📢Paper alert: Matrix degradation enhances stress relaxation, regulating cell adhesion and spreading | PNAS. Often our studies focus on how the mechanics of the environment impact cell behavior...but it's a two-way street...cells can also effect changes on their environment.

The N.I.H. has terminated hundreds of diversity grants awarded to young researchers, many of whom come from the very places that supported Trump. https://t.co/4r684hWmPU

Our new paper on A Clearer Look at Diabetic Kidney Disease

This has implications for regenerative medicine, where degradable scaffolds are used to promote cell infiltration and tissue repair.

Since biomaterial properties are typically assessed post-manufacture without accounting for cellular modification, adjusting for degradation effects will be crucial for engineering biomaterials that sustain desired environmental conditions and regulate cell behavior effectively.

It also shows that local degradation by cells can result in materials that are biophysically distinct from their initial characterizations.

This study shows that hydrogel degradability can be used as a design variable to engineer stress relaxation and cellular adhesion, with far-reaching implications for the development of future biomaterials.

Cells embedded inside these synthetic hydrogels and using their own MMPs showed a similar response, spreading less in the cell-degradable (CD) gels than the non-degradable (ND) gels.

Cells sensed these MMP-induced changes in stress relaxation, spreading less and forming fewer and smaller focal adhesions.

To verify that cells were actually sensing the changes in stress relaxation caused by MMPs, we engineered a synthetic hydrogel with MMP-degradable peptides. When treated with increasing amounts of MMPs, its stiffness doesn't change, but it relaxes faster, like the natural ECM.

Cells sensed the MMP treated ECM, spreading less that they normally do on the untreated ECM.

and the mechanics of the ECM. Increasing MMPs didn't change the stiffness of the ECM, but did increase its stress relaxing behavior.

In this study, the incredibly talented @badz_nithin asked whether the small cuts in the ECM cells make with their MMPs change the mechanics of the environment in a way that cells can feel...a feedback loop! We found that even small amounts of MMPs change the architecture...

Cells do this in multiple ways, including by using enzymes called matrix metalloproteinases (MMPs) to trim away at their environment, the extracellular matrix (ECM).

Thank you @UCSD for building awareness and facilitating conversations about how federal funding fuels discoveries that cure diseases and solves global challenges. Check out the video about how federal grants work and what���s at risk if they’re cut! https://t.co/J8awERAYds

The House just passed a Continuing Resolution (CR) to fund the government through September. Here’s what that means for science funding and what happens next.

Please Support Strong FY25 Funding for Biomedical Research by March 14.@senalexpadilla

Did you know - the medicine that President Trump takes each day to lower his risk of having a heart attack is a direct result of NIH funding? Let me explain -

For NIH reform: Dig into (and augment) the data published by A.Mirin (J Women's Health 2021) and ask "does it make sense" to any condition that is an outlier in the plot of $$NIH funds/year vs DALY. (Nature later reported on this). Adjust up/down if the answer is "No".

Penn to reduce graduate admissions, rescind acceptances amid federal research funding cuts