Introducing our next DR residents #futureradres #Match2024

Join @shadowdoc (and Rex 🐘) in exploring the basics of #ImagingInformatics systems & web-based protocols and diving into the life cycle of a radiology exam. #NIIC https://t.co/QMD0SoFvfK @RSNA @dpatweet @theAPDR @apcprods

Thanks again, @AliTejaniMD ! A perfect primer to get us ready for more imaging informatics and AI at NIIC-RAD next week @SIIM_Tweets

Fantastic seminar today during the @IURadiology resident conference from @AliTejaniMD on LLMs in radiology. So much impressive progress in this area but still many barriers (bias, security, hallucinations, interpretability etc.) before these models reach mainstream use in rads

#MedStudentTwitter join for this exciting panel discussion tomorrow night at 7pm EST led by our very own @IUSMRadSIG. You don’t want to miss this chance to learn about a career in radiology from some of our leading experts! Register: https://t.co/BtrSU7P4Ox

We are excited to announce our first event of the 2023-24 AY! Please join us for a panel discussion with some of our incredible faculty. Details below. Register to attend at https://t.co/0MZwdwQwdU

Check out our new study looking at the long-term effects of prenatal opioid exposure on the brain using the @NeurosciStark 9.4T preclinical MRI!

@IndianaUniv scientists @BradyAtwood @GreccoGregory & colleagues explore the impact of #methadone treatment for #OUD on sensorimotor development in the offspring of mice with prenatal exposure. See Advances in Drug and Alcohol Research for more! 🔎🐁 https://t.co/ItpIgmCFjy

Multi-Omics, electrophysiology, endocannabinoids, opioids, plasticity, and sex-effects. All the necessary ingredients for an awesome story!

New work from us in the Atwood lab @BradyAtwood @braulioblas on our prenatal opioid exposure model. This time involving an awesome collab with IUSMs Center for Proteome Analysis @fireinlab @MosleyLab check it out in eNeuro @SfNtweets

Maybe the effects on the reward are not specific to any one drug? Stay tuned for another paper looking at PME effects on reward-related brain regions. Thanks @NIAAAnews for funding my F30 to do this work plus support from @NeurosciStark @IUSMPharmTox @IUMedSchool (8/8)

So PME influences alcohol drinking enough that we can reliably predict exposure from drinking data alone. Overall, this suggests prenatal opioid exposure may not only increase opioid addiction risk, but maybe alcohol as well (7/8)

@david__haggerty took our drinking data (microstructure via lickometers and volume consumed) and built a ML model to see if we could predict prenatal exposure from drinking patterns. Even with a limited sample size, we could predict PME at 70% accuracy. (6/8)

PME-females are hyperactive in response to alcohol treatment (but this doesn’t seem to be sensitization). PME-males show altered conditioned preference, but drink more alcohol and show some aversion resistant drinking (~compulsion~, maybe) (5/8)

Alcohol is much more widely available and used relative to opioids so if we’re worried about increased addiction in this population, we should look at alcohol. Using our prenatal methadone exposure (PME) model, we found sex-dependent effects on alcohol reward behaviors (4/8)

It turns out, prenatal opioid exposure = increased opioid consumption, preference, sensitization etc later in life (in rodents). But is opioid addiction really the biggest risk facing kiddos with prenatal opioid exposure? I don’t think so.. (3/8)

I don’t think you have to be an addiction neuroscientist to wonder if prenatal opioid exposure affects reward behavior later in life. I had this same thought when i started my PhD. So i went to the preclinical literature. (2/8)

Check out some exciting work from @david__haggerty and I in the Atwood lab @BradyAtwood. I shared some of this data at my PhD defense but glad to see the whole story out now. Quick thread. https://t.co/lcFFqPTMNy (1/8)

We still have lots of work to do with this project and others using our mouse model. Stay tuned for more soon. Thanks to @GenomicsIU @yunlongliu for making this project possible and @NeurosciStark @IUMedSchool for supporting us. (5/5)

Crazy idea: we know the microbiome can shape behavior through various mechanisms (bacterial metabolites, inflammation), so maybe the behavioral differences we see ( https://t.co/EQ1nIKJdQI) in opioid exposed offspring result from changes in gut microbes?? (4/5)