
Philip Gunkel
@GunkelPhilip
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@philipgunkel.bsky.social Postdoc @mpi_nat; Research focus: the nuclear pore complex and in particular the nuclear basket - composition and function.
Göttingen
Joined July 2020
See you on the other (hopefully brighter) side: @philipgunkel.bsky.social.
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RT @embojournal: A nanobody toolkit for tracking or blocking nuclear pore complex (NPC) biogenesis identifies a checkpoint linking assembly….
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RT @KarstenWeisLab: Congratulations to Janka Zsok and Elisa Dultz for their paper on the #nuclearpore basket in collaboration with @LucienW….
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RT @IJMonod: ✍️The Doye Lab's (@DoyeValerie) new article "Y-complex nucleoporins independently contribute to nuclear pore assembly and gene….
journals.biologists.com
Highlighted Article: The Y-complex nucleoporins Nup133 and Seh1 have roles in gene regulation upon neuroectodermal differentiation, and this process can be uncoupled from nuclear pore basket integr...
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9/9 Finally, the ZC3HC1 structure predictions by AlphaFold2 illustrate an evolutionarily conserved NuBaID construction and enabled the redefinition of BLD boundaries. These predictions are consistent with the recent crystal structure of Pml39p by Hashimoto et al. @PalancadeLab.
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7/9 It was already known that Pml39p is a Mlp-interacting protein (Palancade et al. 2005 @DoyeValerie). We have now shown that Pml39p is required for positioning Mlp1p subpopulations at the NB, in line with a recent report by Bensidoun et al. @BensPierre4 @rnp_biology @zenklusd
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1/9 Finally, in press @MBoCjournal: our description of the evolutionary conserved TPR-/Mlp-binding domain of ZC3HC1/Pml39p.
molbiolcell.org
The proteins ZC3HC1 and TPR are structural components of the nuclear basket (NB), a fibrillar structure attached to the nucleoplasmic side of the nuclear pore complex (NPC). ZC3HC1 initially binds to...
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RT @pleinerlab: Purifying eukaryotic proteins & their complexes at the scale & purity needed for structural, functional or mass spec charac….
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It's that time of year again when you do flow cytometry and your brain goes like this:. ♪ Single cells, single cells,.… Oh! what fun it is to sort.single cells all day. ♪. @ghoshnotgosh #FACS #jinglebells #singlecells
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RT @TinoPleiner: Cellular compartmentation requires stringent sorting of thousands of proteins to their correct destination. Our new pre-pr….
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RT @StefanHellLabs: Interested in the raw data of our paper “MINSTED nanoscopy enters the Ångström localization range”? ..
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RT @Stefan_W_Hell: #STED at Å precision! See New article by Weber, von der Emde et al. Fantastic applications ahead….
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