🍃 Giant cells in leaves! We show that the pathway controlling giant cell formation in sepals also controls cell size in leaves, and that a cell-autonomous and stochastic specification leads to a non-random cellular pattern! See https://t.co/fb5pD3jpX7 1/6

Graduate students are not machines. Behaving like one during your programme will leave you frustrated and unfulfilled https://t.co/NZPooK7kii

Taking the last train to leave from here. Find me on https://t.co/Z6Qe8gv6rR. #quitterX

The hardest part of a PhD isn’t the work—it’s its psychological challenges. Advice on productivity is everywhere, but PhD students are human beings first. I wrote 7 (subjective) rules to navigate it. 🫂🌱 #academia #phdchat

This happened. The title feels insignificant compared to the experience of the journey, and the diversity of great people I met along the way. Thanks to all of them. Special thanks to my advisor @PauFormosa. @mpipz_cologne

The newest discovery in our robustness research thanks to Dr. Shuyao Kong @sykong15, @Mingyuan2328, @RichardSmithLab, David Pan, and Brendan Lane. Tradeoff between speed and robustness in primordium initiation mediated by auxin-CUC1 interaction https://t.co/GwHOwL93Mp

Thanks Clark, Wang, @RoederLab for the great collaboration, @PauFormosa , all co-authors, and @mpipz_cologne. See the full story: https://t.co/fb5pD3jpX7. 6/6

But can the stochastic mechanism proposed for giant cell specification lead to clustering without cell-cell communication? Yes, in a growing tissue. Our simulations show that the giant cell pattern becomes non-random as the surrounding cells divide. 5/6

By comparing our tissues with computationally generated randomized tissues (using the method from https://t.co/fFXAeuz1Cb), we found that giant cells are more clustered than expected by chance! 4/6

We classified cell types and defined giant cells based on a cell size threshold. Because giant cells are scattered alongside smaller cells, we asked: Are giant cells randomly organized? 3/6

Leaf epidermal cells have a wide range of sizes and ploidies. By analyzing cell sizes in mutants, we show that the pathway promoting giant cell formation in the sepal similarly controls cell size in the leaf epidermis. 2/6

Is giant cell patterning random in sepals and leaves? Check out our new work combining quantitative microscopy, computational methods and modeling, a great collaboration with Clark @Weissbart Wang @Roederl and co-authors! @mpipz_cologne @ceplas_1 @Cornell https://t.co/q7DAxOkZ1j

For at least the last 15 years I have wanted to know whether giant cells are randomly spaced in the sepal. We finally have an answer! They start random and become nonrandom as the surrounding cells divide. Geat collaboration @PauFormosa @GauthierWeissb1 https://t.co/24Un6pDCkt

If you thought you didn't have to pay attention to giant cells because they are only in sepals, think again. Giant cells are found in Arabidopsis leaves too, and their development is controlled by the same genes. @PauFormosa @GauthierWeissb1 https://t.co/24Un6pDCkt

Noise, redundancy, slowness, heterogeneity, incoherence, are some properties that make life robust and adaptable. Can these 'sub-optimal' values inspire us to build a more resilient society? His previous book (left) explores this. Hoping for an English translation!

I got the last book (right) by Olivier Hamant! In contrast to our societies, which strive for optimality and performance, he explains that life is not as optimal as we think. However it's better: it's resilient (robust and adaptable)!

Giant cells specification relies on very long-chain fatty acids, as well as its fate maintenance. Thanks @RoederLab for sharing this journey with us, congrats @Vijaya_Battula @NickRussell31 @SaketBagde @jcfromme @msu_skirycz @swalsmugs and co-authors!

excited to finally see this published in @Dev_Cell! this piece was a true *𝘵𝘰𝘶𝘳 𝘥𝘦 𝘧𝘰𝘳𝘤𝘦* and an amazing collaborative effort with @RoederLab about common themes in plant and animal morphogenesis🌱🪰🔖 https://t.co/w5mz7yqqZu

Our approach to infer forces from 3D fluorescence microscopy is published in Nature Methods ! https://t.co/L5qNsO5KhT Congrats to all authors @SachaIchbiah @RDumollard @Alex_Mc_Dougall @HerveTurlier Simply type pip install foambryo to try And stay tuned... @CirbCdf @CNRSbiologie

Short-term contracts affect research and diversity efforts in German Academia. Our perspective article is out in @FrontPsychol. Thanks to @j_d_davidson @hlschaare @FHillemann @TryNathan @SajjadSafaei0 for the work on this article! #WissZeitVG #ichbinhanna https://t.co/kzGqdLMSh7