IkonenLab
@IkonenLab
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The Ikonen group is interested in the cell biology of cholesterol and related lipids and has developed tools to visualize their distribution and traffic.
Helsinki, Finland
Joined January 2019
RT @rollingmeow: šThrilled to share our most recent work on how the lipid environment finely regulates the Golgi V-ATPase. A big THANK YOUā¦.
biorxiv.org
Sac1 is a conserved phosphoinositide phosphatase, whose loss-of-function compromises cell and organism viability. Here, we employed acute auxin-inducible Sac1 degradation to identify its immediate...
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New paper from our lab on how boosting homozygous knock-in efficiency enables robust generation of human auxin-inducible degron cells, by @ShiqianLi1 et al. in @GenomeBiology š„³.
Excited to share that my last paper at Ikonen Lab @IkonenLab was finally published at Genome Biology. It is interesting journey and thank to the great supports from friends, collaborators and my supervisor Elina Ikonen. @MiesvdStoel @rollingmeow @RaivioTaneli @_YZlab.
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RT @ShiqianLi1: Happy to share our new work on human cell engineering with an improved version of auxin-inducible degron system. A great coā¦.
biorxiv.org
Auxin-inducible degron (AID) technology is powerful for chemogenetic control of proteolysis. However, generation of human cell lines to deplete endogenous proteins with AID remains challenging....
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RT @NatureComms: Scientist from @Rachid_Thiam and @IkonenLab report formation of supercooled liquid crystalline lipid droplets by that cholā¦.
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Out in @NatureComms our fine collaboration with @Rachid_Thiam and Ilpo Vattulainen on how cholesterol esters form supercooled lipid.droplets whose nucleation is facilitated by.triacylglycerols.
nature.com
Nature Communications - Dumesnil et al. report that cholesterol esters (CE), which only melt above body temperature, form supercooled liquid crystalline lipid droplets (LD). Triacylglycerols (TG)...
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RT @szkabel: Our work at the 21st International Conference on Systems Biology (ICSB). Intense days of exciting talks, ideas and inspiring dā¦.
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Out in @CR_AACR our study showing that in operable #PancreaticCancer, regions distant from malignant cells already display proteomic changes related to lipid metabolism that affect prognosis and may be pharmacologically targeted.
aacrjournals.org
In clinically operable pancreatic cancer, regions distant from malignant cells already display proteomic changes related to lipid transport and metabolism that affect prognosis and may be pharmacol...
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RT @HiLIFE_helsinki: The call for @HiLIFE_helsinki Tenure Track Assistant and Associate Professors is open for one more month. Save the datā¦.
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RT @tom_mcphagy: I'm very excited to share our new article on #mitophagy #lipids and #iron now out in @embojournal!! šš. Congratulations Maā¦.
embopress.org
image image Whether removal of defective mitochondria is cause or consequence of metabolic reprogramming in highly energyādemanding cells remains unclear. This study reports metabolic effects of...
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RT @Endo_Connect: We are looking for a highly motivated PhD student for our consortium to work on a project on intracellular transport andā¦.
linkedin.com
We are looking for a highly motivated PhD student for our consortium to work on a project on intracellular transport and metabolism of major membrane lipids at the University of Helsinki! To find...
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We are recruiting a Doctoral Researcher! Those of you who have a strong interest in cell biological approaches to study intracellular transport and metabolism of lipids are warmly encouraged to apply. @Endo_Connect @HelsinkiUniMed .
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RT @ViolaNahse: Are you curious about the function of DFCP1 in autophagy? Have a look at our latest preprint - we find that it is an ATPaseā¦.
biorxiv.org
Cellular homeostasis is governed by removal of damaged organelles and protein aggregates by selective autophagy mediated by cargo adaptors such as p62/SQSTM1. Autophagosomes can assemble in special...
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RT @VeijoS: Excited to share our collaborative effort on the role of seipin at ER-mitochondrial contact sites, now out in Cell Reports! httā¦.
cell.com
Combot etĀ al. demonstrate that seipin is enriched at ER-mitochondria contact sites and that seipin deficiency leads to defective mitochondrial calcium import accompanied by a reduction in ATP...
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RT @STEMMProgram: STEMM Retreat is happening: The first day has been full of scientific interactions in presentations, workshop, and posterā¦.
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RT @Endo_Connect: Very nice 2nd day of the @Endo_Connect kick-off meeting, great lectures of @JKlumperman and Kristiina @Ikonenlab, great oā¦.
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RT @AvantiLipids: Know what it feels like to be an Avanti Award Winner? Dr. Elina Ikonen does! Find out what winning the award means to herā¦.
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Elina Ikonen has received 2021 Avanti Polar Lipids/EBSA Award that recognizes the most important European scientific contributions in the understanding of biophysics of #lipids. @HelsinkiUniMed @STEMMProgram š„³š.
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RT @embojournal: ORP2 couples LDL-#cholesterol exchange between late and recycling #endosomes to FAK activation and cell motility - new resā¦.
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New release fresh from our lab revealing how ORP2 controls FAK activation and LDL-cholesterol plasma membrane delivery by promoting bidirectional cholesterol/PI(4,5)P2 exchange between late and recycling endosomes! @HelsinkiUniMed @STEMMProgram .
embopress.org
image image How LDLācholesterol is delivered from late endosomes to the plasma membrane and enhances cell motility is unknown. Here, this is found to depend on ORP2āmediated lipid exchange between...
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RT @rollingmeow: Delighted to share our mini review by Prof. Ikonen and me @IkonenLab on intracellular cholesterol flow between membranes.ā¦.
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