Check out our latest findings on Type 1 Diabetes and how specific microRNAs could help our understanding and future treatment approaches. #Diabetes #T1DM #MicroRNAs @Innodiagroup @unisiena.

RT @unisiena: ‼️Individuati dai ricercatori dell'#Università di #Siena nuovi #biomarcatori per il trattamento personalizzato del #diabeteme….

RT @GuidoStr3: Check out our latest findings on Type 1 Diabetes and how specific microRNAs could help our understanding and future treatmen….

7/ Future studies will focus on the exact mechanisms through which these miRNAs influence T1DM progression and how they can be leveraged in clinical practice. For those interested in the details, check out our full paper published in @CellRepMed

6/ This research also underscores the importance of non-coding RNAs in disease management, offering new avenues for therapeutic development and better understanding of T1DM pathogenesis. 🌟.

5/ Why is this important? Identifying these subgroups can help tailor immunotherapies to individual patients, potentially improving outcomes and reducing the burden of lifelong insulin therapy.

4/ The study involved 256 individuals with recent-onset T1DM from @Innodiagroup, using advanced sequencing technologies to ensure robust and reliable results. Consistency in findings across two cohorts reinforces the potential of these miRNAs as biomarkers.

3/ Patients were categorized into Cluster A and Cluster B. Interestingly, Cluster B showed better glycemic control and unique immune profiles. Could this mean a step towards more targeted diabetes therapies? 🤔.

2/ Specifically, microRNAs from the 14q32 chromosomal locus play a key role. These miRNAs, especially miR-409-3p, miR-382-5p, and miR-127-3p, were pivotal in differentiating the two subgroups. #Genomics #Diabetes.

1/ In our recent study, we identified two distinct subgroups of T1DM patients based on their circulating microRNA profiles. This could pave the way for personalized treatment strategies. #precisionmedicine.

RT @genome_gov: RNA is…complicated. If it’s not confusing enough that there are many types of RNA, some RNA molecules also fold into differ….

IL-22RA1 receptor has a crucial role in the pancreas. Blocking IL-22RA1 impairs insulin quality, increasing stress in human islets. Mice lacking IL-22RA1 in beta-cells show decreased insulin secretion and increased inflammation.#DiabetesResearch #IL22RA1.

Happy to have contributed in this groundbreaking story led by @sumaira_hasnain,showcasing promising IL-22-targeted treatments for diabetes and liver steatosis. Check out the full details here Don't miss the insightful tweetorial by @sumaira_hasnain below!.

Thrilled to be an invited speaker at the #IDS2024 Rising Stars symposium! Join me for my lecture, "From Whispers to Shouts: The Impact of Circulating microRNAs on T1D Progression and Stratification." Can't wait to share insights with fellow experts! #Immunology #T1D @unisiena.

RT @ImmDiabSoc: 🚨Our latest #program is now ONLINE! What’s your favorite #IDS2024 session?

RT @eportacangen: Want to know how VISIUM, CytAssist, CosMx, Xenium and CytAssist protein compare with each other in human tumors?. Then th….

Autoimmune diseases are the by-product of past.evolutionary selection against environmental pathogens. It was a trade off between protection against infections (at that time) and risk of autoimmunity (present day)

RT @ImmDiabSoc: Happy #DayofImmunology! 📢 Fascinated by the #immunology of #type1diabetes? Join us at #IDS2024 congress in Bruges 🇧🇪 Togeth….

RT @GuillaumeWatt: Yeah this is stunning, Ashley Gruber you've done it again 👏

RT @AlbertVilella: I have now added the $OMIC Singular Genomics G4X Spatial offering in the #SingleCell #SpatialBiology table of commercial….