
HaitinLab
@HaitinLab
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Located at @TelAvivUni. We study the molecular basis of information transfer within ion channels and prenyltransferases.
Israel
Joined October 2018
Excited to share our new paper in @FEBSJournal! 🎉.We show how a #MYELOMA-linked GGPPS mutation tweaks hexamerization, substrate binding and product inhibition, revealing an unexpected layer of protein prenylation regulation .🔗 @peterslab1 @TAUMedFaculty.
febs.onlinelibrary.wiley.com
Geranylgeranyl diphosphate synthase (GGPPS) plays a key role in multiple myeloma biology. Using crystallography, mass spectrometry, and fluorescence spectroscopy, this study shows that a somatic...
🚨New preprint alert! Wonder how a cancer-associated mutation in GGPPS impacts hexameric stoichiometry, substrate affinity, and product inhibition? Our results shed light on a novel regulatory mechanism in protein prenylation #MultipleMyeloma.
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RT @Tel_Aviv_Uni: צוותי המחקר של פרופ׳ מורן רובינשטיין ופרופ׳ קרן אברהם, פיתחו מודל עכברי חדש המאפשר למצוא תרופות למחלה נדירה שרק 40 בני אד….
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W/ @moshegiladi @jvermaas @duncanboren .@TAUMedFaculty @SouraskyMedCtr @MichiganStat .We’re hiring PhD/MSc students! 🎓.
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How does a cytoplasmic enzyme make a membrane product? 🤔🧬. We found that a hydrophobic residue cluster helps the human cis-prenyltransferase feed its product into the ER membrane!. MD simulations + fluorescence = mechanistic insight 👇.🔗
onlinelibrary.wiley.com
Prenyl chains come in multiple sizes, fulfilling unique and essential functions across all domains of life. Prenyl chains are synthesized by prenyltransferase proteins. Despite their structural...
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RT @peterslab1: Whenever we get a bioRxiv alert, we'are always curious to see what it brings. This time, the timing couldn’t have been bett….
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💃🕺Happy to share a team effort to uncover the molecular "dance" behind human cis-prenyltransferase regulation!🔬🧬 @peterslab1 @AlbGiacomello #Biochemistry #StructuralBiology @TAUMedFaculty @of_sagol
biorxiv.org
Human cis-prenyltransferase (h cis -PT) synthesizes long-chain isoprenoids essential for N-linked protein glycosylation. This heteromeric complex comprises the catalytic subunit DHDDS and the...
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What a fantastic achievement! Congrats Moran and the team 🍾🎊🎉❤️.
Excited to share our paper! #GRIN2D-DEE 🐭model mirrors patient symptoms, from behavioral deficits and pathological brain activity to synaptic changes🔗 An incredible collaboration with a GRIN2D family, @KarenAvraham, researchers & clinicians.
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👀 Genetic background tuning and characterization of a #CHD2 mouse model! Congrats, Moran and the team 👏🎊💜💙💕#DEE @of_sagol @TAUMedFaculty @Tel_Aviv_Uni.
Excited to share our upgraded #CHD2 mouse model! 🐭🧠 It better mimics the disorder, revealing key symptoms like motor deficits, autistic features & altered brain function⚡️ .An amazing collaboration with @IgorUlitsky, supported by @curechd2. 🔗 Read more:
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RT @of_sagol: 💖Love, Science & the Brain💖.This #ValentinesDay, meet Profs. Moran Rubinstein & Yoni Haitin - a couple bonded by love & a pas….
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🚨New preprint alert! Wonder how a cancer-associated mutation in GGPPS impacts hexameric stoichiometry, substrate affinity, and product inhibition? Our results shed light on a novel regulatory mechanism in protein prenylation #MultipleMyeloma.
biorxiv.org
Protein prenylation regulates the cellular localization of small GTPases and is pivotal for multiple myeloma (MM) pathology. Geranylgeranyl diphosphate synthase (GGPPS), synthesizing a prenylation...
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Congrats @Eyal_Roz and Shiko!.
1/ How do animals integrate different forms of learning? Our @Eyal_Roz new study in @ScienceAdvances shows that active mechanisms prevent the co-formation of competing memories. Here’s what we found! 🧵👇.Art by @Ella_Maru
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RT @peterslab1: Long overlooked but significant!.This is the post-Cys specificity in post-proline cleaving enzymes like AnPEP or neprosin.….
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Amazing!!! 👏🤩 #ProudMentor.
Huge thanks to the #EMBLHamburg scientists, organizers, and of course, all the bright and promising participants for the joy and inspiration during the 8-day Membrane Protein Expression, Purification, and Characterisation 3 (mPEPC3) course. #EMBOPEPC See you all again soon!
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RT @Bargamish: Huge thanks to the #EMBLHamburg scientists, organizers, and of course, all the bright and promising participants for the joy….
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🚨📣Excited to share we found Magnesium’s 🏠| By combining computational and experimental approaches we identified the magnesium binding site in NCX, exposing the structural basis for its physiological modulatory mechanism. Led by @Bargamish @TAUMedFaculty
onlinelibrary.wiley.com
Sodium–calcium exchanger (NCX) proteins are ubiquitously expressed and play a pivotal role in cellular calcium homeostasis by mediating uphill calcium efflux across the cell membrane. Intracellular...
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