The Ozaki (A01) group, in collaboration with Prof. Teigo Asai group @Asai__lab, demonstrated that the ketosynthase domain of a highly-reducing polyketide synthase catalyzed β-lactone formation in the biosynthesis of hymeglusin. @J_A_C_S

The Ushimaru group (A01), in collaboration with Prof. Hung-wen Liu, has uncovered a sulfur incorporation mechanism generating the thionucleoside antibiotic albomycin. @NatureCatalysis.

Thank you all for making our conference in Fukui a great success! The talks and discussions were fantastic. See you in February at our next symposium at RIKEN, Tokyo!

The Oguri group (A03) has established a synthetic strategy that enables scaffold-level redesign of ecteinascidins, unlocking access to potent anticancer macrocycles. available at: press release: @Chem_CP.

The Terada group (A02), in collaboration with Dr. Leow (A02), has developed ColabReaction — a cloud-based tool for accelerated transition state searches using Direct MaxFlux (DMF) and the ML potential (UMA).available at: preprint:

The Katsuyama group (A03) discovered the biosynthetic gene cluster for thrazarine, a diazo group-containing amino acid, in actinobacteria and the hydrazine synthase ThzN catalyzing formation of a key intermediate from L-threonine and N6-hydroxylysine.

RT @ykguitar1002000: Chemoenzymatic synthesis and in vitro selection of de novo thiazole‐containing macrocyclic peptides - Saito - Chemistr….

The Goto group (A03), in collaboration with Prof. Onaka (A03), developed an in vitro selection platform for macrocyclic peptide ligands bearing backbone thiazoles via posttranslational chemoenzymatic conversion. @ChemEurJ.

プログラム（概要）はこちらです

第六回公開シンポ���ウムは2025年7月18-19日に福井県繊協ビル 10 階ホール（福井駅徒歩10分）で開催いたします！参加登録を受け付け中ですので、奮ってご参加ください！

RT @J_A_C_S: Arginine-N,N′-bisprenyltransferases: Switchable Catalysis in Consecutive Guanidine-N-prenylation | Journal of the American Che….

The Wakimoto group (A03), in collaboration with Prof. Ikuro Abe, has determined the crystal structure of a new, highly versatile Arg-N,N′-bisprenyltransferase DciF, unveiling the structural basis of its unique bisprenylation reaction. @J_A_C_S

The Terada group (A02) developed a novel terpene analysis approach that is high-speed, high-accuracy, and high-resolution by combining the Direct MaxFlux method with machine learning (ML) potentials. DOI:10.26434/chemrxiv-2025-md8k6.

RT @ykguitar1002000: Expanding the Diversity of the Terpene Skeleton and Structure through Identification of Noncanonical Class IE and IF T….

The Sato group (A01) demonstrated that the protein-structural-model-based genome mining can expand the diversity of terpene skeletons and structures.| Organic Letters.

The Katsuyama (A03) and Terada (A02) groups revealed the mechanism of ATP-dependent diazotase by combining structural biology, biochemistry and computational analysis. @angew_chem #Enzyme #biosynthesis.

RT @J_A_C_S: NHC-Mediated Radical Acylation Catalyzed by Thiamine- and Flavin-Dependent Enzymes | Journal of the American Chemical Society….

The Kato group (A03) developed a novel biocatalytic system using T. bispora acetolactate synthase. The engineered variants showed high activity for abiotic radical acylation of α-bromo carbonyls and N-acyloxyphthalimides. @J_A_C_S.

The Kuzuyama (A01) & Terada (A02) groups revealed the significance of the cryptic amino group of the hydroquinone intermediate common to the biosynthesis of tetrahydroxynaphthalene-derived meroterpenoids such as furaquinocin and naphterpin #MyFirstChemSci.

The Kuzuyama group (A01), in collaboration with Prof. Jeroen S. Dickschat, has identified a pair of cyanobacterial terpene synthases to produce a rare 6,6,7-tricyclic diterpene alcohol, deepening our mechanistic understanding of terpene cyclases.@J_A_C_S .