Fariñas Lab
@FarinasLab
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Molecular Neurobiology unit at @_BIOTECMED @UV_EG. Studying Neural Stem Cells biology and adult neurogenesis. Tweets by lab members. https://t.co/vXZq7xD7TP
València, Spain
Joined October 2020
RT @CienciaGob: 🏆 Isabel Fariñas Gómez, Premio Nacional de Investigación Santiago Ramón y Cajal en Biología. Por su destacada trayectoria….
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RT @CienciaGob: 👩🔬👨🔬 Esta semana, hemos celebrado la entrega de los Premios Nacionales de Investigación 2024, el reconocimiento más impor….
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RT @rtve: Descubren un nuevo mecanismo que participa en la propagación del Parkinson en el cerebro.
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RT @EFE_CValenciana: 🟢Descubren un nuevo mecanismo que participa en la propagación del Parkinson en el cerebro
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RT @EPCValenciana: Descubren un nuevo mecanismo que participa en la propagación del párkinson en el cerebro @UV_EG.
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RT @MolNeuro: 'Age-dependent progression from clearance to vulnerability in the early response of periventricular #microglia to α-#synuclei….
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6/ Huge thanks to our amazing collaborators @ibis_sevilla @VHIR_ @IIS_IdISSC @UCV_svm @Neuro_Bordeaux . Read the full paper here: 🔗
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5/ Could boosting microglial function be a therapeutic strategy? Enhancing αSyn clearance while preventing age-related dysfunction might help slow disease progression. More research is needed! 🔬.
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4/ Key takeaways:.Young microglia act as a first line of defense against toxic αSyn. With aging, microglia shift from clearing αSyn to facilitating its spread, potentially accelerating PD progression.
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3/ Most strikingly, microglia from older mice exposed to Lewy body fractions from human PD brains not only accumulated αSyn but also seeded new aggregates in nearby neurons. This suggests that aged microglia might promote disease propagation.
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2/ Aging changes everything. In older mice, microglia fail to degrade αSyn efficiently, leading to its accumulation and spread. We also observed this accumulation in microglia from human PD brains.
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1/ Microglia act as the brain’s immune cells, clearing harmful materials. We found that periventricular microglia monitor the cerebrospinal fluid (CSF) and actively phagocytize toxic αSyn species—at least when they are young. 🧠💪.
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📢New paper from our lab in @MolNeuro ! We investigated how microglia respond to toxic α-synuclein (αSyn) in Parkinson’s disease (PD) and how aging changes this process. Here are the key findings 🧵👇
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RT @FundacionLilly: @IIBmCSICUAM Para @IsabelFarinas, neurobióloga en la @uv_eg, "la investigación científica es una labor que siempre te m….
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RT @Hora25: Isabel Fariñas, neurobióloga: "El cáncer es terrible, pero sabemos cómo se produce. En las enfermedades neurodegenerativas, aún….
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RT @CienciaGob: 🏆 Premio Nacional de Investigación 2024 en la modalidad Santiago Ramón y Cajal, en Biología. A Isabel Fariñas, por su dest….
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Celebrating with @IsabelFarinas on her recent win of the Santiago Ramón y Cajal National Research Prize 2024. We’re incredibly proud of you!
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RT @SEBiolDev: Desde la @SEBiolDev felicitamos a Isabel Fariñas @FarinasLab @UV_EG por el Premio Nacional de Investigación Santiago Ramón y….
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