2022 #glycosylation
biorxiv.org
Base editing by CRISPR crucially depends on the presence of a PAM in proper distance to the editing-site. Here we present and validate an efficient one-shot approach termed “inception”, relaxing...
Let's switch gears and look at glycosylation diseases, with Kaisa Pakari and medaka fish.
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If you happen to be at #GfE2022 in @UniHohenheim visit Bettina (@WelzBettina) at her poster Number 7 to learn about why our hearts beat so differently. #medaka @GfEeV #CRISPR
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The fish lateral line is a nice example of life-long growth of a mechanosensory system. At #GfE2022, Karen Groß from Lazaro Centanin's lab (#COSHeidelberg) highlights mechanisms involved in sprouting new neuromast organs in #medaka. Background at https://t.co/3F0Ag80I4I
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Interested in #RareDiseases? join @_ThomThum_ & @WittbrodtLab for #PhDposition We investigate Congenital Disorders of Glycosylation #CDG in translational #medaka fish models mutated based on the genetics of CDG-patients more details https://t.co/5vDuly1AdR please apply or RT!
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Our last work is now published in Science Advances. Using #medaka_fish and computational modelling, we shows how signals from the #thymus and localisation of #thymocytes influence the lineage outcome, please click https://t.co/ekih5sxcte
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Wie werden unsere körpereigenen, krebs- und virenabwehrenden T-Zellen gebildet? ForscherInnen des Uniklinikums Tübingen, der Universität Heidelberg und des EMBL haben neue Erkenntnisse über diesen Prozess gewonnen: https://t.co/8kVZmFMn2g
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for the traceable loss-of-function approach in this paper, we used a "knock-out via targeted knock-in" strategy employing a splice acceptor-GFP linked to a very potent polyA/terminator sequence derived from the ocean pout's anti-freeze gene. #glow #CRISPR #knockout 🐟🥊 #medaka
I am very excited to share: “The new paper from @Wittbrodtlab showing how #medaka and #zebrafish pluripotent embryonic cells assemble into #retina #organoids is out in @eLife. Many thanks and congratulations to all people involved! https://t.co/A4FME3Wxig
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Fantastic news! 👇
Thanks to those who put forward my name, thanks to the selection committee and ERC Council for shortlisting me, and thanks to Commissioner @GabrielMariya for selecting me. I look forward to working for the research community in Europe!
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Angry white males stoked by Trump, Fox News, and social media write their lame manifestos, buy semi automatic weapons, and murder. When you speak of other human beings as “vermin” that “infest our country,” and allow easy access to guns, you get this.... https://t.co/kfC1Dwdhbi
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Die Universität Heidelberg hat sich mit ihrem Konzept der Comprehensive Research University – einer Volluniversität mit herausragender Forschungsstärke – im Wettbewerb um den Titel „Exzellenzuniversität“ durchgesetzt. https://t.co/1LzHNFOFEF
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We are celebrating that @UniHeidelberg was successful in the #Exzellenzstrategie ! Thank everyone involved for pushing our university forward!
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A cluster of poster prizes! Congratulations to Paula Gutierrez Perez, Katharina Lust, and Clara Becker! #GfEIsSDB19
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"A basic scientist is driven by curiosity and the desire to understand the mysteries of nature." This "is in contrast to applied and translational research, which is designed to solve specific problems, like treating a disease or creating a product."
"In reality, every new discovery reveals how far away we are from gaining a true understanding of how cells and organisms work. Basic research allows us to assemble the very first pieces of a massive puzzle." https://t.co/W8TAwpUdug
@irinakitop
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Efficient single-copy HDR by 5' modified long dsDNA donors
elifesciences.org
The 5' modification of the donor template facilitates highly efficient Crispr targeted homologous recombination and at the same time favors single copy integration.
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Cell-autonomous factor (sox2) reprograms Medaka retina Müller glia to become regeneration competent @WittbrodtLab
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