Hiller Lab
@HillerLab
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Group of Prof Sebastian Hiller. Structural Biology Research Group @biozentrum @Unibasel. Unravelling Biomolecular Mechanisms. (run by students)
Basel, Switzerland
Joined March 2019
Great pictures!.
It was great meeting Sebastian Hiller after 18 years at the joint #APNMR-@NmrsIndia meeting at @IISERPune. We worked in the same lab for five years, sharing the same office space, HPK-G13. The first photo is from 06/2025, and the second is from 04/2005.
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RT @biozentrum: A Day Dedicated to Science: On June 12, the @biozentrum community gathered for its traditional symposium. Bringing together….
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Congratulations to @annaleder_ receiving the Shepherd price for her PhD work at today’s @biozentrum symposium @biozentrum_phds . Stay tuned for the official paper release in the coming weeks.
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Our data reveal that calcium doesn’t affect the cycle, but combined with ADP accumulation it creates off-pathway states that prolong the nucleotide-bound lifetimes. This changes Hsp70’s function extending client protein interaction times — a new layer of cellular regulation!.
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This versatile in-cyclo NMR platform is adaptable to study diverse ATP-driven molecular machines beyond Hsp70 — enabling precise dissection of functional cycles, allosteric regulation, and the effect of cofactors or co-chaperones at unprecedented resolution. #MolecularMachines.
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Applied to the Hsp70 BiP NBD, in-cyclo NMR reveals all 11 microscopic kinetic rates of ATP binding, hydrolysis & product release — showing ADP·Pi release, not ATP hydrolysis, is the rate-limiting step of the cycle duration. Stay tuned for more results on the full-length Hsp70.
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Introducing in-cyclo NMR, a new method led by @GuillaumeMas2 at @biozentrum (@NatureComms)! This method combines high-resolution NMR with ATP regeneration & phosphate removal to resolve kinetics & dynamics of molecular machines - all in one experiment!
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Tired of costly cloning software? Try IVA Prime: a free, game-changing tool for automated primer design in IVA cloning! Simplify complex cloning with one click, reduce errors, and save time. Visit collaboration with @JGarciaNafria.
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Check out our latest story on the cryoEM structure of the BAM holo insertase complex! Out in @ScienceAdvances (
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Big week ahead for our lab! @annaleder_ presents at the 1.2 GHz inauguration in Zurich, and @GuillaumeMas2 speaks at @ENC_Conf (5:05pm PT) in Asilomar #ENCISMAR2025. Expect groundbreaking ideas on enzymology, molecular chaperones, LLPS, & ER biology. Don’t miss it!.
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Happy to announce the release of our collaboration with the @JenalLab! @GuillaumeMas2 led the NMR analysis, identifying the toxin’s product and unravelling the enzymatic properties of the toxin-antitoxin system.
Researchers @JenalLab and @HillerLab have discovered how a dangerous human pathogen causing pneumonia uses a kind of molecular "sleeping pill" to enter a dormant state to persist antibiotic treatment. @UniBasel_en @NCCR_AntiResist @snsf_ch @EMBOPress
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RT @AHarms485: You are looking for a PostDoc position or know someone who is? We are looking for someone to join our team at @ETH_en Zürich….
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RT @AHarms485: Preprint alert 🚨! I present you the second and final manuscript on the BASEL phages! 36 new deeply characterized phages from….
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RT @IBS_Grenoble: Welcome to the 28 students and post-doctoral researchers from all over the world who are starting today the @EMBO Practic….
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RT @NCCR_AntiResist: We are delighted to announce we @NCCR_AntiResist are funding a four-year PhD position with the Boeck lab in Infection….
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RT @petrovic_iv: Honored to receive the J.C.W. Shepherd Prize for scientific excellence. Thanks to the BZ committee @biozentrum for select….
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It was nice applying #NMR_Spectroscopy on your de-novo designed β-barrels. We love β-barrels! :).
Our nanopore design paper is now published! We developed computational methods to design de novo pores with custom size, conductance and shape. We hope the technology will advance a range of sensing applications. @structbiolbxl @VIBLifeSciences @_VIB_AI
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