Penn CREST
@Penn_CREST
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Center for Real World Effectiveness and Safety of Therapeutics @Penn Director:@HennessySean #pharmacovigilance #pharmepidemiology #drugsafety
Philadelphia, PA
Joined April 2015
We are excited to announce that the Center for Pharmacoepidemiology Research and Training (CPeRT) is transitioning to a new name - the Center for Real World Effectiveness and Safety of Therapeutics (CREST)!
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Great new paper in ACR Open Rheumatology, led by CREST investigator Josh Baker: Characterization of Second-Line Therapy After First JAK Inhibitor Use: Results From the CorEvitas Rheumatoid Arthritis Registry @UPennDBEI
https://t.co/RSdkgqI2RT
acrjournals.onlinelibrary.wiley.com
Objective We performed a real-world characterization of patients with rheumatoid arthritis (RA) who initiate a JAK inhibitor (JAKi) and switch to a subsequent therapy and examination of factors...
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New in JAMA Health Forum: Stimulant Overdose Prediction Model for Medicaid-Insured Persons @UPennDBEI @HennessySean
https://t.co/2DveuPtl5m
jamanetwork.com
This case-control study develops and validates a model to predict hospitalization or emergency department treatment for stimulant-involved overdose among the Medicaid-insured population.
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New in American Journal of Epidemiology: Effect of exogenous testosterone on cardiovascular, cerebrovascular, and thromboembolic adverse events: Results of three complementary research designs @TatThangVo1 @phuongpng @HennessySean @CE_Leonard
https://t.co/zDN6c2pt3L
academic.oup.com
Abstract. The cardiovascular risks of exogenous testosterone have been a subject of controversy. In this study, our objective was to examine the associatio
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New in Pharmacoepidemiology & Drug Safety ⬇️ Real-World Data and Real-World Evidence in Regulatory Decision Making: Report Summary From the Council for International Organizations of Medical Sciences (CIOMS) Working Group XIII @HennessySean @UPennDBEI
https://t.co/oDEHp4YCMi
onlinelibrary.wiley.com
Data from sources other than traditional randomized clinical trials are known as real-world data (RWD), and the evidence derived from the review and analysis of RWD is known as real-world evidence...
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Great new paper in Clinical Pharmacology & Therapeutics led by doctoral student Haedi Thelen: Characterizing Treatment Effect Heterogeneity Using Real-World Data https://t.co/RyWp9mNAHv
@HaediThelen @HennessySean
ascpt.onlinelibrary.wiley.com
Characterizing heterogeneity of treatment effects (HTE) is a fundamental goal of pharmacoepidemiology, addressing why medications work differently across patient populations. This paper reviews...
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Check out the latest from the CREST team in Pharmacoepidemiology & Drug Safety: Evaluation of Drug–Drug Interactions in Pharmacoepidemiologic Research @Alicechencheng @phuongpng @Miano81 @CE_Leonard @HennessySean
https://t.co/4XLVoHrJh2
onlinelibrary.wiley.com
Drug–drug interactions (DDIs) represent a significant concern for clinical care and public health, but the health consequences of many DDIs remain largely underexplored. This knowledge gap undersco...
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New publication in Journal of Geriatric Psychiatry and Neurology led by @phuongpng and featuring several CREST investigators ⬇️ Impact of Anticholinergic Burden and Clinical-Demographic Characteristics on Incident Dementia in Parkinson Disease https://t.co/Wib6f4BHZo
journals.sagepub.com
Purpose Anticholinergic medication use measured via the Anticholinergic Cognitive Burden (ACB) scale has been associated with an increased dementia incidence in...
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A great methods paper featuring several CREST investigators, newly published in the Electronic Journal of Statistics: Structural mean models for instrumented difference-in-differences @TatThangVo1 @HennessySean @UPennDBEI
https://t.co/u6pT1a8KuB
projecteuclid.org
In the standard difference-in-differences research design, the parallel trend assumption can be violated when the effect of some unmeasured confounders on the outcome trend is different between the...
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Newly published in Clinical Pharmacology and Therapeutics and featuring several CREST investigators: Risk of Hypoglycemia Associated with Concomitant Use of Insulin Secretagogues and ACE Inhibitors in Adults with Type 2 Diabetes: A Systematic Review https://t.co/XtUCZD6e93
ascpt.onlinelibrary.wiley.com
Insulin secretagogues and angiotensin-converting enzyme inhibitors (ACEIs) are commonly co-prescribed for patients with type 2 diabetes (T2D). Case reports suggesting that co-administration of...
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Ambient temperature & serious adverse health outcomes among users of different antidiabetes drugs ft. @CE_Leonard, Kacie Bogar, Colleen Brensinger, Warren Bilker, @Alicechencheng & @HennessySean @Penn_CREST @UPenn_CCEB @UPennDBEI @PennSysPharmATT
https://t.co/3WGhsKZp3n
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Interested in joining the CREST team? We're hiring! ⬇️ Manager Research Project B (Department of Biostatistics, Epidemiology and Informatics) https://t.co/4JVPcG9Kfs
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Check out the latest in JAMA Network Open, led by CREST investigator Mark Neuman ⬇️ Strategies to Limit Benzodiazepine Use in Anesthesia for Older Adults: A Randomized Clinical Trial @neumanmd
https://t.co/iF1oodDaGO
jamanetwork.com
This randomized clinical trial examines the efficacy of 3 clinician- and patient-facing strategies to reduce the use of benzodiazepines in anesthesia among older adults undergoing surgery.
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Spotlighting an excellent paper by one of our first-year PhD students, Lin-Chieh Meng! Paternal metformin use and risk of congenital malformations in offspring in Norway and Taiwan: population based, cross national cohort study @LinChiehMeng
https://t.co/gkW46HR1mn
bmj.com
Objective To evaluate the association between paternal metformin use and risk of congenital malformations in offspring. Design Population based, cross national cohort study. Setting Norway and...
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Newly published in Clinical Pharmacology & Therapeutics ⬇️ Risk of Opioid Overdose Associated with Concomitant Use of Methadone and Statins @Alicechencheng @Miano81 @CE_Leonard @HennessySean
https://t.co/vDO1DvblSO
ascpt.onlinelibrary.wiley.com
Methadone has a high potential for risky drug–drug interactions that can lead to opioid overdose, yet evidence on the magnitude of this risk remains limited. Since methadone is transported via...
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Check out the latest from the CREST team in Clinical Pharmacology & Therapeutics ⬇️ Concomitant Use of Oral Anticoagulants with Oral Dipeptidyl Peptidase-4 Inhibitors and Serious Bleeding Events @phuongpng @HennessySean @CE_Leonard @Miano81
https://t.co/sTjXyA6TU2
ascpt.onlinelibrary.wiley.com
In a prior screening study, saxagliptin, a dipeptidyl peptidase-4 inhibitor (DPP-4i), was found to have an increased rate of serious bleeding when used concomitantly with several oral anticoagulants...
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New in the American Journal of Epidemiology and led by our talented former post doc Hanxi (Molly) Zhang) ⬇️ Grace periods and exposure misclassification in self-controlled case-series studies of drug-drug interactions @CE_Leonard @HennessySean @Miano81
https://t.co/zwZwxzRYE0
academic.oup.com
Abstract. The self-controlled case-series (SCCS) research design is increasingly used in pharmacoepidemiologic studies of drug–drug interactions (DDIs), wi
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Newly published in JAMA Neuro. and led by our own Emily Acton ⬇️ Direct-Acting Oral Anticoagulants and Antiseizure Medications for Atrial Fibrillation and Epilepsy and Risk of Thromboembolic Events @HennessySean @CE_Leonard @UPennDBEI
https://t.co/bs4FIOz7O4
jamanetwork.com
This cohort study assesses rates of thromboembolic events in adults with atrial fibrillation (AF) and epilepsy receiving direct-acting oral anticoagulants (OACs) and enzyme-inducing antiseizure...
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Check out the latest in JAMA Internal Medicine featuring several CREST investigators ⬇️ Severe Acute Liver Injury After Hepatotoxic Medication Initiation in Real-World Data @HennessySean @UPennDBEI
https://t.co/O9hyFVkwHC
jamanetwork.com
This cohort study identifies the most potentially hepatotoxic medications based on clinical incidence rates of hospitalizations for severe acute liver injury (ALI) and examines how these rates...
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Newly published in Hepatology and led by CREST investigator Dr. Tess Bittermann: Real-world evidence for factors associated with maintenance treatment practices among U.S. adults with autoimmune hepatitis @UPennDBEI
https://t.co/hjIOSvlrWF
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