Sean Hennessy
@HennessySean
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Professor of Epidemiology; Director, Center for Pharmacoepidemiology Research and Training; Director, Division of Epidemiology, Univ of PA
Philadelphia
Joined May 2011
A new model developed by our group does surprisingly well at predicting stimulant-related overdose in Medicaid-insured persons. https://t.co/6mnHMTAJpN
ldi.upenn.edu
Overdose deaths involving stimulants, such as cocaine, methamphetamine, or ecstasy, have substantially increased in the U.S. since 2011.
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Great new paper in Clinical Pharmacology & Therapeutics led by doctoral student Haedi Thelen: Characterizing Treatment Effect Heterogeneity Using Real-World Data https://t.co/RyWp9mNAHv
@HaediThelen @HennessySean
ascpt.onlinelibrary.wiley.com
Characterizing heterogeneity of treatment effects (HTE) is a fundamental goal of pharmacoepidemiology, addressing why medications work differently across patient populations. This paper reviews...
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To meet popular demand, CIOMS will hold a 2ndwebinar to introduce its Working Group XIII report entitled Real-world data and real-world evidence in regulatory decision making.This will be held at 2 pm CET on 23 January.
cioms.ch
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Newly published in Clinical Pharmacology and Therapeutics and featuring several CREST investigators: Risk of Hypoglycemia Associated with Concomitant Use of Insulin Secretagogues and ACE Inhibitors in Adults with Type 2 Diabetes: A Systematic Review https://t.co/XtUCZD6e93
ascpt.onlinelibrary.wiley.com
Insulin secretagogues and angiotensin-converting enzyme inhibitors (ACEIs) are commonly co-prescribed for patients with type 2 diabetes (T2D). Case reports suggesting that co-administration of...
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Check out the latest from the CREST team in Clinical Pharmacology & Therapeutics ⬇️ Concomitant Use of Oral Anticoagulants with Oral Dipeptidyl Peptidase-4 Inhibitors and Serious Bleeding Events @phuongpng @HennessySean @CE_Leonard @Miano81
https://t.co/sTjXyA6TU2
ascpt.onlinelibrary.wiley.com
In a prior screening study, saxagliptin, a dipeptidyl peptidase-4 inhibitor (DPP-4i), was found to have an increased rate of serious bleeding when used concomitantly with several oral anticoagulants...
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Newly published in Clinical Pharmacology & Therapeutics ⬇️ Risk of Opioid Overdose Associated with Concomitant Use of Methadone and Statins @Alicechencheng @Miano81 @CE_Leonard @HennessySean
https://t.co/vDO1DvblSO
ascpt.onlinelibrary.wiley.com
Methadone has a high potential for risky drug–drug interactions that can lead to opioid overdose, yet evidence on the magnitude of this risk remains limited. Since methadone is transported via...
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Spotlighting an excellent paper by one of our first-year PhD students, Lin-Chieh Meng! Paternal metformin use and risk of congenital malformations in offspring in Norway and Taiwan: population based, cross national cohort study @LinChiehMeng
https://t.co/gkW46HR1mn
bmj.com
Objective To evaluate the association between paternal metformin use and risk of congenital malformations in offspring. Design Population based, cross national cohort study. Setting Norway and...
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Newly published in JAMA Neuro. and led by our own Emily Acton ⬇️ Direct-Acting Oral Anticoagulants and Antiseizure Medications for Atrial Fibrillation and Epilepsy and Risk of Thromboembolic Events @HennessySean @CE_Leonard @UPennDBEI
https://t.co/bs4FIOz7O4
jamanetwork.com
This cohort study assesses rates of thromboembolic events in adults with atrial fibrillation (AF) and epilepsy receiving direct-acting oral anticoagulants (OACs) and enzyme-inducing antiseizure...
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I hope to see you at the 2024 UPenn Summer Causal Institute, which will include a day on pharmacoepi / RWE
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New in Clinical Pharmacology & Therapeutics and led by @Alicechencheng : Comparative Risk of Injury with Concurrent Use of Opioids and Skeletal Muscle Relaxants @HennessySean @CE_Leonard @Miano81 @UPennDBEI
https://t.co/cdQ4hXWIg2
ascpt.onlinelibrary.wiley.com
Concurrent use of skeletal muscle relaxants (SMRs) and opioids has been linked to an increased risk of injury. However, it remains unclear whether the injury risks differ by specific SMR when...
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3) a supportive narrative of my day. I'm hoping that this puts me in a better mood and makes me a better conversationalist.
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2) people, offer another a faculty position (which she accepted!), nominate another for an award, and spend time writing a grant application for a project thta I'm really excited about. I'm going to try, when possible, to end my work day constructing...
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1) Last night when I got home from work, my wife asked me about my day. I mumbled something about having a lot of meetings. My mind instinctively went to *the grind*. Yet this morning when I looked at yesterday's calendar, I realize that I got to mentor three amazing...
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A note from my self-coaching journal 3): The to-do list is not a task master, but rather a safety net that allows one to focus on the task at hand knowing that we don't need to worry about keeping track of other tasks. Have faith in yourself!
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A note from my self-coaching journal 2): The long-term view recognizes that periods of disequilibrium in both directions are natural. One needs faith/confidence in one's self that the important stuff will get done. It always does.
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A note from my self-coaching journal 1): There is not always daily or even weekly equilibrium between what is added to and checked off of your to-do list. When more gets added than checked off, you have trouble seeing how it will all get done, and anxiety ensues.
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