Isidore Rigoutsos
@IRigoutsos
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Director, Computational Medicine Center (@CompMedicineTJU), Sidney Kimmel Medical College, Thomas Jefferson University (Any opinions expressed here are my own)
Philadelphia, PA
Joined September 2015
Do you know where in the cell your favorite microRNA/isomiR, tRNA-derived fragment (tRF) or rRNA-derived fragment (rRF) hangs out? . The answer may surprise you. We discuss all of this in our latest preprint: #isomiRs #tRFs #rRFs #miRNA #tRNA #rRNA.
biorxiv.org
Background MicroRNAs (miRNAs) and their isoforms (isomiRs), tRNA-derived fragments (tRFs), and rRNA-derived fragments (rRFs) represent ~95% of all short RNAs found in cells. All three types modulate...
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We are hiring! Apply using the link below. I look forward to speaking with you.
Do you want to build tools that help scientists make sense of biomedical #data and are used daily by people worldwide? If this appeals to you and you are a #SoftwareDeveloper, join our team at @JeffersonUniv!. #recruiting #hiring #computationalmedicine.
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RT @CompMedicineTJU: Did you know that tRNA fragments contribute to the immune response pathway? Read all about our new findings.on how 5'….
cm.jefferson.edu
Our study unveils a novel tRNA-engaged pathway in the innate immune response and newly assigned the role of immune activators to 5′-tRNA halves.
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We just released #isoMiRmap profiles of all isomiRs in the @1000genomes project and the 33 cancers of @theNCI 's Cancer Genome Atlas project. Get the profiles at: #TCGA #1000Genomes #NCI #NIH #Jefferson #PrecisionMedicine #Computational Medicine Center.
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Want to look for #miRNA isoforms (#isomiRs) in your RNA data? Check out our #isoMiRmap tool: .Detects #SNP, flags ambiguous sequences, and is really fast. Codes at: . #Jefferson #PrecisionMedicine #ComputationalMedicineCenter
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#tRNA fragments rule! .I hope you enjoy our latest review on #tRFs as much as we did putting it together: . #tRFs #tRNA #Jefferson #PrecisionMedicine #HealthDisparities.
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In our latest paper, we linked #tRNAfragments to the #mitochondria to multiple #cancer types, to #introns, to specific gene #pathways and to several categories of #junkDNA. .
#tRNAfragments, the #mitochondrion, #cancer, #repeatelements (#junkDNA), and #disparities -- seemingly unrelated yet deeply connected as we show in our latest work: . Congratulations to the #computationalmedicine team at #Jefferson. Go #PrecisionMedicine!.
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ICYMI -- #BigData in #cancerresearch
On the blog - Jefferson Harnessing "Big Data" to Broaden Cancer Research:
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RT @CompMedicineTJU: Join us again on November 07 for this year's PurpleStride Philadelphia 2015 to benefit pancreatic cancer research http….
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#PrecisionMedicine questions that we will need to address before long: http://t.co/aEao2zS4b3.
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Behold the power of the isomiRs.
New CMC article: #isomiRs (which we showed before depend on #Population, #Race, #Gender) matter in #BreastCancer - http://t.co/2Hscimu64K.
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