Sean Booth
@ImDrBooth
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Assistant Professor at University of Manitoba. he/him
Oxford, England
Joined September 2016
Excited to share our latest paper where we explore how bacteria use weaponry. We analyse >2500 E. coli genomes and find that bacteriocins are associated with virulence factors and antimicrobial resistance. @NatureComms
https://t.co/xv2z7B1bsr
nature.com
Nature Communications - Bacteria employ a range of competition systems that deliver toxins to inhibit competing strains. This study shows that these systems are particularly important for the...
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New paper alert! Complex interactions between Pseudomona aeruginosa and Staph aureus involved in tolerance to silver of Staph. @MicrobioSoc @ImDrBooth
microbiologyresearch.org
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(1/6) Really jazzed to have this out - my first @wellcometrust fellowship paper! https://t.co/uhA1c5Qv0M Can bacteria evolve resistance to competitors' T6SS weaponry? We find that the answer depends on **how many toxins** competitors are using. A thread:
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I am thrilled to start my lab @Helmholtz_HZI this fall. I will continue my research in Bacterial Infection Ecology.
Vier neue Nachwuchsgruppen am HZI! Im Spätsommer und Herbst nehmen Lina Herhaus, @martintjahn, @Milan_Gerovac & @ntorow mit ihren #MICROSTAR-Gruppen die Arbeit auf, um die Resilienzmechanismen von #Mikroben und Menschen zu untersuchen. Herzlich willkommen! https://t.co/E6PlB8kcFK
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1/ Thrilled to share my final PhD project out as a preprint! A simple regulatory network coordinates a bacterial stress response in space and time. https://t.co/WmQibPoWTw
biorxiv.org
Bacteria employ diverse gene regulatory networks to protect themselves from stressful environments. While transcriptomics and proteomics show that the expression of different genes can shift strongly...
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Fabulous work by my colleagues @ImDrBooth, @willpjsmith, Kevin Foster - Stick'em with the pointy end ... UNLESS ... ?!?! "The evolution of short- and long-range weapons for bacterial competition" https://t.co/cOrpeqFdXl
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New pre-print! My first research project with @saramitri is now live. Interactions underpin our understanding of ecosystems, but can change in hard-to-explain ways. Here, we show that many of these variations can be predicted from underlying mechanisms:
biorxiv.org
Ecological interactions, the impact of one organism on the growth and death of another, underpin our understanding of the long-term composition and the functional properties of communities. Interac...
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These cells then burst, releasing their attack and red-stained DNA, which accumulates over time, filling the biofilm.
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A gradient of antibiotics from top to bottom counterintuitively attracts cells of Pseudomonas aeruginosa to crawl upwards. The antibiotic triggers the production of their own return fire ‘tailocins’ in elongated and blue cells, to attack a perceived competitor.
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As bacteria attach to a surface to form a biofilm, many cells burst, releasing red-stained DNA, which is a key polymer in biofilms. In this microfluidic cell, nutrients and time flow from left to right.
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In time for Halloween... These bacterial cells are bursting, leaving their red-stained DNA behind. #BiofilmCreate #BiofilmAware @ukbiofilms
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In this colony biofilm, we can see the amounts of three different species (each in a different colour) changes as the biofilm develops (starting in the top left, spiralling around to the center).
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The interactions between different kinds of bacteria change the composition of biofilms over time. I made this piece to show the complexity of biofilm ecology. #BiofilmCreate #BiofilmAware @ukbiofilms
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Our manuscript on FAST is now out (with a few new results and analyses) at PLOS Computational Biology! It's been a joint effort with Mack Durham - co-author and mentor par excellence - to get this over the finishing line: https://t.co/t4ITgL1ZId
journals.plos.org
Author summary Much of what we know about bacterial behaviour comes from tracking solitary cells through space and time. For example, one can unpick the mechanisms that drive chemotaxis by quantify...
Our cell tracking software, FAST, is now publicly available! Watch our summary video below for a quick rundown of its design and capabilities: https://t.co/vVCPBg3Oyl
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Two years ago BioIcons was launched and the database has grown by almost 800 icons thanks to many scientists contributing illustrations ☺️ Now we're looking to grow more and need your feedback and support... 1/2
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Juneteenth in STEMM and the barriers to equitable science
cell.com
We are 52 Black scientists. Here, we establish the context of Juneteenth in STEMM and discuss the barriers Black scientists face, the struggles they endure, and the lack of recognition they receive....
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Please sign the latest @OurCommons petition calling for increased federal funding for graduate students and postdocs through scholarships, fellowships & grants. Thank you @liberal_party MP @iamIqraKhalid for sponsoring! Sign here & RT: https://t.co/q93nsdcJt6
#SupportOurScience
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REMINDER: Are you an undergraduate student interested in a virtual summer research experience in the biosciences? If so, check out NSURP 2023! Apply here: https://t.co/XcNgLjVsDE Applications close March 31st. #DiversityandInclusion #STEM
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#FirstGen Friends, tell me the unwritten rules/culture you weren't privy to when you first started college. I'm giving a talk on Saturday, and I want to make sure I haven't forgotten any! Undergrad seems like such a long time ago... @AcademicChatter
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