Patrick Glassman
@GlassmanLab
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Assistant Professor of Pharmaceutical Sciences at Temple University
Philadelphia, Pennsylvania
Joined October 2022
New publication in collaboration with @PennMedicine, @PennEngineers , and @AcuitasTx in @PNASNews ! Systemic delivery of biotherapeutic RNA to the myocardium transiently modulates cardiac contractility in vivo | PNAS
pnas.org
Lipid nanoparticles (LNP) represent a versatile platform for improving delivery of therapeutic nucleic acids. Yet, delivery to the myocardium remai...
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Excited to be a part of this really talented team and contribute our expertise to characterize PK/PD of live biotherapeutics!.
We're incredibly grateful to the #NIH for supporting our research with a $3 million 4-year R01 grant to develop targeted probiotic yeast therapies for inflammatory bowel diseases. @DPMP_UNC @UNCPharmacy
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We are now accepting applications for our online Graduate Certificate in PK and Mechanistic Modeling, which launches in Fall 2025! Please reach out with any questions! .
www-drupal.temple.edu
Receive the training necessary to enhance your career in pharmacokinetics with this graduate certificate.
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In addition, our PY2 student Manali Patel was selected as the top PharmD student abstract and gave an oral presentation on her work on half-life extended anti-thrombotics!
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Last Friday was @TU_SP Research Recognition Day and our group had four poster presentations by PharmD and PhD students!
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Please reach out if you are interested in submitting a primary research article or minireview to this issue - especially if you have a trainee that would be interested in the Challenge Award! @JPET_Journal @ASPET.
ASPET’s JPET and @PhRMAFoundation are partnering on a Challenge Award competition—a prize of $5,000—to the first author of up to five winning papers! Submit your papers on the #pharmacology of next generation therapeutics by July 1, 2025. 🔗Learn more:
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RT @JPET_Journal: ASPET’s JPET and @PhRMAFoundation are partnering on a Challenge Award competition—a prize of $5,000—to the first author o….
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I'm happy to share our latest publication in @BioconjChem describing the use of RBCs as carriers to prolong the circulation time of Factor IX!
pubs.acs.org
Red blood cells (RBCs) serve as natural transporters and can be modified to enhance the pharmacokinetics and pharmacodynamics of a protein cargo. Affinity targeting of Factor IX (FIX) to the RBC...
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RT @JPET_Journal: ASPET’s JPET and @PhRMAFoundation are partnering on a Challenge Award competition—a prize of $5,000—to the first author o….
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Happy to share information about a special issue of @JPET_Journal that I am co-editing with @JulieNguyenLab entitled Pharmacology of Next Generation Therapeutics. We've partnered with @PhRMAfoundation, who is sponsoring a Trainee Challenge Award!.
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RT @ASPET: ASPET’s Editorial Fellowship Program is accepting applications for its 2025 class. Fellows will learn important elements of the….
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RT @JPET_Journal: ASPET’s Editorial Fellowship Program is accepting applications for its 2025 class. Fellows will learn important elements….
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RT @gross_lab: Register now for the upcoming Focus on Pharmacology seminar:. @K_S_Abdelrahman @camielnik @JPET_Jour….
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Thrilled to have participated in this collaborative effort with @jakebrenner lab, which investigated the role of liposomal encapsulation and vascular targeting on the in vivo pharmacology of fingolimod. @JCRnEDITORS #drugdelivery.
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Off to Holderness for the Drug Metabolism GRS/GRC. Excited to participate in the GRS Mentoring Panel and share our research on predictive approaches for half-life extension of peptides and proteins (M/T poster session)!.
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New paper published from the lab focusing on the development of a regression-based approach to predict the impact of half-life extension on PK parameters! Major predictors were identified to be related to the parent molecule's PK and molecular weight.
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Heading to Alexandria tomorrow for #ASPET2024. I'll be presenting our PK/PD modeling of nanoparticles at the following times: . Saturday, 5/18: 11:35 AM-12:15 PM, Division for TCP Young Investigator Awards Platform.Saturday, 5/18: 5-7 PM, Poster #435. #pharmacology
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Really enjoyed this Perspective piece in @ScienceMagazine highlighting the importance of understanding pharmacokinetics in furthering development of nanomedicine!.
Colloidal nanoparticles are being developed for disease treatment and diagnosis. A new #SciencePerspective looks at what is needed to improve nanoparticle design and tailor them to their intended applications.
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Really happy to see that @MolTherapy has published a Commentary on our recent article on VCAM-targeted nanoparticles for the treatment of stroke! #drugdelivery.
VCAM-targeting lipid platform brings new hope to the treatment of ischemic stroke #genetherapy #celltherapy.
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Another paper! In collaboration with @WeissmanLab, we developed a PBPK/PD model for mRNA-LNP delivery. This is the first step towards developing predictive, translational models for nanomedicine! @MolTherapy @TU_SP @PennMedicine
cell.com
Glassman and colleagues have evaluated how the spatiotemporal disconnect between LNP delivery and transgene expression poses challenges in prediction of PK/PD relationships. A physiologically based...
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